Induction of cell cycle arrest and apoptosis by a combined treatment with 13‐<i>cis</i>‐retinoic acid, interferon‐α2a, and α‐tocopherol in squamous cell carcinoma of the head and neck

Zhang, Xin; Chen, Zhuo Georgia; Khuri, Fadlo R.; Shin, Dong M.

doi:10.1002/hed.20525

Cited by 11 publications

(9 citation statements)

References 47 publications

(50 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…22 Also, AT as a single agent or combination with other chemopreventive agents inhibited cellular proliferation and induced apoptosis in cell lines of gastrointestinal tract cancer. 15,23 Our results confirmed the growth inhibitory effect of AX and AT in TE-4 esophageal cancer cell line. However, the fixed concentration of AT (100μM) which inhibited cellular proliferation was higher than that of other study (15μM) which showed such effect in squamous head and neck cancer cell line.…”

Section: Discussionsupporting

confidence: 79%

“…However, the fixed concentration of AT (100μM) which inhibited cellular proliferation was higher than that of other study (15μM) which showed such effect in squamous head and neck cancer cell line. 15 Our findings also suggested that AX and AT as single progression at the G0/G1 phase. 24 Our study showed that AX and AT as a single agents increased the expression of p27, however could not demonstrate accompanying decreased activity of cyclin D1.…”

Section: Discussionsupporting

confidence: 68%

“…[12][13][14] Furthermore, AT showed inhibition of cell proliferation, induction of cell cycle arrest and apoptosis as a single agent or 2-to 3-drug combination. 15 It is interesting that dietary AT exerted antitumoral activity in the post-initiation phase of carcinogen-induced oral cancer models.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Anticancer Effects of Astaxanthin and α-tocopherol in Esophageal Cancer Cell Lines

Lim

Lee

Jung

et al. 2011

Korean J Helicobacter Up Gastrointest Res

View full text Add to dashboard Cite

Background/Aims: Astaxanthin (AX) has been attributed with potential for protecting the organism against different types of cancer due to its anti-oxidant activity. Also several in vivo and in vitro studies suggest certain naturally occurring vitamin E (i.e. α-tocopherol) as promising anticancer agents. We assessed the effect of AX and α-tocopherol (AT) respectively and their combination on human esophageal cancer cell lines to investigate the mechanism of anticancer effect and their therapeutic potential. Materials and Methods: Two human esophageal cancer cell lines (TE-1, TE-4) were exposed to AX (6 to 10μg/mL) and AT (20 to 100μM) for 24 hours. Quantification of proliferation was performed by MTT assay. Cell cycle machinery proteins such as p-AKT, p-p38, cyclin D1, p27 and caspase-3 were investigated by Western blot. Results: Significant inhibition of cell proliferation of AX and AT was observed in TE-4 cell line by a dose-dependent manner. Furthermore, AX and AT as single agents increased the protein expression of p27 and cleaved caspase-3 in TE-4 cell line. The combination of the two agents decreased the expression of cyclin D1, however they did not demonstrate pro-apoptotic effect. Conclusions: AX and AT as single agents are effective at inhibition of cell proliferation and induce apoptosis by the modulation of cell cycle machinery proteins in esophageal cancer cell lines. However, our data could not suggest that their combination has any cooperative apoptotic effect. (Korean J Helicobacter Up Gastrointest Res 2011;11:170-175)

show abstract

Section: Discussionsupporting

confidence: 79%

Section: Discussionsupporting

confidence: 68%

See 1 more Smart Citation

Anticancer Effects of Astaxanthin and α-tocopherol in Esophageal Cancer Cell Lines

Lim

Lee

Jung

et al. 2011

Korean J Helicobacter Up Gastrointest Res

View full text Add to dashboard Cite

show abstract

“…Three-drug combination induced significant accumulation of the cells at S-phase and induced apoptosis. These data supported the promising outcomes of the phase III trial with a combination of these three drugs in patients with advanced head and neck cancer in the adjuvant settings [62].…”

Section: Head and Neck Squamous Cell Carcinoma (Hnscc) (Table 2)mentioning

confidence: 56%

Apoptosis-inducing activity and tumor-specificity of antitumor agents against oral squamous cell carcinoma

Sakagami

2010

Japanese Dental Science Review

View full text Add to dashboard Cite

“…They inhibit the cell proliferation of normal and malignant cells, modulate cell differentiation and trigger apoptosis (14)(15)(16)(17)29,(32)(33)(34). The cells are triggered in a G0/G1 cell cycle arrest thus prolonging the effectivity of the retinoids.…”

Section: Introductionmentioning

confidence: 99%

Model examinatioï¿½n of chemoprevention with retinoids in squamous cell carcinomas of the head and neck region and suitable biomarkers for chemoprevention

Fabricius

Kruse-Boitschenko²,

Schneeweiss³

et al. 2011

Int J Oncol

View full text Add to dashboard Cite

show abstract

Induction of cell cycle arrest and apoptosis by a combined treatment with 13‐cis‐retinoic acid, interferon‐α2a, and α‐tocopherol in squamous cell carcinoma of the head and neck

Abstract: Our data suggests that 3-drug combination biochemopreventive regimen has cooperative inhibitory effect on the growth of SCCHN cells. Both cell cycle arrest and apoptosis contribute to cell growth inhibition of this 3-drug combination therapy.

Cited by 11 publications

References 47 publications

Anticancer Effects of Astaxanthin and α-tocopherol in Esophageal Cancer Cell Lines

Anticancer Effects of Astaxanthin and α-tocopherol in Esophageal Cancer Cell Lines

Apoptosis-inducing activity and tumor-specificity of antitumor agents against oral squamous cell carcinoma

Model examinatioï¿½n of chemoprevention with retinoids in squamous cell carcinomas of the head and neck region and suitable biomarkers for chemoprevention

Contact Info

Product

Resources

About