Induction of cancer of the glandular stomach in rats by 20‐methylcholanthrene

Abstract

The qfect of and the combined action of ephedrine hydrochloride and 20-rnethylcholanthrene (Experiment No. 2 ) on the mucosa of the glandular stomach was studied in 2.5 rats. The application of the two chemicals was carried out by means of specially constructed containers which were inserted into the wall of the glandular stomach. Polyethylene-encased wicks led from the container, touching the gastric niucosa with their tips. The chemicals were slowly pumped by stomach acfion through the wicks 011 to the mucosa. The experiments lasted .from 14 to 20 months. In Experiment No. I (32 rats) stomach tumours developed in 5 rats, in Experiment No. 2 (21 rats), in 7 rats. Most of the tumours were adtnocarcinomas. The tumours were large and invaded the serosa of the stomach. In Experiment No. 2 jive tumours out of seven showed metastasis in various organs and tissues of the abdomen.

miR-122-IGF-1R signaling allied through the dysregulated lncRNA MALAT-1 expression in gastric carcinoma

“…The forestomach was found to be the most susceptible to the carcinogen's effect, producing cornifying squamous cell carcinomas in 17 of 27 rats. The glandular portion of the stomach was also sensitive to the carcinogenic effect of 20-MCA in different ways [4] . The earliest adenocarcinomas appeared when the carcinogen was applied to the pyloric region, but by the end of the experiment, rats with the carcinogen applied to the cardiac area had the greatest number of neoplasms.…”