Induction of CYP1A2 by heavy coffee consumption is associated with the CYP1A2 −163C&gt;A polymorphism

Djordjević, Nataša; Ghotbi, Roza; Janković, Slobodan; Aklillu, Eleni

doi:10.1007/s00228-010-0823-4

Cited by 89 publications

(74 citation statements)

References 27 publications

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“…In a subset of the present study cohort, it has previously been shown that moderate to high coffee intake modulates ER status in women with the CYP1A2*1F A/A genotype, but not in those with the CYP1A2*1F C-allele [18]. The CYP1A2 enzyme is more inducible by coffee in CYP1A2*1F A/A carriers [19,20]. It is therefore plausible that tamoxifen response is influenced by the CYP1A2*1F genotype and coffee intake and that any effect of coffee may be dependent on the CYP1A2*1F genotype.…”

Section: Introductionmentioning

confidence: 57%

“…Intake of caffeinated coffee may thus result in increased activation of tamoxifen via CYP1A2 or CYP2C8/9, a hypothesis consistent with our finding of fewer early events in tamoxifen-treated patients with ER+ tumors and moderate to high coffee consumption. Moreover, others have reported that carriers of the CYP1A2*1F A/A genotype but not the CYP1A2*1F C-allele who consume 3+ cups/day have a higher inducibility of CYP1A2 compared to non-consumers [20]. This may explain the finding of an association between low coffee consumption in combination with at least one CYP1A2*IF Callele or CYP2C8*3 allele with an over 3-fold risk for early breast cancer events in tamoxifen-treated patients with ER+ tumors.…”

Section: Discussionmentioning

confidence: 99%

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Coffee prevents early events in tamoxifen-treated breast cancer patients and modulates hormone receptor status

Simonsson

Söderlind

Henningson

et al. 2013

Cancer Causes Control

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Coffee prevents early events in tamoxifen-treated breast cancer patients and modulates hormone receptor status.Simonsson, Maria; Söderlind, Viktoria; Henningson, Maria; Hjertberg, Maria; Rose, Carsten; Ingvar, Christian; Jernström, Helena General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Moderate to high coffee consumption was associated with significantly decreased risk for early events in tamoxifen-treated patients and modified hormone receptor status. If confirmed, new recommendations regarding coffee consumption during tamoxifen-treatment may be warranted.

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Section: Introductionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Coffee prevents early events in tamoxifen-treated breast cancer patients and modulates hormone receptor status

Simonsson

Söderlind

Henningson

et al. 2013

Cancer Causes Control

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“…An A → C polymorphism of the CYP1A2 has been associated with [87,88]. Those with the homozygous A/A allele have been found to metabolise caffeine faster than C allele carriers (A/C and C/C); homozygous C/C individuals have the slowest caffeine metabolism [88][89][90]. A slower caffeine metabolism such as that found in A/C and C/C allele carriers could result in a longer half-life thus prolonging the ergogenic effect of caffeine whereas faster metabolism would result in a faster breakdown of caffeine, reducing the half-life of caffeine in the body.…”

Section: Discussionmentioning

confidence: 99%

Correction to: The Effect of Acute Caffeine Ingestion on Endurance Performance: A Systematic Review and Meta-Analysis

2018

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Introduction Caffeine is a widely used ergogenic aid with most research suggesting it confers the greatest effects during endurance activities. Despite the growing body of literature around the use of caffeine as an ergogenic aid, there are few recent meta-analyses which quantitatively assess the effect of caffeine on endurance exercise. Objectives To summarise studies which have investigated the ergogenic effects of caffeine on endurance time-trial performance and to quantitatively analyse the results of these studies to gain a better understanding of the magnitude of caffeine's ergogenic effect on endurance time-trial performance. Methods A systematic review was carried out on randomised placebo-controlled studies investigating the effects of caffeine on endurance performance and a meta-analysis was conducted to determine the ergogenic effect of caffeine on endurance time-trial performance. Results 44 studies met the inclusion criteria and were included in the meta-analysis. Caffeine has a small but evident effect on endurance performance when taken in moderate doses (3-6 mg·kg −1 ) as well as an overall improvement following caffeine compared to placebo in mean power output (2.92 ± 2.18%; Effect Size = 0.22 ± 0.15) and time-trial completion time (2.26 ± 2.60%; Effect Size = 0.28 ± 0.12). However, differences in responses to caffeine ingestion have been shown, with two studies reporting slower time-trial performance while five studies reported lower mean power output during the timetrial. Caffeine can be used effectively as an ergogenic aid when taken in moderate doses, such as during sports when a small increase in endurance performance can lead to significant differences in placements as athletes are often separated by small margins.

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“…40 Furthermore, high coffee consumption has been reported to induce CYP1A2 activity, especially in subjects with two rapid alleles (CYP1A2*1A) and this may have influenced our results. 41,42 It is hypothesized that tea consumption may lower CRC risk through its antioxidant components protecting colonic epithelial cells against oxidative radicals. 43,44 Despite the consistently observed protective effect of tea components in animal studies, a protective effect has, in general, not been demonstrated in epidemiological studies, 11,13 and is further confirmed by the present study.…”

Section: Discussionmentioning

confidence: 99%

Coffee and tea consumption, genotype-basedCYP1A2andNAT2activity and colorectal cancer risk-Results from the EPIC cohort study

et al. 2013

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Coffee and tea contain numerous antimutagenic and antioxidant components and high levels of caffeine that may protect against colorectal cancer (CRC). We investigated the association between coffee and tea consumption and CRC risk and studied potential effect modification by CYP1A2 and NAT2 genotypes, enzymes involved in the metabolization of caffeine. Data from 477,071 participants (70.2% female) of the European Investigation into Cancer and Nutrition (EPIC) cohort study were analyzed. At baseline (1992–2000) habitual (total, caffeinated and decaffeinated) coffee and tea consumption was assessed with dietary questionnaires. Cox proportional hazards models were used to estimate adjusted hazard ratio's (HR) and 95% confidence intervals (95% CI). Potential effect modification by genotype‐based CYP1A2 and NAT2 activity was studied in a nested case–control set of 1,252 cases and 2,175 controls. After a median follow‐up of 11.6 years, 4,234 participants developed CRC (mean age 64.7 ± 8.3 years). Total coffee consumption (high vs. non/low) was not associated with CRC risk (HR 1.06, 95% CI 0.95–1.18) or subsite cancers, and no significant associations were found for caffeinated (HR 1.10, 95% CI 0.97–1.26) and decaffeinated coffee (HR 0.96, 95% CI 0.84–1.11) and tea (HR 0.97, 95% CI 0.86–1.09). High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non/low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity, which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk. This study shows that coffee and tea consumption is not likely to be associated with overall CRC.

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Induction of CYP1A2 by heavy coffee consumption is associated with the CYP1A2 −163C>A polymorphism

Abstract: CYP1A2 polymorphism -163C>A has an important increasing effect on CYP1A2 inducibility by heavy coffee consumption and may possibly be a contributing factor for interindividual variations in CYP1A2 enzyme activity.

Cited by 89 publications

References 27 publications

Coffee prevents early events in tamoxifen-treated breast cancer patients and modulates hormone receptor status

Coffee prevents early events in tamoxifen-treated breast cancer patients and modulates hormone receptor status

Correction to: The Effect of Acute Caffeine Ingestion on Endurance Performance: A Systematic Review and Meta-Analysis

Coffee and tea consumption, genotype-basedCYP1A2andNAT2activity and colorectal cancer risk-Results from the EPIC cohort study

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