Induction of experimental autoimmune arthritis by a public epitope of the T cell receptor variable α  domain of an arthritogenic T cell clone

Tienhoven, Esther A.E. van; Kooten, Peter J. S. van; Veenstra, Jetty G.; Hage, M. H. van der; Eden, Willem van; Broeren, Chris P. M.

doi:10.1002/1521-4141(2000)30:18<2164::aid-immu2164>3.3.co;2-n

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…The peptide 66-80 elicits classic delayed-type hypersensitivity, even in naive rats, suggesting that there is a preexisting level of T cell priming, and that this reactivity is increased in rats with AIA. In contrast, nasal application of the antiidiotypic V␣ peptide 66-80 results in a decrease both of subsequent arthritis and the accompanying delayed-type hypersensitivity (50).…”

Section: Regulation Driven By Idiotopes Of Effector T Cell Receptor Osupporting

confidence: 84%

“…Recipients of a transfer of antiidiotype-specific cells become resistant to arthritis induced by M tuberculosis. In contrast to the V␤18 results, immunization of normal animals with V␣11 peptide 66-80 or antiidiotypic cells recognizing V␣11 peptide 66-80 leads to an arthritis (44,50). The peptide 66-80 elicits classic delayed-type hypersensitivity, even in naive rats, suggesting that there is a preexisting level of T cell priming, and that this reactivity is increased in rats with AIA.…”

Section: Regulation Driven By Idiotopes Of Effector T Cell Receptor Omentioning

confidence: 89%

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Immune regulation in adjuvant‐induced arthritis: Possible implications for innovative therapeutic strategies in arthritis

Eden¹,

Waksman²

2003

Arthritis & Rheumatism

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Section: Regulation Driven By Idiotopes Of Effector T Cell Receptor Osupporting

confidence: 84%

Section: Regulation Driven By Idiotopes Of Effector T Cell Receptor Omentioning

confidence: 89%

Immune regulation in adjuvant‐induced arthritis: Possible implications for innovative therapeutic strategies in arthritis

Eden¹,

Waksman²

2003

Arthritis & Rheumatism

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Matrix Metalloproteinases as Targets for the Immune System during Experimental Arthritis

Bilsen

Wagenaar-Hilbers

Grosfeld-Stulemeijer

et al. 2004

The Journal of Immunology

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Novel therapies for rheumatoid arthritis aiming at intervention in the inflammatory process by manipulation of autoreactive T and B lymphocytes receive major interest. However, the development of such therapies is largely hampered by the lack of knowledge of self-Ags recognized during the disease process. Recently, we predicted putative T cell self-epitopes based on a computer search profile. In the present study, the predicted self-epitopes were tested for T cell recognition in two experimental arthritis models, and their arthritogenic capacity was analyzed. Fourteen of n = 51 predicted self-epitopes were recognized during experimental arthritis of which six were able to actively induce arthritis. Interestingly, three of these six peptides were derived from matrix metalloproteinases (MMP), and only T cells responsive to MMP-derived epitopes were able to passively transfer arthritis to naive rats. Moreover, we demonstrate the presence of Abs to MMP-3 during the course of adjuvant arthritis. Together these data indicate that MMPs play a pivotal role as target for T and B cells during the development of inflammatory arthritis. This finding sheds new light on the pathophysiological role of MMPs during arthritis and opens novel possibilities for Ag-specific immunotherapy.

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Induction of experimental autoimmune arthritis by a public epitope of the T cell receptor variable α domain of an arthritogenic T cell clone

Cited by 2 publications

References 15 publications

Immune regulation in adjuvant‐induced arthritis: Possible implications for innovative therapeutic strategies in arthritis

Immune regulation in adjuvant‐induced arthritis: Possible implications for innovative therapeutic strategies in arthritis

Matrix Metalloproteinases as Targets for the Immune System during Experimental Arthritis

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