Induction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin

Novel antiproliferative flavonoids induce cell cycle arrest in human prostate cancer cell lines

“…It is the most widely studied flavonoid and has been shown to exert antiproliferative effect on a number of cell lines. [30][31][32] ISLQ, luteolin and quercetin appeared to have greater effect on proliferation in LNCaP than in PC3 cells. In addition, two other flavonoids, 5-methoxyflavone (synthetic) and baicalein (component of PCSPES herbal remedy), had low IC 50 in LNCaP but not PC3 (Table 2).…”

Berry Fruits as a Source of Biologically Active Compounds: The Case of Lonicera Caerulea

“…Numerous reports shows quercetin ability to inhibit proliferation of cancer cell lines in vitro, including breast, colon, pancreas cancer, and leukemia 122 . Its mechanism of action includes induction of apoptosis 123 , inhibition of epidermal growth factor receptor expression and associated tyrosine kinase activity 122 , reduced expression of Ras protein in colon cancer cells and primary colorectal tumors 124 , increased expression of endogenous inhibitors 2β → O →7) found in cranberries can inhibit adherence of uropathogenic P-fi mbriated Escherichia coli (Fig. 6) (ref.…”

Quercetin-induced Growth Inhibition in Human Bladder Cancer Cells Is Associated with an Increase in Ca2+-activated K+Channels

“…The antitumor activity of quercetin has been tested in several cancers including breast [4], colon [5], gastric [6], leukemic [7] and bladder cells [8]. Anticancer actions were attributed to several cellular mechanisms including apoptosis by triggering the generation of ROS [9], and regulation of the cell cycle by modulating several molecular targets including p21 [10], cyclin B [11], p27 [12], and topoisomerase II [13,14]. However the ion channel-related cancer prevention cellular mechanism of quercetin is still not thoroughly understood, especially in bladder cancer cells.…”