Induction of auto-immune syndromes by penicillamine therapy in rheumatoid arthritis and other diseases

Jaffe, Israeli A.

doi:10.1007/bf01857095

Cited by 39 publications

(10 citation statements)

References 75 publications

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“…In 1981, cases of autoimmune diseases induced by dpenicillamine used to treat rheumatoid arthritis, WD, or cystinuria were described (Jaffe 1981). After the discontinuation of d-penicillamine treatment, the symptoms regressed in most of the patients.…”

Section: Introductionmentioning

confidence: 98%

Concomitant immune‐related events in Wilson disease: implications for monitoring chelator therapy

Seeßle

Gotthardt

Schafer

et al. 2015

J of Inher Metab Disea

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Under long-term d-penicillamine therapy a minority of patients developed immune-mediated disease. Elevations in antinuclear antibodies were found frequently, but no correlations were evident between increases in antinuclear antibodies and the development of immune-mediated diseases or medical regimes. Thus, the value of antinuclear antibodies for monitoring adverse events under chelator therapy seems to be limited.

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Section: Introductionmentioning

confidence: 98%

Concomitant immune‐related events in Wilson disease: implications for monitoring chelator therapy

Seeßle

Gotthardt

Schafer

et al. 2015

J of Inher Metab Disea

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“…D-пеницилламин, широко использовавшийся в тера-пии ревматоидного артрита, цистинурии, болезни Вильсо-на, первичного билиарного цирроза и ССД, ассоциируется с разнообразными иммунологическими феноменами: от об-разования антител до развития аутоиммунных заболева-ний -СКВ, аутоиммунного тиреоидита, неакантолитиче-ской пузырчатки (пемфигоид), синдрома Гийена-Барре, полимиозита и васкулитов [85][86][87]. Нередко встречается и поражение почек, индуцированное приемом D-пеницилла-мина.…”

Section: D-пеницилламин-ассоциированная нефропатияunclassified

Current Views on the Heterogeneity of Renal Involvements in Patients With Systemic Sclerosis

Гордеев¹,

Захарова²,

Мутовина³

et al. 2015

rsp

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“…However, its clinical use has been somewhat limited because of the occurrence of ADRs manifested by a broad range of autoimmune syndromes including lupuslike syndrome, pemphigus, myasthenia gravis, agranulocytosis, and rash [148][149][150]. In guinea pigs, chronic administration of d-penicillamine elicited electrophysiologic, serological, and histopathologic changes resembling experimental allergic myasthenia gravis and allergic myositis [147].…”

Section: D-penicillamine-induced Autoimmunitymentioning

confidence: 99%

Idiosyncratic Drug Reactions

Wojcinski

Uetrecht

2012

Encyclopedia of Drug Metabolism and Interactions

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Idiosyncratic drug reactions (IDRs) are adverse drug reactions that are not related to the known pharmacological properties of the drug occur in only a small percentage of the population and do not show any apparent dose–response relationship. The unpredictable nature of IDRs together with the often serious adverse effects encountered pose a major health concern in the development and clinical usage of pharmaceuticals. The mechanism of IDRs is not clearly understood, and although several theories have been proposed, IDRs can be generally categorized mechanistically as either immune mediated or non‐immune‐mediated. There is circumstantial evidence that suggests that most idiosyncratic reactions are hypersensitivity reactions initiated by the formation of chemically reactive metabolites that bind to proteins and induce an immune‐mediated response. Investigations in animal models have had limited success owing to the unpredictability of IDRs in animals, which is similar to the situation in humans. However, IDRs in animals do share some similar characteristics and mechanisms observed in humans supporting the need for further study of animal models.

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Induction of auto-immune syndromes by penicillamine therapy in rheumatoid arthritis and other diseases

Cited by 39 publications

References 75 publications

Concomitant immune‐related events in Wilson disease: implications for monitoring chelator therapy

Concomitant immune‐related events in Wilson disease: implications for monitoring chelator therapy

Current Views on the Heterogeneity of Renal Involvements in Patients With Systemic Sclerosis

Idiosyncratic Drug Reactions

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