Induction of Endogenous Interferon by Use of Standard Live Vaccines for Prevention of Respiratory Viral Infections

Smorodintsev, A. A.; Gvozdilova, D. A.; Romanov, Yury A.; Makarjev, Georgy S.; Rudenko, V. I.; Aksenov, O A; Zlydnikov, D M

doi:10.1111/j.1749-6632.1970.tb53474.x

Cited by 8 publications

(3 citation statements)

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“…(17) BACKGROUND What are the concentrations of IFN naturally occurring in the nasal and oral cavity? IFN has been identified in pharyngeal washings, (18) saliva, (19) or nasal washings (20)(21)(22)(23)(24)(25)(26)(27)(28)(29) of humans, in the nasal washings (30) and nasal secretions (31)(32)(33)(34)(35) of cattle, and in the nasal washings of cats. (36) An IFN titer of 2,048 units/ml was reported in the nasal washing of a human subject grin-b 1.…”

Section: Introductionmentioning

confidence: 99%

Oral Use of Interferon

Cummins¹,

Beilharz²,

Krakowka³

1999

Journal of Interferon & Cytokine Research

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Interferon-alpha (IFN-alpha) given orally has biological activity in humans and other animals. The dose providing the most benefit delivers IFN-alpha to the oral mucosa in a concentration (10(2)-10(3) IU), similar to that naturally produced in the nasal secretions during respiratory infections. In contrast, conventional IFN therapy employs parenteral doses of > 10(6) IU and, for this reason, orally administered IFN therapies have been called low-dose treatments. Efficacy in both animal disease models and human studies has been reported, and the mechanisms whereby oral administration has a systemic effect are under active study in a number of laboratories.

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Section: Introductionmentioning

confidence: 99%

Oral Use of Interferon

Cummins¹,

Beilharz²,

Krakowka³

1999

Journal of Interferon & Cytokine Research

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“…It is thus perhaps not surprising that in this study, interferon was detected in 33.3 % of subjects who developed a significant HI antibody response following intranasal administration of live attenuated influenza A/England/42/72 (H3N2) vaccine, but in none of the subjects following poliovirus vaccine administration. The latter finding is at variance with reports in the Russian literature where interferon response had been reported following both polio type 2 and "live enteroviral vaccine" (LEV) comprising ECHO viruses (6,7). The explanation for this is not readily apparent, but is unlikely to be due to the insensitivity of our interferon assay system because the British human interferon standard A 69/19 which contains approximately 5000 units was found to have 5990 units of interferon in our assay.…”

mentioning

confidence: 70%

Induction of Interferon in Man by Vaccines

Rytel¹

1975

Experimental Biology and Medicine

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“…At the population level, it has been noted that during trials of live attenuated IFV (LAIV) vaccines, an interferon (IFN) response was triggered that protected vaccinees against off-target viruses for 7 days postvaccination [ 249 ]. This 1970 study went so far as to suggest such effects could be maintained for a prolonged period using a regime of consecutive schedule vaccinations, each separated by 7 days or more, during times of a prolonged epidemic [ 249 ]. A similar effect was produced using live EV vaccines (LEV) to replace pathogenic EV types and interrupt outbreaks [ 250 ].…”

Section: Virus Interference and The Hrvsmentioning

confidence: 99%