Induction of endometriosis alters the peripheral and endometrial regulatory T cell population in the non-human primate

Braundmeier, Andrea G.; Jackson, Kevin; Hastings, Julie M.; Koehler, J. S.; Nowak, Romana A.; Fazleabas, Asgerally T.

doi:10.1093/humrep/des083

Cited by 46 publications

(41 citation statements)

References 85 publications

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“…The failure to implant embryos associated with endometriosis was transferrable in the peritoneal fluid (PF) in rabbits (35), as well as in mice who received human endometriotic PF (36). Induction of endometriosis in the baboon has been shown to be associated with gradual but profound alterations in the endometrium over time (37), suggesting that inflammation and the immune system may be involved in these changes.…”

Section: Endometriosis and Infertility – What Is The Evidence?mentioning

confidence: 99%

Endometrial receptivity in the eutopic endometrium of women with endometriosis: it is affected, and let me show you why

Lessey¹,

Kim²

2017

Fertility and Sterility

207

155

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The endometrium maintains complex controls on proliferation and apoptosis as part of repetitive menstrual cycles that prepare the endometrium for the window of implantation and pregnancy. The reliance on inflammatory mechanisms for both implantation and menstruation, creates the opportunity in the setting of endometriosis for the establishment of chronic inflammation that is disruptive to endometrial receptivity, causing both infertility and abnormal bleeding. Clinically, there can be little doubt that the endometrium of women with endometriosis is less receptive to embryo implantation, and strong evidence exists to suggests that endometrial changes are associated with decreased cycle fecundity as a result of this disease. Here we provide unifying concepts regarding those changes and how they are coordinated to promote progesterone resistance and estrogen dominance through aberrant cell signaling pathways and reduced expression of key homeostatic proteins in eutopic endometrium of women with endometriosis.

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Section: Endometriosis and Infertility – What Is The Evidence?mentioning

confidence: 99%

Endometrial receptivity in the eutopic endometrium of women with endometriosis: it is affected, and let me show you why

Lessey¹,

Kim²

2017

Fertility and Sterility

207

155

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“…Lower numbers of Treg cells have been detected in the eutopic endometrium of a non-human primate endometriosis model [44]. Interestingly, in humans, the expression of the transcription factor forkhead P3 (Foxp3), a distinctive surface marker for Treg cells, is upregulated in the endometrium of women with endometriosis [45].…”

Section: Inflammation Immune Dysfunction and Infertilitymentioning

confidence: 99%

Implications of immune dysfunction on endometriosis associated infertility

et al. 2016

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Endometriosis is a complex, inflammatory disease that affects 6-10% of reproductive-aged women. Almost half of the women with endometriosis experience infertility. Despite the excessive prevalence, the pathogenesis of endometriosis and its associated infertility is unknown and a cure is not available. While many theories have been suggested to link endometriosis and infertility, a consensus among investigators has not emerged. In this extensive review of the literature as well as research from our laboratory, we provide potential insights into the role of immune dysfunction in endometriosis associated infertility. We discuss the implication of the peritoneal inflammatory microenvironment on various factors that contribute to infertility such as hormonal imbalance, oxidative stress and how these could further lead to poor oocyte, sperm and embryo quality, impaired receptivity of the endometrium and implantation failure.

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“…Patients with endometriosis have elevated levels of immune mediators in the peritoneal fluid, which is believed to occur as a result of improper ectopic tissue clearance [13][14][15]. Women with endometriosis have been shown to have reduced T regulatory cell populations in both the periphery and within the endometrium [16], as well as increased T regulatory cells in ectopic endometrial tissue [17], creating an immunosuppressive microenvironment that allows for endometriotic lesions to survive. Together, these data suggest endometriosis may be characterized as an immune disorder with autoimmune and chronic inflammatory tendencies.…”

Section: Introductionmentioning

confidence: 99%

Reproductive Microbiomes: Using the Microbiome as a Novel Diagnostic Tool for Endometriosis

Cregger¹,

Lenz²,

Leary³

et al. 2017

Reproductive Immunol Open Acc

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Induction of endometriosis alters the peripheral and endometrial regulatory T cell population in the non-human primate

Cited by 46 publications

References 85 publications

Endometrial receptivity in the eutopic endometrium of women with endometriosis: it is affected, and let me show you why

Endometrial receptivity in the eutopic endometrium of women with endometriosis: it is affected, and let me show you why

Implications of immune dysfunction on endometriosis associated infertility

Reproductive Microbiomes: Using the Microbiome as a Novel Diagnostic Tool for Endometriosis

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