Induction of cytochrome P-450 and P-448 in the outer membrane of mouse liver nuclei by phenobarbital and benzo [α-]pyrene

Time course of the induction of aryl hydrocarbon hydroxylase in rat liver nuclei and microsomes by phenobarbital, 3-methylcholanthrene, 2,3,7,8-tetrachloro-dibenzo-p-dioxin, dieldrin and other inducers

“…AHH holds a centrat place in the metabolism of foreign compounds and in the activation of chemical carcinogens to electrophilic metabolites, especially of PAH [4][5][6][7]. In mammalian liver, AHH is found in the ER, but also, with much Jess activity, in the outer membrane of the nucJeus, and the binding of P AH to protein and ON A can be catalyzed by microsomes as weH as by isolated nuclei (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). AHH can be induced by a variety of substances and it has been established that the extent of binding of PAH to protein and DNA in vitro is correlated to the induction of AHH in microsomes, nuclei or both [14,15,17,19].…”