Induction of arthritis in rats by soluble peptidoglycan‐polysaccharide complexes produced by human intestinal flora

Kool, J.; Embden, J. G. H. Ruseler-Van; Lieshout, L. M. C. Van; Visser, E; Gerrits-Boeye, M Y; Berg, W. B. Van Den; Hazenberg, M. P.

doi:10.1002/art.1780341222

Cited by 15 publications

(2 citation statements)

References 24 publications

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“…PGN-PS complexes were also isolated successfully from human feces and ileostomy fluids. The arthritogenic properties of PGN-PS complexes were further proven by the adjuvant-induced arthritis model 76 . Bacterial PGNs were present in some immune cells, including macrophages and dendritic cells, in the synovia of patients with OA.…”

Section: Components From Gut Microbes and Microbe-associated Lipid Mementioning

confidence: 99%

Gut microbiota and obesity-associated osteoarthritis

Liu

Ding

Wang

et al. 2019

Osteoarthritis and Cartilage

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Obesity is a well-known primary risk factor for osteoarthritis (OA). In recent decades, the biomechanicsbased theoretical paradigm for the pathogenesis of obesity-associated OA has been gradually but fundamentally modified. This modification is a result of accumulating evidence that biological factors also contribute to the etiology of the disease. The gut microbiota is a complicated ecosystem that profoundly influences the health of the host and can be modulated by the combined effects of environmental stimuli and genetic factors. Recently, enteric dysbacteriosis has been identified as a causal factor in the initiation and propagation of obesity-associated OA in animal models. Gut microbes and their components, microbe-associated lipid metabolites, and OA interact at both systemic and local levels through mechanisms that involve interplay with the innate immune system. However, the demonstration of causality in humans will require further studies. Nonetheless, probiotics, prebiotics, dietary habits and exercise, which aid the restoration of a healthy microbial community, are potential therapeutic approaches in the treatment of obesity-associated OA.

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Section: Components From Gut Microbes and Microbe-associated Lipid Mementioning

confidence: 99%

Gut microbiota and obesity-associated osteoarthritis

Liu

Ding

Wang

et al. 2019

Osteoarthritis and Cartilage

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“…Several studies have indicated that bacterial PGN can stimulate intra-articular synovial fibroblasts and induce the expression of matrix metalloproteinases (MMPs) and pro-inflammatory cytokines by activating the outer membrane protein TLR2 on synovial fibroblasts ( Kyburz et al., 2003 ) ( Figure 3 , I ). Moreover, peptidoglycan-polysaccharide (PGN-PS) complexes have been detected in synovial underlay cells of OA-affected joints ( van der Heijden et al., 2000 ) and confirmed the arthrogenic properties in adjuvant-induced arthritis model ( Kool et al., 1991 ). Clarke et al.…”

Section: Gut Microbiota Is Involved In the Development Of Oa Through ...mentioning

confidence: 60%

Association Between Gut Microbiota and Osteoarthritis: A Review of Evidence for Potential Mechanisms and Therapeutics

Wei

2022

Front. Cell. Infect. Microbiol.

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Osteoarthritis (OA) is a multifactorial joint disease characterized by degeneration of articular cartilage, which leads to joints pain, disability and reduced quality of life in patients with OA. Interpreting the potential mechanisms underlying OA pathogenesis is crucial to the development of new disease modifying treatments. Although multiple factors contribute to the initiation and progression of OA, gut microbiota has gradually been regarded as an important pathogenic factor in the development of OA. Gut microbiota can be regarded as a multifunctional “organ”, closely related to a series of immune, metabolic and neurological functions. This review summarized research evidences supporting the correlation between gut microbiota and OA, and interpreted the potential mechanisms underlying the correlation from four aspects: immune system, metabolism, gut-brain axis and gut microbiota modulation. Future research should focus on whether there are specific gut microbiota composition or even specific pathogens and the corresponding signaling pathways that contribute to the initiation and progression of OA, and validate the potential of targeting gut microbiota for the treatment of patients with OA.

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