Induction of Expression of p75 Neurotrophin Receptor Intracellular Domain Does Not Induce Expression or Enhance Activity of Mitochondrial Complex II

Yang, Yaoli Pu; Lotta, Louis T.; Beutner, Gisela; Li, Xingguo; Schor, Nina F.

doi:10.1155/2016/8752821

Cited by 3 publications

(4 citation statements)

References 12 publications

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“…p75NTR ICD exerts several functions, ranging from survival to cell death, in relation to the co-receptors and/or the type of ligands [ 68 ]. In addition, recent reports indicated that p75NTR ICD may translocate to the nucleus, possibly regulating gene expression [ 7 , 68 , 69 , 70 ].…”

Section: Neurotrophins: From Cell Signaling To Metabolic Processesmentioning

confidence: 99%

Neurotrophins as Key Regulators of Cell Metabolism: Implications for Cholesterol Homeostasis

Colardo

Martella

Pensabene

et al. 2021

IJMS

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Neurotrophins constitute a family of growth factors initially characterized as predominant mediators of nervous system development, neuronal survival, regeneration and plasticity. Their biological activity is promoted by the binding of two different types of receptors, leading to the generation of multiple and variegated signaling cascades in the target cells. Increasing evidence indicates that neurotrophins are also emerging as crucial regulators of metabolic processes in both neuronal and non-neuronal cells. In this context, it has been reported that neurotrophins affect redox balance, autophagy, glucose homeostasis and energy expenditure. Additionally, the trophic support provided by these secreted factors may involve the regulation of cholesterol metabolism. In this review, we examine the neurotrophins’ signaling pathways and their effects on metabolism by critically discussing the most up-to-date information. In particular, we gather experimental evidence demonstrating the impact of these growth factors on cholesterol metabolism.

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Section: Neurotrophins: From Cell Signaling To Metabolic Processesmentioning

confidence: 99%

Neurotrophins as Key Regulators of Cell Metabolism: Implications for Cholesterol Homeostasis

Colardo

Martella

Pensabene

et al. 2021

IJMS

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“…Subsequently, we checked for putative molecular mechanisms explaining the proNGF-induced metabolic shift. Experimental evidence highlights that both p75NTR FL and p75ICD may translocate to the nucleus and regulate gene transcription [ 30 , 36 ]. Furthermore, NGF/proNGF stimulation enhances p75NTR processing and translocation into the nuclear compartment [ 37 ].…”

Section: Resultsmentioning

confidence: 99%

ProNGF/p75NTR Axis Drives Fiber Type Specification by Inducing the Fast-Glycolytic Phenotype in Mouse Skeletal Muscle Cells

Pallottini

Colardo

Tonini

et al. 2020

Cells

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Despite its undisputable role in the homeostatic regulation of the nervous system, the nerve growth factor (NGF) also governs the relevant cellular processes in other tissues and organs. In this study, we aimed at assessing the expression and the putative involvement of NGF signaling in skeletal muscle physiology. To reach this objective, we employed satellite cell-derived myoblasts as an in vitro culture model. In vivo experiments were performed on Tibialis anterior from wild-type mice and an mdx mouse model of Duchenne muscular dystrophy. Targets of interest were mainly assessed by means of morphological, Western blot and qRT-PCR analysis. The results show that proNGF is involved in myogenic differentiation. Importantly, the proNGF/p75NTR pathway orchestrates a slow-to-fast fiber type transition by counteracting the expression of slow myosin heavy chain and that of oxidative markers. Concurrently, proNGF/p75NTR activation facilitates the induction of fast myosin heavy chain and of fast/glycolytic markers. Furthermore, we also provided evidence that the oxidative metabolism is impaired in mdx mice, and that these alterations are paralleled by a prominent buildup of proNGF and p75NTR. These findings underline that the proNGF/p75NTR pathway may play a crucial role in fiber type determination and suggest its prospective modulation as an innovative therapeutic approach to counteract muscle disorders.

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“…Also, induction of p75NTR expression does not result in a consistent change across neuroblastoma cell lines in expression of the retinoid binding protein, CRABP-I. 31,32 Potentiation by p75NTR of redox stress and apoptosis induction by 4-HPR requires p38MAPK phosphorylation, JNK phosphorylation, caspase 3 activation, Akt cleavage, and a decrease in Akt phosphorylation. 29 It is hypothesized that this pro-apoptotic signaling cascade enhances the generation or half-life of mitochondrial reactive oxygen species at the level of complex II.…”

Section: ■ Asymmetric Dimethylargininementioning

confidence: 91%

“…This enhancement does not involve induction of overexpression or increased activity of complex II. Also, induction of p75NTR expression does not result in a consistent change across neuroblastoma cell lines in expression of the retinoid binding protein, CRABP-I. , …”

Section: Redox Signaling As a Targetmentioning

confidence: 92%

Using Chemistry to Target Neuroblastoma

Hansen

Zheng

et al. 2017

ACS Chem. Neurosci.

Self Cite

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Neuroblastoma is a cancer of the neural crest almost exclusively seen in childhood. While children with single, small primary tumors are often cured with surgery alone, the 65% of children with neuroblastoma whose disease has metastasized have less than a 50% chance of surviving five years after diagnosis. Innovative pharmacological strategies are critically needed for these children. Efforts to identify novel targets that afford ablation of neuroblastoma with minimal toxicity to normal tissues are underway. Developing approaches to neuroblastoma include those that target the catecholamine transporter, ubiquitin E3 ligase, the ganglioside GD2, the retinoic acid receptor, the protein kinases ALK and Aurora, and protein arginine N-methyltransferases. Here, as examples of the use of chemistry to combat neuroblastoma, we describe targeting of the protein arginine N-methyltransferases and their role in prolonging the half-life of the neuroblastoma oncoprotein N-Myc, redox signaling in neuroblastoma, and developmentally regulated proteins expressed in primitive neuroblastoma cells but not in mature neural crest elements.

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Induction of Expression of p75 Neurotrophin Receptor Intracellular Domain Does Not Induce Expression or Enhance Activity of Mitochondrial Complex II

Cited by 3 publications

References 12 publications

Neurotrophins as Key Regulators of Cell Metabolism: Implications for Cholesterol Homeostasis

Neurotrophins as Key Regulators of Cell Metabolism: Implications for Cholesterol Homeostasis

ProNGF/p75NTR Axis Drives Fiber Type Specification by Inducing the Fast-Glycolytic Phenotype in Mouse Skeletal Muscle Cells

Using Chemistry to Target Neuroblastoma

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