Induction of apoptosis by Polygonatum odoratum lectin and its molecular mechanisms in murine fibrosarcoma L929 cells

Liu, Bo; Zhang, Bo; Min, Mingwei; Bian, He-jiao; Chen, Longfei; Liu, Qian; Bao, Ji

doi:10.1016/j.bbagen.2009.04.020

Cited by 65 publications

(46 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many studies support the role of Polygonatum in the activation of apoptosis [9][10]. The lectin isolated from the P. cyrtonema demonstrated outstanding inhibition against MCF-7 cells.…”

Section: Phytochemistry Of Polygonatummentioning

confidence: 99%

Phytochemistry of Genus Polygonatum: A Review

Khan¹

2015

AJBLS

View full text Add to dashboard Cite

show abstract

“…Many studies support the role of Polygonatum in the activation of apoptosis [9][10]. The lectin isolated from the P. cyrtonema demonstrated outstanding inhibition against MCF-7 cells.…”

Section: Phytochemistry Of Polygonatummentioning

confidence: 99%

Phytochemistry of Genus Polygonatum: A Review

Khan¹

2015

AJBLS

View full text Add to dashboard Cite

show abstract

“…A lectin from Polygonatum odoratum induced apoptosis in murine fibroblast L929 cells through both death receptor and mitochondrial pathways [133]; a mannose-binding lectin from Clematis montana induced cytotoxicity to L929, Hela, MCF-7, and HepG2 cancer cells lines [134]; and a mannose-binding lectin from Sophora flavescens induced apoptosis in HeLa cells dependent of the caspase-mediated signaling [135]. Interaction studies between lectin and known anticancer drugs have also demonstrated positive effects.…”

Section: Plant Lectinsmentioning

confidence: 92%

The role of nutraceutical proteins and peptides in apoptosis, angiogenesis, and metastasis of cancer cells

Mejía

Dia

2010

Cancer Metastasis Rev

148

View full text Add to dashboard Cite

The process of carcinogenesis is complex and not easy to eliminate. It includes the initial occurrence of genetic alterations which can lead to the inactivation of tumor-suppressor genes and further accumulation of genetic alterations during tumor progression. Looking for food and food components with biological properties, collectively called nutraceuticals, that can hinder such alterations and prevent the inactivation of tumor-suppressor genes is a very promising area for cancer prevention. Proteins and peptides are one group of nutraceuticals that show potential results in preventing the different stages of cancer including initiation, promotion, and progression. In this review, we summarized current knowledge on the use of nutraceutical proteins and peptides in cancer prevention and treatment. We focused on the role of plant protease inhibitors, lactoferrin and lactoferricin, shark cartilage, plant lectins, and lunasin in the apoptosis, angiogenesis, and metastasis of cancer cells. Also included are studies on bioavailability and clinical trials conducted on these promising proteins and peptides.

show abstract

“…40) Therefore, BNIP3 decreases membrane potential on molecular lever, and thus initiating autophagy after ConA internalizing to mitochondria surface. 41) In contrast, Liu et al reported that as a member of GNA, PCL induced autophagic death via activation of mitochondrial ROS-p38-p53 pathway in A375 cells, as well as via blocking Ras-Raf and PI3K-Akt pathways in L929 cells. 42,43) The signaling pathways discussed above, revealed an complicated relationship between apoptotic and autophagic death upon PCL treatments.…”

Section: )mentioning

confidence: 99%