Induction of calcium influx from extracellular fluid by beauvericin in human leukemia cells

Chen, Bing–Fang; Tsai, Ming-Hsien; Jow, Guey–Mei

doi:10.1016/j.bbrc.2005.11.166

Cited by 48 publications

(28 citation statements)

References 28 publications

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“…1a). These molecules possess a wide range of biological activities, including antimicrobial, insecticidal, anthelmintic, herbicidal, anti-haptotactic, anti-cholesterol and anticancer activities345678. 1 – 9 are cyclic oligomers of monomer synthesized from a hydroxycarboxylic acid and an N -methylated amino acid.…”

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confidence: 99%

Decoding and reprogramming fungal iterative nonribosomal peptide synthetases

Zhang

et al. 2017

Nat Commun

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Nonribosomal peptide synthetases (NRPSs) assemble a large group of structurally and functionally diverse natural products. While the iterative catalytic mechanism of bacterial NRPSs is known, it remains unclear how fungal NRPSs create products of desired length. Here we show that fungal iterative NRPSs adopt an alternate incorporation strategy. Beauvericin and bassianolide synthetases have the same C1-A1-T1-C2-A2-MT-T2a-T2b-C3 domain organization. During catalysis, C3 and C2 take turns to incorporate the two biosynthetic precursors into the growing depsipeptide chain that swings between T1 and T2a/T2b with C3 cyclizing the chain when it reaches the full length. We reconstruct the total biosynthesis of beauvericin in vitro by reacting C2 and C3 with two SNAC-linked precursors and present a domain swapping approach to reprogramming these enzymes for peptides with altered lengths. These findings highlight the difference between bacterial and fungal NRPS mechanisms and provide a framework for the enzymatic synthesis of non-natural nonribosomal peptides.

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confidence: 99%

Decoding and reprogramming fungal iterative nonribosomal peptide synthetases

Zhang

et al. 2017

Nat Commun

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“…This process involves the activation of proteins which are involved in programmed cell death, for example, the BCL2 family of proteins has both anti-apoptotic and pro-apoptotic members. Beauvericin has also been known to induce apoptosis in the human leukemia cell lines (CCRF-CEM) through nuclear fragmentation followed by the release of cytochrome C from mitochondrial membrane which leads to activation of caspase 3 and subsequent cellular changes in morphology [17]. Similarly the apoptotic effect of Beauvericin has also been investigated in human cell lines, HepG2 and MRC-5 to possess anticonvulsion and antirhythmic activities [37].…”

Section: Induction Of Apoptosis and Cytotoxic And Antitumor Activitymentioning

confidence: 99%

“…Recent studies have shown that other than the above biochemical and molecular processes, other molecular mechanism of beauvericin is cell apoptosis [16,17] and other molecular targets of beauvericin are antiangiogenic activity, inhibition of metastasis prostate and breast cancer [18]. Therefore, these fungal natural products represent promising leading anticancer potential.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological and Therapeutic Potential of Beauvericin: A Short Review

Sood¹,

S²,

Hu$^{³

et al. 2017

J Proteomics Bioinform

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An entomopathogenic fungus, Beauveria spp. has been known to have numerous pharmacological and therapeutic implications, especially, in terms of human health making it a suitable for ethnopharmacological use. Beauvericin is a cyclic hexadepsipeptide mycotoxin, a novel bio-metabolite derived from this fungus, exhibiting a very potent anticancer, cytotoxic activities, antiplatelet aggregation and antimicrobial activities. The current review discusses the therapeutic potential of beauvericin including pharmacological and biological activities which will certainly draw the attention of scientific community to improve the production of beauvericin for its use in medical fields.

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“…The increased interest in beauvericin (BEA) is due to its potential toxicity and synergistic effects with other fusariotoxins (Logrieco et al 1996). BEA is a specific cholesterol acyltransferase inhibitor (Tomoda et al 1992), induces apoptosis in mammalian cells , human leukemia cells (Chen et al 2006) and shows cytotoxicity of the invertebrate cell line SF-9 (Ojcius et al 1991. However, until now, phytotoxic activity of BEA has only been sporadically investigated (Paciolla et al 2004, Pavlovkin et al 2006.…”

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confidence: 99%

Impact of beauvericin on membrane properties of young initial leaves of maize with different susceptibility to Fusarium

Pavlovkin¹,

Mistríková²,

Jašková³

et al. 2012

PLANT SOIL ENVIRON

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In the present study the impact of beauvericin (BEA) on the cell membrane properties and respiration of young initial leaves of maize were studied using two maize cultivars differing in their susceptibility to Fusarium sp. BEA significantly depolarized E M of leaf parenchymal cells and this depolarization showed time and dose dependency regardless on the sensitivity of maize cultivars to Fusarium. However, the extent of BEA-induced depolarization was 2-5 times higher in sensitive cv. Pavla than in tolerant cv. Lucia. Membrane permeability and K + leakage from leaves cells treated with BEA was higher in sensitive cv. Pavla but the differences were not so considerable than the depolarization of E M . Treatment of maize young initial leaves with 40 μmol BEA significantly inhibited respiration. In accord with electrophysiological measurements inhibition of respiration was higher in sensitive cv. Pavla showing 70% inhibition already after 90 min of BEA treatment while in tolerant cv. Lucia inhibition represented only 27%. The biological activity of BEA seems to be mediated by the ability of BEA to affect membrane permeability and ion transport. This is probably the initial effect of BEA on plant cell leading to subsequent effect on other cell organelles (mitochondria) and cell metabolism.

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Induction of calcium influx from extracellular fluid by beauvericin in human leukemia cells

Cited by 48 publications

References 28 publications

Decoding and reprogramming fungal iterative nonribosomal peptide synthetases

Decoding and reprogramming fungal iterative nonribosomal peptide synthetases

Pharmacological and Therapeutic Potential of Beauvericin: A Short Review

Impact of beauvericin on membrane properties of young initial leaves of maize with different susceptibility to Fusarium

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