Induction of developmental toxicity and cardiotoxicity in zebrafish embryos by Emamectin benzoate through oxidative stress

Lu, Jian; Wang, Weiguo; Xu, Wenping; Zhang, Chenggong; Zhang, Cheng; Tao, Liming; Li, Zhong; Zhang, Yang

doi:10.1016/j.scitotenv.2022.154040

Cited by 34 publications

(19 citation statements)

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“…As heart development occurs in an early stage, blood flows normally and the blood vessels already develop (Burggren, 2013;. We also confirmed the abnormalities in the zebrafish larvae heart by measuring the distance between the SV and BA, which are used to evaluate cardiotoxicity and cardiac circulation (Cui et al, 2016;Lu et al, 2022). The distance between the SV and BA dramatically increased, and the heart rate decreased in the mecoprop-p-treated zebrafish larvae.…”

Section: Discussionsupporting

confidence: 69%

Mecoprop-p interrupts the development of zebrafish via apoptosis and vascular damage

Park

et al. 2022

J Anim Reprod Biotechnol

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To regulate the growth of broad leaf weeds in crop fields, chlorophenoxy herbicides, including dicamba, mecoprop, mecorpop-p, and 4-chloro-2-methylphenoxyacetic acid, are widely used (Sanchis et al., 2013;Mottier et al., 2014). The toxicities of several chlorophenoxy herbicides have been reported despite their widespread use. For example, 2,4-dichlorophenoxyacetic acid can cause cerebrovascular impairments in rats by damaging the structure of the plasma membrane (Elo et al., 1988;Bradberry et al., 2000). Mecoprop-p, another chlorophenoxy herbicide, is a synthetic auxin that has been widely used to control weed growth since the 1980s (Périllon et al., 2021). It is known to be poorly absorbed in the soil but has a high water solubility of 250 mg/L at 20℃

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Section: Discussionsupporting

confidence: 69%

Mecoprop-p interrupts the development of zebrafish via apoptosis and vascular damage

Park

et al. 2022

J Anim Reprod Biotechnol

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“…7 Previous evidences have confirmed the toxicity effect of EMB on the non-target organism, manifesting reproductive health, 8 kidney function, 9 hepatotoxicity, 10,11 neurobehavioral toxicity, 12,13 developmental toxicity, and cardiotoxicity. 14 Despite the toxic effects of EMB have been reported, EMB-induced immunotoxicity risk to human remains poorly understood.…”

Section: Introductionmentioning

confidence: 99%

The potential immunotoxicity of emamectin benzoate on the human THP‐1 macrophages

Wei

Wang

et al. 2022

Environmental Toxicology

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Emamectin benzoate (EMB) as one of the typical biological pesticides has a wide range of applications in agriculture. However, the immune toxic effects of EMB in human received limited attention. In our study, THP-1 macrophage as an in vitro model was used to evaluate immune functions exposed to EMB. We observed that EMB inhibited phagocytic activity and respiratory burst capacity of macrophages without inducing cellular toxicity, implying the potential immunosuppression.Besides, EMB disturbed the cytokines balance embodied in the increase of TNF-α, IL-1β, IL-6, CCL27, CXCL8 mRNA expression and the decrease of IL-4, IL-13, IL-10 mRNA expression. EMB could exhibit pro-inflammatory responses in macrophages and promote the conversion of macrophages to M1 phenotype. Moreover, NF-κB pathway involved in regulating immune function from KEGG pathway analysis. EMB exposure could activate the NF-κB pathway in THP-1 macrophages by exploring the critical proteins. This research provided insights on immunotoxicity evaluation and clarified EMB-induced immunotoxicity was related to NF-κB pathway activation.

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“…Pesticides enter aquatic environments and lead to severe ecological and environmental problems. EB shows high toxicity to aquatic organisms, 49 and many adjuvants in the formulation are also toxic. 50 In Fig.…”

Section: Resultsmentioning

confidence: 99%

Development of emamectin benzoate-loaded liposome nano-vesicles with thermo-responsive behavior for intelligent pest control

Chen

Ding

et al. 2022

J. Mater. Chem. B

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Induction of developmental toxicity and cardiotoxicity in zebrafish embryos by Emamectin benzoate through oxidative stress

Cited by 34 publications

References 50 publications

Mecoprop-p interrupts the development of zebrafish via apoptosis and vascular damage

Mecoprop-p interrupts the development of zebrafish via apoptosis and vascular damage

The potential immunotoxicity of emamectin benzoate on the human THP‐1 macrophages

Development of emamectin benzoate-loaded liposome nano-vesicles with thermo-responsive behavior for intelligent pest control

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