Induction of Apoptosis in Bacillus Calmette–Guérin-Activated T Cells by Transforming Growth Factor-β

Méndez-Samperio, Patricia; Hernández-Garay, Marisol; Garcı́a-Martı́nez, Elizabeth

doi:10.1006/cimm.2000.1662

Cited by 14 publications

(7 citation statements)

References 35 publications

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“…TGF-␤ induces apoptosis in activated T cells (44,45). Consistent with these data, in a previous study, we showed that TGF-␤ induced apoptosis in CD4 ϩ T cells activated by allogeneic DCs (46).…”

Section: Tgf-␤-induced Apoptosis Is Reduced In Bcl-2-transduced Hbv-ssupporting

confidence: 89%

Selective Modification of Antigen-Specific CD4+ T Cells by Retroviral-Mediated Gene Transfer and in Vitro Sensitization with Dendritic Cells

Lin

Wang

2002

Clinical Immunology

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Section: Tgf-␤-induced Apoptosis Is Reduced In Bcl-2-transduced Hbv-ssupporting

confidence: 89%

Selective Modification of Antigen-Specific CD4+ T Cells by Retroviral-Mediated Gene Transfer and in Vitro Sensitization with Dendritic Cells

Lin

Wang

2002

Clinical Immunology

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“…Thus, TGF‐β could also participate in the development of fibrosis during the healing ulcerative stage, where numerous TGF‐β immunostained macrophages have been reported in human lesions [15], as we observed in the subcutaneous tissue from mice infected with the strain from Benin. TGF‐β also increases apoptosis of T cells activated by mycobacterial antigens [24,25]. Therefore, it is possible that besides mycolactone, TGF‐β could participate in producing the extensive apoptosis exhibited by the inflammatory cells in ulcerative lesions, attributed previously exclusively to mycolactone.…”

Section: Discussionmentioning

confidence: 99%

Differences in virulence and immune response induced in a murine model by isolates ofMycobacterium ulceransfrom different geographic areas

Hurtado-Ortiz¹,

León²,

Estévez³

et al. 2009

Clinical and Experimental Immunology

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SummaryBuruli ulcer (BU) is the third most common mycobacterial disease in immunocompetent hosts. BU is caused by Mycobacterium ulcerans, which produces skin ulcers and necrosis at the site of infection. The principal virulence factor of M. ulcerans is a polyketide-derived macrolide named mycolactone, which has cytotoxic and immunosuppresive activities. We determined the severity of inflammation, histopathology and bacillary loads in the subcutaneous footpad tissue of BALB/c mice infected with 11 different M. ulcerans isolates from diverse geographical areas. Strains from Africa (Benin, Ghana, Ivory Coast) induced the highest inflammation, necrosis and bacillary loads, whereas the strains collected from Australia, Asia (Japan, Malaysia, New Guinea), Europe (France) and America (Mexico) induced mild inflammation. Subsequently, animals were infected with the strain that exhibited the highest (Benin) or lowest (Mexico) level of virulence in order to analyse the local immune response generated. The Mexican strain, which does not produce mycolactone, induced a predominantly T helper type 1 (Th1) cytokine profile with constant high expression of the anti-microbial peptides beta defensins 3 and 4, in co-existence with low expression of the anti-inflammatory cytokines interleukin (IL)-10, IL-4 and transforming growth factor (TGF)-b. The highly virulent strain from Benin which produces mycolactone A/B induced the opposite pattern. Thus, different local immune responses were found depending on the infecting M. ulcerans strain.

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“…The inhibitory side to TGF‐β 1 can help to explain this. Following an inflammatory response, TGF‐β 1 also plays a part in down‐regulating the inflammatory process by inhibiting the functions of activated cells and even promoting apoptosis [25,26]. TGF‐β inhibits proliferation and cytokine production by naïve T cells and both Th1 and Th2 T cell clones, and appears to be responsible for part of the inhibitory effect of CTLA‐4 T cell signalling [27].…”

Section: Tgf‐bβ1 and The Immune Systemmentioning

confidence: 99%

Transforming growth factor‐bβ₁: its anti‐inflammatory and pro‐fibrotic effects

Ling¹,

Robinson²

2002

Clin Experimental Allergy

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Induction of Apoptosis in Bacillus Calmette–Guérin-Activated T Cells by Transforming Growth Factor-β

Cited by 14 publications

References 35 publications

Selective Modification of Antigen-Specific CD4+ T Cells by Retroviral-Mediated Gene Transfer and in Vitro Sensitization with Dendritic Cells

Selective Modification of Antigen-Specific CD4+ T Cells by Retroviral-Mediated Gene Transfer and in Vitro Sensitization with Dendritic Cells

Differences in virulence and immune response induced in a murine model by isolates ofMycobacterium ulceransfrom different geographic areas

Transforming growth factor‐bβ₁: its anti‐inflammatory and pro‐fibrotic effects

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Induction of Apoptosis in Bacillus Calmette–Guérin-Activated T Cells by Transforming Growth Factor-β

Cited by 14 publications

References 35 publications

Selective Modification of Antigen-Specific CD4+ T Cells by Retroviral-Mediated Gene Transfer and in Vitro Sensitization with Dendritic Cells

Selective Modification of Antigen-Specific CD4+ T Cells by Retroviral-Mediated Gene Transfer and in Vitro Sensitization with Dendritic Cells

Differences in virulence and immune response induced in a murine model by isolates ofMycobacterium ulceransfrom different geographic areas

Transforming growth factor‐bβ1: its anti‐inflammatory and pro‐fibrotic effects

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Transforming growth factor‐bβ₁: its anti‐inflammatory and pro‐fibrotic effects