Induction of deletion mutation on ompR gene of Salmonella enterica serovar Typhi isolates from asymptomatic typhoid carriers to evolve attenuated strains for vaccine development

Abstract

This study demonstrates that the S. typhi strains were attenuated and could be good vaccine candidates in future.

Simplest identification, O-specific polysaccharide purification and antigenic evaluation of Salmonella enterica serovar Typhi Vi negative isolate

“…Vaccine based on Vi polysaccharide will not protect patients if the invader S. Typhi is negative for Vi (Senthilkumar et al, 2014[ 15 ]). So it is imperative to target antigens which are universally present in all S. Typhi.…”

Medical Microbiology in India: the recent developments in the basic research, diagnostics and vaccines

“…In animal studies, the recombinant Omp-28 protein elicited strong protection against virulent Salmonella typhi (Saxena et al, 2017). OmpR attenuated strains of S. typhi may be used as good candidate strains for the development of live attenuated vaccine against salmonellosis (Senthilkumar et al, 2014).…”