Induction of Bone Marrow Colony-Stimulating Activity by a Filterable Agent in Leukemic and Normal Mouse Serum

Foster, Roger S.; Metcalf, Donald; Kirchmyer, Rosemary

doi:10.1084/jem.127.5.853

Cited by 24 publications

(8 citation statements)

References 10 publications

(11 reference statements)

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“…The present results indicating a short serum half life of CSF support earlier data in which rapid changes in serum CSF levels were induced by infections (Foster et al, 1968), antigens (D. Metcalf, unpublished data) and cortisone (Metcalf, 1969). The high lability of serum CSF levels may be of value to the animal in mediating prompt changes in white cell production in response to changing demands, e.g.…”

Section: Discussionsupporting

confidence: 89%

Serum Half Life in Mice of Colony Stimulating Factor Prepared from Human Urine

Metcalf

Stanley

1971

Br J Haematol

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Summary. Partially purified preparations of the colony stimulating factor (CSF) from human urine were given as a single intravenous injection to adult C57BL mice. Assays for human CSF in the sera of these mice were performed in cultures of C57BL bone marrow cells using a discriminatory rabbit anti‐human CSF antibody preparation, incapable of blocking the action of mouse serum CSF. The half life of injected CSF varied from 1.7 to 3.7 hr (mean 2.9 hr). The injection of these human urine preparations caused a temporary elevation of mouse CSF levels in the serum of recipient mice, which prolonged the effective period of elevated CSF levels in the serum following injection.

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Section: Discussionsupporting

confidence: 89%

Serum Half Life in Mice of Colony Stimulating Factor Prepared from Human Urine

Metcalf

Stanley

1971

Br J Haematol

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“…In early culture systems, the growth of colonies depended on the presence of feeder layers such as leukemic cells, fragments of kidney or lung tissue, or leukocyteconditioned medium [9][10][11][12]. It soon became clear that these feeder layers produce specific growth factors stimulating the growth of granulocyte/macrophage colonies [12].…”

Section: Introductionmentioning

confidence: 99%

Diagnostische und prognostische Bedeutung von koloniebildenden hämatopoetischen Vorläuferzellen in myeloischen Systemerkrankungen

Öhler

Geißler

Hinterberger

2003

Wien Klin Wochenschr

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Hematopoietic progenitor cells are capable of forming colonies of mature blood cells in semisolid media in response to specific growth factors. Colony assays have been extensively used for many years to study normal and malignant hematopoiesis in vitro. In fact, these assays have provided an excellent research tool for investigating growth and differentiation of progenitor cells in response to positive and negative regulators of hematopoiesis. However, apart from their role in basic research, colony assays are also widely used in routine clinical practice in the diagnosis of various hematologic disorders, such as aplastic anemia, myelodysplastic syndromes and myeloproliferative disorders. This review summarizes our current knowledge on the diagnostic value and prognostic significance of the growth of progenitor cells in peripheral blood and bone marrow in patients with myeloid malignancies.

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“…If monocytes and macrophages are indeed an important source of CSF, it is possible that their capacity to bind antibody on their cell surface in some way prevents a response being triggered by the antigen molecules. A similar, but slower, rise in serum and urine CSF levels follows the onset of viral and bacterial infections (Metcalf and Wahren, 1968;Foster, Metcalf and Kirchmyer, 1968;. This CSF response is followed by proliferation of granulocytic and macrophage (C-M) cells in an early response which precedes the subsequent proliferation of lymphocytes and antibody-forming cells (McNeill, 1970;Metcalf, 1971d).…”

mentioning

confidence: 98%