1986
DOI: 10.1111/j.1346-8138.1986.tb02970.x
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Induction of Chronic Skin Changes in Intraperitoneally Hematoporphyrin‐Injected Mice with Metal Halide Lamp Irradiation

Abstract: To induce chronic skin changes simulating human porphyria, mice which had been injected intraperitoneally with hematoporphyrin dihydrochloride were exposed to metal halide lamps. Clinical and histopathological findings in the mice were observed. Clinically, erythema, edema, erosion, necrosis and crust formation were initially seen in all of the mice treated. Hypertrophy of the skin, scarring, and deformities of the ear lobes followed gradually. Histopathological findings in these skin changes were mainly seen … Show more

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