Induction of Fear by Intraoperative Stimulation During Awake Craniotomy: Case Presentation and Systematic Review of the Literature

Nowacki, Andreas; Seidel, Kathleen; Schucht, Philippe; Schindler, Kaspar; Abela, Eugenio; Heinemann, Dorothea; Gutbrod, Klemens; Wiest, Roland; Raabe, Andreas; Pollo, Claudio

doi:10.1016/j.wneu.2015.03.056

Cited by 7 publications

(3 citation statements)

References 28 publications

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“…This multidisciplinary team should not only include medical doctors; instead, an NP is considered a highly valuable member who is at least partially responsible for neuropsychological and neurocognitive patient assessment and selection of patients suitable for awake surgery. In this context, the importance of the preoperative selection process for patients who might be suitable for an awake procedure and the detailed information given to these patients about the upcoming surgery have already been described ( 11 , 38 ). Overall, a thorough preoperative assessment can increase the patients’ compliance and reduce fear before and during surgery ( 11 , 38 ).…”

Section: Discussionmentioning

confidence: 99%

“…Regarding the preoperative phase, the NP is strongly involved in patient selection and preparation prior to awake surgery as aforementioned. Such preoperative NP support can increase the overall success of surgery by increasing compliance and reducing fear ( 11 , 38 ). Concerning the postoperative phase, the NP can overtake or guide important aspects of neurorehabilitation, which have to be considered important parts of modern neuro-oncological treatment concepts ( 29 , 30 ).…”

Section: Discussionmentioning

confidence: 99%

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Resection of Gliomas with and without Neuropsychological Support during Awake Craniotomy—Effects on Surgery and Clinical Outcome

et al. 2017

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Background: During awake craniotomy for tumor resection, a neuropsychologist (NP) is regarded as a highly valuable partner for neurosurgeons. However, some centers do not routinely involve an NP, and data to support the high influence of the NP on the perioperative course of patients are mostly lacking.Objective: The aim of this study was to investigate whether there is a difference in clinical outcomes between patients who underwent awake craniotomy with and without the attendance of an NP.Methods: Our analysis included 61 patients, all operated on for resection of a presumably language-eloquent glioma during an awake procedure. Of these 61 cases, 47 surgeries were done with neuropsychological support (NP group), whereas 14 surgeries were performed without an NP (non-NP group) due to a language barrier between the NP and the patient. For these patients, neuropsychological assessment was provided by a bilingual resident.results: Both groups were highly comparable regarding age, gender, preoperative language function, and tumor grades (glioma WHO grades 1-4). Gross total resection (GTR) was achieved more frequently in the NP group (NP vs. non-NP: 61.7 vs. 28.6%, P = 0.04), which also had shorter durations of surgery (NP vs. non-NP: 240.7 ± 45.7 vs. 286.6 ± 54.8 min, P < 0.01). Furthermore, the rate of unexpected tumor residuals (estimation of the intraoperative extent of resection vs. postoperative imaging) was lower in the NP group (NP vs. non-NP: 19.1 vs. 42.9%, P = 0.09), but no difference was observed in terms of permanent surgery-related language deterioration (NP vs. non-NP: 6.4 vs. 14.3%, P = 0.48).

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Resection of Gliomas with and without Neuropsychological Support during Awake Craniotomy—Effects on Surgery and Clinical Outcome

et al. 2017

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“…Fear was elicited in our study by stimulation of the right middle cingulate gyrus, the left amygdala, the left parietal operculum, and the right hippocampus. Self-reported experience of fear has been evoked by ECS of the amygdala, 31,44 insula, 45,46 inferior temporal cortex, 47 middle temporal cortex, 31 superior temporal cortex, 48 basal temporal cortex, 49 hippocampus, 50,51 middle frontal cortex, 46 and frontal operculum. 46 A large number of ECS studies found that the hippocampus and the amygdala were associated with fear, 31,44,52,53 but did not distinguish whether those fear experiences were auras.…”

Section: Fearmentioning

confidence: 99%

Emotional experience elicited by direct electrical stimulation: Case series and literature review

et al. 2023

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Objective The cortical representation of emotions is complex, and cortical mapping of emotional experience is incomplete. We aimed to contribute to cortical mapping of emotional experience. Methods Clinical data from 400 patients with medically refractory epilepsy who underwent stereo‐electroencephalography implantation for localization of the epileptogenic zone at the Beijing Institute of Functional Neurosurgery between October 2015 and June 2021 were collected retrospectively. Furthermore, we reviewed studies that described cortical mapping of emotional experience through electrical cortical stimulation (ECS). Affective responses similar to ictal aura and electrode contacts located in the SOZ were excluded to investigate emotional experiences in normal brain regions. Results Emotional experiences were evoked by stimulation at 10 electrode contacts in the seven patients, including five contacts that evoked mirth and excitement, one contact that evoked calmness, three contacts that evoked fear, and one contact that evoked sadness. In addition, 21 studies that evaluated emotional experiences in response to cortical electrical stimulation were reviewed. Emotions were distributed in the amygdala, hippocampus, temporal lobe, frontal lobe, insula, frontal operculum, parietal operculum, and cingulate cortex. Significance We provided additional evidence that brain regions including the amygdala, hippocampus, temporal lobe, frontal lobe, insula, frontal operculum, parietal operculum, and cingulate cortex were associated with emotional experience.

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Refractory photophobia elicited during awake craniotomy for the resection of a temporal high-grade glioma

Stauffer

Tortora

Marbacher

et al. 2022

Journal of Clinical Anesthesia

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Induction of Fear by Intraoperative Stimulation During Awake Craniotomy: Case Presentation and Systematic Review of the Literature

Cited by 7 publications

References 28 publications

Resection of Gliomas with and without Neuropsychological Support during Awake Craniotomy—Effects on Surgery and Clinical Outcome

Resection of Gliomas with and without Neuropsychological Support during Awake Craniotomy—Effects on Surgery and Clinical Outcome

Emotional experience elicited by direct electrical stimulation: Case series and literature review

Refractory photophobia elicited during awake craniotomy for the resection of a temporal high-grade glioma

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