Induction of caspase-dependent apoptosis in melanoma cells by the synthetic compound (E)-1-(3,4-dihydroxyphenethyl)-3-styrylurea

CopA3 peptide from Copris tripartitus induces apoptosis in human leukemia cells via a caspase-independent pathway

“…2A, CopA3 significantly induced DNA fragmentation (white spots, TUNEL) in AML, Jurkat, and U937 cells, but not in non-leukemia HeLa http://bmbreports.org cells. Propidium iodide (PI) was used for the counterstain for all nuclei (10). In agreement with results in Fig.…”

A phenolic acid phenethyl urea derivative protects against irradiation-induced osteoblast damage by modulating intracellular redoxstate

“…We preliminary found that these compounds exert antioxidant potential. Some of the PAPU compounds inhibited inflammatory responses and induced apoptosis of cancer cells [Kim et al, ; Hwang et al, ; Yu et al, ]. Our recent study also highlighted the possibility that PAPU compounds are capable of inhibiting irradiation‐mediated damage in osteoblasts [Kim et al, ].…”

“…Considering that the antioxidant potential of phenolic acids is closely correlated with various biological, pharmacological, and medicinal abilities, our efforts have focused on the development of phenolic acid derivatives with stronger antioxidant activities than their corresponding phenolic acids. We previously synthesized phenolic acid phenethyl ureas (PAPU) containing one aromatic hydroxyl group from phenolic acids by a Curtius rearrangement [Kim et al, ]. The PAPU compounds synthesized were: ( E )‐1‐(3,4‐dihydroxyphenethyl)‐3‐styrylurea (DPS‐U), ( E )‐1‐(3,4‐dihydroxystyryl)‐3‐phenethylurea (DSP‐U), ( E )‐1‐(3,4‐dihydroxystyryl)‐3‐(4‐hydroxyphenethyl) urea (DSHP‐U), ( E )‐1‐(3,4‐dihydrophenethyl)‐(3,4‐dihydroxystyryl) urea (DPDS‐U), ( E )‐1‐(4‐methoxyphenethyl)‐3‐(4‐methoxystyryl) urea (MPMS‐U), and ( E )‐1‐(3,4‐dihydroxyphenethyl)‐3‐(4‐hydroxystyryl) urea (DPHS‐U) (Fig.…”

A phenolic acid phenethyl urea compound inhibits lipopolysaccharide-induced production of nitric oxide and pro-inflammatory cytokines in cell culture

“…Many investigators have, therefore, focused either on identifying antiinflammatory agents from natural resources [6][7][8][9] or on developing synthetic anti-inflammatory compounds [10,11]. We previously used the Curtius rearrangement to synthesize various phenolic acid phenethyl ureas (PAPUs) from phenolic acids and found that these PAPU compounds have greater potential as anti-oxidants and anticancer agents than the original phenolic acids such as caffeic-, ferulic-, and p-coumaric acids [12,13]. Based on the considerable body of evidence that the anti-oxidant properties of phenolic compounds are correlated with their anti-inflammatory activities [14,15], we postulated that PAPU compounds can inhibit the endotoxindependent activation of macrophages.…”