Induction of cytokine genes and IL-1α by chemical hypoxia in PC12 cells

Possible Role of Interleukin-6 in PC12 Cell Death Induced by MPP+ and Tetrahydroisoquinoline

“…The constitutive expression of IL-1a and IL-6 mRNAs is shown in PC12 cells (21,22). In our experiment, the constitutive expressions of IL-1a and IL-6 mRNAs in PC12 cells were demonstrated (Fig.…”

“…It is reported that expression of IL-6 mRNA in PC12 cells increased not only by physiological stimulations such as depolarization (22), but also by chemical hypoxia (21). In neuronal cells including PC12 cells, the dopaminergic neurotoxins such as MPP + , oxidized dopamine and 6-hydroxydopamine regulate various gene expressions (9, 24, 32 -34).…”

Ethanol induces the production of cytokines via the Ca2+, MAP kinase, HIF-1α, and NF-κB pathway

“…Increased Ca 2+ induces the release of biological mediators including TNF-a, IL-1, IL-6 and TGFh1 (Jeong et al, 2002;Liu et al, 2000;Ding et al, 2000;Andersson and Sundler, 2000). In this study, human mast cell line, HMC-1 cells, was treated with ethanol for 3 min and then [Ca 2+ ] i was measured.…”

Cooperative Autocrine and Paracrine Functions of Granulocyte Colony-Stimulating Factor and Granulocyte-Macrophage Colony-Stimulating Factor in the Progression of Skin Carcinoma Cells

“…Such selection by the in vivo environment is supposedly induced by adverse environmental conditions, e.g., hypoxia, low pH, and nutrient deprivation. In this context, a hypoxia-induced expression of IL-1 may initially contribute to an activation of G-CSF and GM-CSF expression in tumor cells (39). Eventually, that activation may become constitutive through the mutational influences that the hypoxic, low pH tumor stroma exerts on the tumor cells (40,41).…”