Induction of G-quadruplex DNA structure by Zn(II) 5,10,15,20-tetrakis(N-methyl-4-pyridyl)porphyrin

Surface complex of ZnTMPyP4 metalloporphyrin with double-stranded Poly(A)-Poly(U)

“…It is believed that the insertion of the central ion in the porphyrin can help improve the selectivity of such reactions with biopolymers. This hypothesis was confirmed somewhat by the information that [MeTMPyP4] compounds were successfully used to target specific DNA motifs [14][15][16]. These findings are consistent with tentative conclusions derived from the footprinting studies demonstrating that groove-binding metalloporphyrins species protect AT-rich areas of DNA, e.g., when Me = Mn, Fe, Co and Zn [17].…”

Microwave-assisted synthesis of phenanthroimidazole derivatives as stabilizer of c-myc G-quadruplex DNA

“…In general, small molecules exhibit characteristic absorption in electronic spectra which will undergo hypochromism and red shift in the presence of biology molecules and the degree of change depend on the binding affinity. 20 As shown in Figure 3A, the electronic spectra of 5 in Tris-HCl buffer(pH = 7.2) solution exhibit the characteristic IL (intraligand charge transfer) absorption in the range of 250-300 nm with the maximum at 274 nm. When c-myc G4 DNA was added into the solutions, obvious hypochromism and red shift was observed.…”

Porphyrins in complex with DNA: Modes of interaction and oxidation reactions

“…Their affinity is similar or even better than that of non-metalated porphyrin due to a lower electron density on the metalated porphyrin framework allowing higher stacking interaction with G-quartet. In contrast, octahedral complexes with two axial ligands on the metal that would pose a block to stacking interactions, exhibit lower affinity [71,103,112,[121][122][123][124][125]. Logically, due to their strong affinity for DNA duplex, none of these metalated TMPyP4 porphyrins are selective for G4 with respect to double-stranded DNA.…”