Induction of APS after TTd Hyper-Immunization has a Different Outcome in BALB/c and C57BL/6 Mice

Živković, Irena; Stojanović, Marijana; Petrušić, Vladimir; Inić-Kanada, Aleksandra; Dimitrijević, Ljiljana

doi:10.1111/j.1600-0897.2010.00922.x

Cited by 22 publications

(11 citation statements)

References 41 publications

(49 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In accordance with these results are our findings that TTd hyper-immunization does not lead to fetal resorption or thrombocytopenia in C57BL/6 mice. 20 The influence of applied TTd-hyper-immunization protocol on changes within aPL Abs pool was examined by three ELISA-based systems utilizing CL (alone or complexed with human b 2 GPI) or human b 2 GPI alone as antigens.…”

Section: Discussionmentioning

confidence: 99%

Induction of decreased fecundity by tetanus toxoid hyper-immunization in C57BL/6 mice depends on the applied adjuvant

et al. 2011

View full text Add to dashboard Cite

It has already been shown that tetanus toxoid (TTd) hyper-immunization is a suitable experimental method for creating the animal model of antiphospholipid syndrome (APS) in BALB/c mice. The severity of APS pathology in BALB/c mice mainly correlates to the affinity of anti-β(2) glycoprotein I (β(2)GPI) antibodies. In this study we have investigated reproductive pathology induced in C57BL/6 mice by TTd hyper-immunization using a combination of different pretreatments (complete Freund's adjuvant or glycerol) and adjuvants (alhydrogel or glycerol). A decrease in fecundity was recorded in only C57BL/6 mice immunized with alhydrogel adjuvant, irrespective of the kind of applied pretreatment; it was associated with an increase in abundance of low affinity anti-β(2)GPI IgG antibodies and Th1 prevalence.

show abstract

Section: Discussionmentioning

confidence: 99%

Induction of decreased fecundity by tetanus toxoid hyper-immunization in C57BL/6 mice depends on the applied adjuvant

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Interestingly, vaccines such as tetanus toxoid and seasonal influenza, were found to be associated with the production of antiphospholipid antibodies in both human and animal models. 84,85 Induction of APS was possible in two non-prone mouse strain (BALBc and C57BL/6) mice that were hyperimmunized with tetanus toxoid boosted with aluminum hydroxide and complete Freud’s adjuvants (CFA) that are commonly used in other vaccines. 84,85 In these animal models, APS was associated with the development of prolonged coagulation time, thrombocytopenia and fetal loss.…”

Section: Asia Syndrome and Apsmentioning

confidence: 99%

Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld’s syndrome) – An update

Watad

Quaresma

Brown

et al. 2017

Lupus

128

View full text Add to dashboard Cite

Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) has been widely described in many studies conducted thus far. The syndrome incorporates five immune-mediated conditions, all associated with previous exposure to various agents such as vaccines, silicone implants and several others. The emergence of ASIA syndrome is associated with individual genetic predisposition, for instance those carrying HLA-DRB1*01 or HLA-DRB4 and results from exposure to external or endogenous factors triggering autoimmunity. Such factors have been demonstrated as able to induce autoimmunity in both animal models and humans via a variety of proposed mechanisms. In recent years, physicians have become more aware of the existence of ASIA syndrome and the relationship between adjuvants exposure and autoimmunity and more cases are being reported. Accordingly, we have created a registry that includes at present more than 300 ASIA syndrome cases that have been reported by different physicians worldwide, describing various autoimmune conditions induced by diverse adjuvants. In this review, we have summarized the updated literature on ASIA syndrome and the knowledge accumulated since 2013 in order to elucidate the association between the exposure to various adjuvant agents and its possible clinical manifestations. Furthermore, we especially referred to the relationship between ASIA syndrome and systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS).

show abstract

“…Analyses of specific IgG subclass contributions to the entirety of the anti-ganglioside IgG pools showed that, for all experimental groups, a significant moiety of these contributing Abs belonged to subclasses IgG1 and IgG2c. 38 Anti-2 GPI antibodies in C57BL/6 and BALB/c mice Anti-b 2 GPI Abs can exert both beneficial (playing a homeostatic role) and deleterious effects, depending on their concentration, isotypic characteristics, affinity and fine epitope specificity. 46 We have already reported on the rise in the level of low-affinity anti-b 2 GPI Abs, and the Th2 prevalence dependent on Al-induced mechanisms, as well as decrease in fecundity in TTd hyperimmunized C57BL/6 mice.…”

Section: Idiotypic Network and Natural Antibodiesmentioning

confidence: 99%

Vaccine model of antiphospholipid syndrome induced by tetanus vaccine

Dimitrijević

Živković

Stojanović

et al. 2012

Lupus

View full text Add to dashboard Cite

Successful induction of antiphospholipid syndrome (APS) in two different non-autoimmune prone mouse strains, BALB/c and C57BL/6, was achieved by tetanus toxoid (TTd) hyperimmunization using different adjuvants (glycerol or aluminium hydroxide), and different adjuvant pretreatments (glycerol or Complete Freund's Adjuvant (CFA)). APS had different manifestations of reproductive pathology in BALB/c and C57BL/6 mice: fetal resorption (as a consequence of extreme T-cell activation obtained in the course of pretreatment), and lowering of fecundity (as a consequence of polyclonal B-cell stimulation), respectively. In BALB/c mice fetal resorption coincided with glycerol and CFA pretreatments, while in C57BL/6 mice lowering of fecundity was most obvious in CFA-pretreated mice immunized with TTd in aluminium hydroxide. Both molecular mimicry and polyclonal B-cell activation occur in APS induction, with molecular mimicry effects being dominant in BALB/c mice, and polyclonal cell activation being dominant in C57BL/6 mice. Confirmation of molecular mimicry effects, which in the condition of T-cell stimulation generated fetal resorptions in the BALB/c strain, was achieved by passive infusion of monoclonal antibody (MoAb) T-26 specific for TTd and anti-β(2)-glycoprotein I obtained after TTd hyperimunization. High polyclonal B-cell activation in C57BL/6 mice prevented fetal resorption but induced fecundity lowering, as was the case in passive administration of MoAb T-26 in this mouse strain. Passive infusion of anti-idiotypic MoAb Y7 into C57BL/6 mice induced fetal resorptions and confirmed the above suggestion on the protective role of polyclonal B-cell stimulation in fetal resorptions.

show abstract

Induction of APS after TTd Hyper-Immunization has a Different Outcome in BALB/c and C57BL/6 Mice

Abstract: We conclude that TTd immunization and i.v. application of monoclonal antibody 26 induced the same reproductive pathology and that the type of pathology is strain dependent.

Cited by 22 publications

References 41 publications

Induction of decreased fecundity by tetanus toxoid hyper-immunization in C57BL/6 mice depends on the applied adjuvant

Induction of decreased fecundity by tetanus toxoid hyper-immunization in C57BL/6 mice depends on the applied adjuvant

Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld’s syndrome) – An update

Vaccine model of antiphospholipid syndrome induced by tetanus vaccine

Contact Info

Product

Resources

About