Induction of fetal abnormalities and genotoxicity by molybdenum nanoparticles in pregnant female mice and fetuses

Mohamed, Hanan R. H.; El-Atawy, Radwa H.; Ghoneim, Ahmed M.; El-Ghor, Akmal A.

doi:10.1007/s11356-020-08137-0

Cited by 17 publications

(8 citation statements)

References 27 publications

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“…In fetal liver, the opposite was observed, where concentrations of Mo were greater for LG than MG fetuses. Experiments in swine [ 25 ], rats [ 26 ], mice [ 27 ], and humans [ 28 ] have demonstrated that Mo has the ability to cross the placental barrier. However, it is not clear to what extent the maternal diet influences concentrations of Mo in fetal tissues.…”

Section: Discussionmentioning

confidence: 99%

Vitamin and Mineral Supplementation and Rate of Gain in Beef Heifers II: Effects on Concentration of Trace Minerals in Maternal Liver and Fetal Liver, Muscle, Allantoic, and Amniotic Fluids at Day 83 of Gestation

McCarthy

Menezes

Kassetas

et al. 2022

Animals

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We evaluated the effects of vitamin and mineral supplementation (from pre-breeding to day 83 of gestation) and two rates of gain (from breeding to day 83 of gestation) on trace mineral concentrations in maternal and fetal liver, fetal muscle, and allantoic (ALF) and amniotic (AMF) fluids. Crossbred Angus heifers (n = 35; BW = 359.5 ± 7.1 kg) were randomly assigned to one of two vitamin and mineral supplementation treatments (VMSUP; supplemented (VTM) vs. unsupplemented (NoVTM)). The VMSUP factor was initiated 71 to 148 d before artificial insemination (AI), allowing time for the mineral status of heifers to be altered in advance of breeding. The VTM supplement (113 g·heifer−1·d−1) provided macro and trace minerals and vitamins A, D, and E to meet 110% of the requirements specified by the NASEM, and the NoVTM supplement was a pelleted product fed at a 0.45 kg·heifer−1·day−1 with no added vitamin and mineral supplement. At AI, heifers were assigned to one of two rates of gain treatments (GAIN; low gain (LG) 0.28 kg/d or moderate gain (MG) 0.79 kg/d) within their respective VMSUP groups. On d 83 of gestation fetal liver, fetal muscle, ALF, and AMF were collected. Liver biopsies were performed prior to VMSUP factor initiation, at the time of AI, and at the time of ovariohysterectomy. Samples were analyzed for concentrations of Se, Cu, Zn, Mo, Mn, and Co. A VMSUP × GAIN × day interaction was present for Se and Cu (p < 0.01 and p = 0.02, respectively), with concentrations for heifers receiving VTM being greater at AI and tissue collection compared with heifers not receiving VTM (p < 0.01). A VMSUP × day interaction (p = 0.01) was present for Co, with greater (p < 0.01) concentrations for VTM than NoVTM at the time of breeding. VTM-MG heifers had greater concentrations of Mn than all other treatments (VMSUP × GAIN, p < 0.01). Mo was greater (p = 0.04) for MG than LG, while Zn concentrations decreased throughout the experiment (p < 0.01). Concentrations of Se (p < 0.01), Cu (p = 0.01), Mn (p = 0.04), and Co (p = 0.01) were greater in fetal liver from VTM than NoVTM. Mo (p ≤ 0.04) and Co (p < 0.01) were affected by GAIN, with greater concentrations in fetal liver from LG than MG. In fetal muscle, Se (p = 0.02) and Zn (p < 0.01) were greater for VTM than NoVTM. Additionally, Zn in fetal muscle was affected by GAIN (p < 0.01), with greater concentrations in LG than MG. The ALF in VTM heifers (p < 0.01) had greater Se and Co than NoVTM. In AMF, trace mineral concentrations were not affected (p ≥ 0.13) by VMSUP, GAIN, or their interaction. Collectively, these data suggest that maternal nutrition pre-breeding and in the first trimester of gestation affects fetal reserves of some trace minerals, which may have long-lasting impacts on offspring performance and health.

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Section: Discussionmentioning

confidence: 99%

Vitamin and Mineral Supplementation and Rate of Gain in Beef Heifers II: Effects on Concentration of Trace Minerals in Maternal Liver and Fetal Liver, Muscle, Allantoic, and Amniotic Fluids at Day 83 of Gestation

McCarthy

Menezes

Kassetas

et al. 2022

Animals

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“…Thirteen of the CpGs associated with maternal Mo have previously been related to gestational age (Figure S5A; Table S3) . Human exposure to Mo may occur via diet, water consumption, inhalation from molybdenum fertilizer, nanoparticles, and/or occupational exposure from mining operations or other industrial uses (Mohamed et al, 2020; Novotny and Peterson, 2018; Vázquez-Salas et al, 2014). It is generally believed that Mo is safe for human health (Novotny and Peterson, 2018).…”

Section: Resultsmentioning

confidence: 99%

“…However, there is growing evidence that excess of Mo is associated with some adverse health outcomes in the general population (Meeker et al, 2008, 2010) and with developmental effects in utero (Gauglitz et al, 2020; Vázquez-Salas et al, 2014; Yin et al, 2020; Zheng et al, 2020). Reproductive and genotoxic effects of Mo have been reported in animals with retarded fetal growth (Mohamed et al, 2020; Tallkvist and Oskarsson, 2015). This points to the possible importance of Mo exposure during pregnancy and DNA methylation patterns with possible long-lasting impact on the child molecular phenotype.…”

Section: Resultsmentioning

confidence: 99%

Multi-omics signatures of the human early life exposome

Maitre

Hernández-Ferrer

Thiel

et al. 2021

Preprint

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Environmental exposures during early life play a critical role in life-course health, yet the molecular phenotypes underlying environmental effects on health are poorly understood. In the Human Early Life Exposome (HELIX) project, a multi-centre cohort of 1,301 mother-child pairs, we associated individual exposomes consisting of >100 chemical, physical and lifestyle exposures assessed in pregnancy and childhood, with multi-omics profiles (methylome, transcriptome, metabolome and proteins) in childhood. We identified 1,170 associations, 249 in pregnancy and 921 in childhood, which revealed potential biological responses and sources of exposure. The methylome best captures the persistent influence of pregnancy exposures, including maternal smoking; while childhood exposures were associated with features from all omics layers, revealing novel signatures for indoor air quality, essential trace elements, endocrine disruptors and weather conditions. This study provides a unique resource (https://helixomics.isglobal.org/) to guide future investigation on the biological effects of the early life exposome.

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“…Likewise, the genetic expressions of E–cadherin and N–cadherin, which controls skeletal tissue developments, were increased in female mouse tissues when molybdenum NPs were given to them or to their fetuses. Hence, it was concluded that orally administered molybdenum NPs can induce genotoxic implications and can cause fetal anomalies which necessitate further in-depth research into their probable toxicological outcomes ( Mohamed et al, 2020 ).…”

Section: Consequences Of Nanoparticle Toxicity On Fetal Abnormalitiesmentioning

confidence: 99%

Safety and Toxicity Implications of Multifunctional Drug Delivery Nanocarriers on Reproductive Systems In Vitro and In Vivo

Ahmad

2022

Front. Toxicol.

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In the recent past, nanotechnological advancements in engineered nanomaterials have demonstrated diverse and versatile applications in different arenas, including bio-imaging, drug delivery, bio-sensing, detection and analysis of biological macromolecules, bio-catalysis, nanomedicine, and other biomedical applications. However, public interests and concerns in the context of human exposure to these nanomaterials and their consequential well-being may hamper the wider applicability of these nanomaterial-based platforms. Furthermore, human exposure to these nanosized and engineered particulate materials has also increased drastically in the last 2 decades due to enormous research and development and anthropocentric applications of nanoparticles. Their widespread use in nanomaterial-based industries, viz., nanomedicine, cosmetics, and consumer goods has also raised questions regarding the potential of nanotoxicity in general and reproductive nanotoxicology in particular. In this review, we have summarized diverse aspects of nanoparticle safety and their toxicological outcomes on reproduction and developmental systems. Various research databases, including PubMed and Google Scholar, were searched for the last 20 years up to the date of inception, and nano toxicological aspects of these materials on male and female reproductive systems have been described in detail. Furthermore, a discussion has also been dedicated to the placental interaction of these nanoparticles and how these can cross the blood–placental barrier and precipitate nanotoxicity in the developing offspring. Fetal abnormalities as a consequence of the administration of nanoparticles and pathophysiological deviations and aberrations in the developing fetus have also been touched upon. A section has also been dedicated to the regulatory requirements and guidelines for the testing of nanoparticles for their safety and toxicity in reproductive systems. It is anticipated that this review will incite a considerable interest in the research community functioning in the domains of pharmaceutical formulations and development in nanomedicine-based designing of therapeutic paradigms.

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Induction of fetal abnormalities and genotoxicity by molybdenum nanoparticles in pregnant female mice and fetuses

Cited by 17 publications

References 27 publications

Vitamin and Mineral Supplementation and Rate of Gain in Beef Heifers II: Effects on Concentration of Trace Minerals in Maternal Liver and Fetal Liver, Muscle, Allantoic, and Amniotic Fluids at Day 83 of Gestation

Vitamin and Mineral Supplementation and Rate of Gain in Beef Heifers II: Effects on Concentration of Trace Minerals in Maternal Liver and Fetal Liver, Muscle, Allantoic, and Amniotic Fluids at Day 83 of Gestation

Multi-omics signatures of the human early life exposome

Safety and Toxicity Implications of Multifunctional Drug Delivery Nanocarriers on Reproductive Systems In Vitro and In Vivo

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