Induction of apoptosis by essential oil from P. missionis in skin epidermoid cancer cells

Pavithra, P; Mehta, Alka; Verma, Rama Shanker

doi:10.1016/j.phymed.2017.11.004

Cited by 27 publications

(21 citation statements)

References 43 publications

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“…The production of higher level of ROS in PmEO400CP group activates the activity of p53 protein which further disrupts the mitochondrial membrane permeabilization by down-regulating the pro-survival protein such as Bcl-2 and upregulating pro-apoptotic protein such as Bax, caspase 8, Apaf-1, caspase 9 and caspase 3 (Redza-Dutordoir and Averill-Bates, 2016[ 67 ]). This observation supports Pavithra and colleagues (2018[ 65 ]) who demonstrated that the high concentration of Pamburus missionis essential oil exerts the activity of apoptosis in A431 and HaCaT cells. This was due to the increased ROS level in the high concentration of P. missionis essential oil.…”

Section: Discussionsupporting

confidence: 88%

See 1 more Smart Citation

Polygonum minus essential oil modulates cisplatin-induced hepatotoxicity through inflammatory and apoptotic pathways

Rashid

Hussan

Hamid

et al. 2020

EXCLI Journal; 19:Doc1246; ISSN 1611-2156

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Section: Discussionsupporting

confidence: 88%

“…This was due to the increased ROS level in the high concentration of P. missionis essential oil. In addition, P. missionis essential oil also contains aldehyde and alcohols which contribute to the increase of the ROS level in the treated cells (Pavithra et al, 2018[ 65 ]).…”

Section: Discussionmentioning

confidence: 99%

Polygonum minus essential oil modulates cisplatin-induced hepatotoxicity through inflammatory and apoptotic pathways

Rashid

Hussan

Hamid

et al. 2020

EXCLI Journal; 19:Doc1246; ISSN 1611-2156

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“…The extraction of O. gratissimum EOs and the methanolic extract was performed as defined by Grbic-Ljaljevic et al and Pavithra et al, respectively, with little modification. 23,24 For EO extraction, 100 g of the pulverised leaves were subjected to hydrodistillation with H 2 O (800 mL) for 4 h in a Clevenger apparatus. Anhydrous sodium sulphate was used to remove excess water from the crude EO.…”

Section: Extraction Of O Gratissimum Eos and Methanolic Extractmentioning

confidence: 99%

<p>Chitosan And N, N, N-Trimethyl Chitosan Nanoparticle Encapsulation Of <em>Ocimum Gratissimum</em> Essential Oil: Optimised Synthesis, In Vitro Release And Bioactivity</p>

Onyebuchi¹,

Kavaz²

2019

IJN

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Background: The encapsulation of plant essential oils (EOs) with polymeric materials (e.g. chitosan (CS) and N, N, N-trimethyl chitosan (TMC)) and the further reduction of the polymers into their nano sizes are gaining research interest in nanotechnology due to potential applications in medical drug delivery systems as well as the food and pharmaceutical industry. The present study reports a novel approach for the synthesis of Ocimum gratissimum essential oil (OGEO)-loaded CS and TMC nanoparticles with distinct bioactive and physiochemical properties. Methods: The OGEO-loaded CS and TMC nanoparticles were characterised using various microscopic and spectroscopic techniques. The bioactive compounds in Ocimum gratissimum methanolic extract (OG-MeOH) and EOs was evinced with gas chromatography-mass spectrometry (GC-MS). Total phenolic content (TPC) of OGEO and OG-MeOH was determined using the Folin-Ciocalteu method. The in vitro drug release kinetic pattern was ascertained by membrane dialysis, while antioxidant activity was determined by the 2,2-diphenyl-1picrylhydrozyl (DPPH) free radical scavenging method. The disc diffusion method was used for antibacterial activity evaluation, while MTT and a trypan blue dye exclusion assay were used to assess cytotoxic activity on MDA-MB-231 breast cancer cells. Results: GC-MS analysis revealed components that have not been previously reported for Ocimum gratissimum. The maximum OGEO cumulative drug release percentage in vitro was observed at pH 3 for both OGEO-loaded chitosan nanoparticles (OGEO-CSNPs) and OGEOloaded N, N, N-trimethyl chitosan nanoparticles (OGEO-TMCNPs). The antioxidant activity of OGEO-CSNPs and OGEO-TMCNPs never reached a steady state after 75 h. OGEO-TMCNPs exhibited antibacterial activity at a lower concentration for both Gram-negative and Gram-positive food pathogens. In vitro cytotoxicity revealed the increased toxicity of OGEO-TMCNPs on MDA-MB-231 breast cancer cell lines. Conclusion: OGEO-loaded CS and TMC nanoparticles were synthesised using a novel material optimisation approach. The synthesised nanoparticles have shown a promising application in the pharmaceutical and food industries.

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“…Numerous cancer cells break down glucose by aerobic glycolysis to obtain the energy needed for growth in a process known as the Warburg effect (35). It was next examined whether 20(S)-GRh2 also induced this effect on glycolysis in HeLa cells.…”

Section: (S)-grh2 Inhibits Mitochondrial Oxphos and Glycolysismentioning

confidence: 99%

Ginsenoside Rh2 inhibits HeLa cell energy metabolism and induces apoptosis by upregulating voltage‑dependent anion channel 1

et al. 2020

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20(S)-Ginsenoside Rh2 [20(S)-GRh2], one of the main active components of Panax ginseng, induces apoptosis in a wide range of cancer cell types. The present study found that 20(S)-GRh2 reduces mitochondrial membrane potential, decreases adenosine triphosphate generation and induces reactive oxygen species in HeLa cervical cancer cells. In addition, 20(S)-GRh2 activated mitochondrion-dependent apoptosis and inhibited both mitochondrial oxidative phosphorylation and glycolysis in HeLa cells. It was found that voltage-dependent anion channel 1 (VDAC1) expression was significantly upregulated by 20(S)-GRh2 treatment, while hexokinase 2 expression was downregulated and segregated from the mitochondria. Furthermore, 20(S)-GRh2 promoted Bax transport from the cytoplasm to the mitochondria, and knockdown of VdAc1 inhibited Bax transport and apoptosis. These results suggest that VdAc1 is a novel target of 20(S)-GRh2. The present study provides a better understanding of the mechanistic link between cervical cancer metabolism and growth control, and these results may facilitate the development of new treatments for cervical cancer.

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Induction of apoptosis by essential oil from P. missionis in skin epidermoid cancer cells

Cited by 27 publications

References 43 publications

Polygonum minus essential oil modulates cisplatin-induced hepatotoxicity through inflammatory and apoptotic pathways

Polygonum minus essential oil modulates cisplatin-induced hepatotoxicity through inflammatory and apoptotic pathways

<p>Chitosan And N, N, N-Trimethyl Chitosan Nanoparticle Encapsulation Of <em>Ocimum Gratissimum</em> Essential Oil: Optimised Synthesis, In Vitro Release And Bioactivity</p>

Ginsenoside Rh2 inhibits HeLa cell energy metabolism and induces apoptosis by upregulating voltage‑dependent anion channel 1

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