Induction of caspase-2 gene expression in carboxyl-functionalized carbon nanotube-treated human T-cell leukemia (Jurkat) cell line

Lotfıpanah, Shirin; Zeinali, Majid; Yaghmaei, Parichehreh

doi:10.1080/01480545.2019.1609025

Cited by 5 publications

(5 citation statements)

References 33 publications

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“…However, the treatments 0.1 and 1 μg ml −1 did not affect the mitochondrial activity of human spermatozoa [27] and concentrations above 250 μg ml −1 did not decrease the mitochondrial activity of mouse lymphoma cells [68]. Human immortalized T lymphocytes showed no reduction in mitochondrial activity when exposed to 100 μg ml −1 of MWCNT-COOH [28]. Therefore, the cellular response to MWCNT-COOHs is specific for each cell type and the exposure conditions.…”

Section: Dls and Zp Evaluationmentioning

confidence: 89%

“…Data from the literature report induction of cytotoxicity by carbon nanotubes via a decrease in mitochondrial activity in different cell types [26][27][28]. Previous data revealed that MWCNT-COOH reduced the mitochondrial activity of human lung bronchial cells at concentrations of 20, 40 and 100 μg ml −1 [26].…”

Section: Dls and Zp Evaluationmentioning

confidence: 99%

“…To get insights into how MWCNT-COOHs behave in an aqueous medium and its net charge, DLS and ZP analysis of suspensions containing MWCNT-COOHs at 0, 0.1, 1, 10, 50, 100 μg ml −1 were determined on a Malvern 3000 Zetasizer NanoZS (Malvern Instruments, UK). The chosen NM concentrations are close to a realistic exposure (up to 100 μg ml −1 ) and have been used in previous works [25][26][27][28][29]. Furthermore, all concentrations of MWCNT-COOHs were freshly prepared in three types of aqueous medium: deionized water (pH 7.1), DMEM-F12 (pH 6.9-7.1), and DMEM-F12 supplemented with FBS (10% v/v) (pH 6.9-7.1).…”

Section: Dynamic Light Scattering and Zp Evaluationmentioning

confidence: 99%

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Cytocompatibility of carboxylated multi-wall carbon nanotubes in stem cells from human exfoliated deciduous teeth

Oliveira¹,

Fayer²,

Zanette³

et al. 2021

Nanotechnology

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Carboxylated multi-wall carbon nanotube (MWCNT-COOH) presents unique properties due to nanoscale dimensions and permits a broad range of applications in different fields, such as bone tissue engineering and regenerative medicine. However, the cytocompatibility of MWCNT-COOH with human stem cells is poorly understood. Thus, studies elucidating how MWCNT-COOH affects human stem cell viability are essential to a safer application of nanotechnologies. Using stem cells from the human exfoliated deciduous teeth model, we have evaluated the effects of MWCNT-COOH on cell viability, oxidative cell stress, and DNA integrity. Results demonstrated that despite the decreased metabolism of mitochondria, MWCNT-COOH had no toxicity against stem cells. Cells maintained viability after MWCNT-COOH exposure. MWCNT-COOH did not alter the superoxide dismutase activity and did not cause genotoxic effects. The present findings are relevant to the potential application of MWCNT-COOH in the tissue engineering and regenerative medicine fields.

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Section: Dls and Zp Evaluationmentioning

confidence: 89%

Section: Dls and Zp Evaluationmentioning

confidence: 99%

Section: Dynamic Light Scattering and Zp Evaluationmentioning

confidence: 99%

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Cytocompatibility of carboxylated multi-wall carbon nanotubes in stem cells from human exfoliated deciduous teeth

Oliveira¹,

Fayer²,

Zanette³

et al. 2021

Nanotechnology

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“…The results showed a slight decrease in the cell viability of cancer cells treated with carboxyl-functionalized carbon nanotubes. The results of the molecular analysis showed that Cas2 mRNA increased in the cancer cells treated with carboxyl-functionalized carbon nanotubes [ 66 ]. The application of carbon nanotube-based nanomaterials as carriers in cancer cells is summarized in Table 8 .…”

Section: Commonly Used Nanoparticles In Cancer Diagnosismentioning

confidence: 99%

Nanotechnology in Cancer Diagnosis and Treatment

et al. 2023

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Traditional cancer diagnosis has been aided by the application of nanoparticles (NPs), which have made the process easier and faster. NPs possess exceptional properties such as a larger surface area, higher volume proportion, and better targeting capabilities. Additionally, their low toxic effect on healthy cells enhances their bioavailability and t-half by allowing them to functionally penetrate the fenestration of epithelium and tissues. These particles have attracted attention in multidisciplinary areas, making them the most promising materials in many biomedical applications, especially in the treatment and diagnosis of various diseases. Today, many drugs are presented or coated with nanoparticles for the direct targeting of tumors or diseased organs without harming normal tissues/cells. Many types of nanoparticles, such as metallic, magnetic, polymeric, metal oxide, quantum dots, graphene, fullerene, liposomes, carbon nanotubes, and dendrimers, have potential applications in cancer treatment and diagnosis. In many studies, nanoparticles have been reported to show intrinsic anticancer activity due to their antioxidant action and cause an inhibitory effect on the growth of tumors. Moreover, nanoparticles can facilitate the controlled release of drugs and increase drug release efficiency with fewer side effects. Nanomaterials such as microbubbles are used as molecular imaging agents for ultrasound imaging. This review discusses the various types of nanoparticles that are commonly used in cancer diagnosis and treatment.

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“…The results showed that the survival rate of cancer cells treated with carbon nanotubes functionalized with the carboxyl group was slightly reduced. Furthermore, the results of molecular analysis showed that Cas2 mRNA was increased in cancer cells treated with carboxyl-functionalized carbon nanotubes [21,22].…”

Section: Carbon Nanotubesmentioning

confidence: 99%

An Overview of the Application of Nanoscience in Cancer Diagnosis and Treatment

Sheikhi,

Asghari Hosori,

Yari

2023

Asian Pac J Envi & Cancer

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Cancer is one of the most common causes of death. One of the most important problems in cancer treatment is the side effects of drugs and treatments. The limiting factor in cancer treatment is the lack of selectivity of drugs against cancer cells. Today, nanotechnology has been able to help in the diagnosis and treatment of this disease because most biological processes such as the creation of cancer occur in nano dimensions, therefore, in order to reduce side effects and improve existing drugs, various drug delivery systems based on nanotechnology have been developed. Cancer researchers use the ability of nanotechnology to evaluate cells and achieve the following goals: 1- Simulating the reaction of cells with protein and nucleic acids at the molecular level, and then obtaining a proper knowledge of cell behavior. 2- Studying the structure and function of intracellular proteins and research in the field of proteomics. 3- Initial determination of cancer. This article is written based on reviews of various articles in reputable journals and books related to the use of nanotechnology in cancer treatment. The selection of sources is based on suitability to the topic, year of research, non-repetition and comprehensiveness of the content. The effective treatment of cancer with the least side effects is considered one of the challenges of medical and pharmaceutical sciences, and the introduction of nanotechnology into therapeutic fields promises the production of a new group of anti-cancer drugs that provide diagnostic and therapeutic capabilities simultaneously. These structures have a special place in cancer treatment as drug carriers and optically and thermally active substance

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Induction of caspase-2 gene expression in carboxyl-functionalized carbon nanotube-treated human T-cell leukemia (Jurkat) cell line

Cited by 5 publications

References 33 publications

Cytocompatibility of carboxylated multi-wall carbon nanotubes in stem cells from human exfoliated deciduous teeth

Cytocompatibility of carboxylated multi-wall carbon nanotubes in stem cells from human exfoliated deciduous teeth

Nanotechnology in Cancer Diagnosis and Treatment

An Overview of the Application of Nanoscience in Cancer Diagnosis and Treatment

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