Induction of Apoptosis and Growth Arrest in Human Breast Carcinoma Cells by a Snake (<b><i>Walterinnesia aegyptia</i></b>) Venom Combined With Silica Nanoparticles: Crosstalk Between Bcl2 and Caspase 3

Al-Sadoon, Mohammed K.; Abdel-Maksoud, Mostafa A.; Rabah, Danny; Badr, Gamal

doi:10.1159/000341446

Cited by 48 publications

(53 citation statements)

References 36 publications

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“…According to recent study, snake venom extracted from Walterinessia aegyptia (WEV), alone or in combination with silica nano-particles can decrease the proliferation of human breast carcinoma cell line (MDA-MB-231). In this study, decreased expression of Bcl-2 and enhanced activation of caspase-3 has been found when breast cancer cell line was treated with WEV along with nano-particle and also showed significant reduction in actin polymerization and cytoskeletal rearrangement but it was not the case with non-cancer cell line (Al-Sadoon et al, 2012).…”

Section: Anticancer Activity Of Snake Venommentioning

confidence: 64%

Snake Venom: A Potent Anticancer Agent

Jain

Kumar²

2012

Asian Pacific Journal of Cancer Prevention

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Since cancer is one of the leading causes of death worldwide, and there is an urgent need to find better treatment. In recent years remarkable progress has been made towards the understanding of proposed hallmarks of cancer development and treatment. Treatment modalities comprise radiation therapy, surgery, chemotherapy, immunotherapy and hormonal therapy. Currently, the use of chemotherapeutics remains the predominant option for clinical control. However, one of the major problems with successful cancer therapy using chemotherapeutics is that patients often do not respond or eventually develop resistance after initial treatment. This has led to the increased use of anticancer drugs developed from natural resources. The biodiversity of venoms and toxins makes them a unique source from which novel therapeutics may be developed. In this review, the anticancer potential of snake venom is discussed. Some of the included molecules are under clinical trial and may find application for anticancer drug development in the near future.

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Section: Anticancer Activity Of Snake Venommentioning

confidence: 64%

Snake Venom: A Potent Anticancer Agent

Jain

Kumar²

2012

Asian Pacific Journal of Cancer Prevention

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“…Furthermore, silica NPs also biologically amplify the antineoplastic effects of a traditional snake venom medicine against breast and prostate cancer as well as multiple myeloma [162,178,179]. Extensive nanoscience evidence demonstrates not only biological amplification effects of nanosilica, but also bottom up self-assembly of silica-based nanostructures using biological materials as templates [180].…”

Section: Experimental Questionsmentioning

confidence: 99%

“…Some evidence suggests that including different sizes of the same source material NPs in antennas or multi-component nano-ensembles leads to better self-similar amplification of effects [138,142,143,[156][157][158][159][160], including stochastic resonance [139,142,161]. For higher potencies made traditionally in glass-contained liquids, the release and presence of nanosilica and/or nanosilicon in solution from succussions in glassware could contribute a drug-delivery vehicle and a biological [34,37,162], microelectronic and photonic amplifier [163,164].Some homeopathically-manufactured nanostructures from bacteria emit characteristic electromagnetic signals that can be detected and recorded [165]. Agitation of the solutions during manufacturing is necessary to generate such phenomena.…”

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confidence: 99%

“…Homeopathic Calcarea Phosphorica 3X combined with the plant-derived homeopathic medicine Symphytum 200C and another homeopathic medicine is used for osteosarcomas in India [20,108,109,172]. In low potency vs controls, homeopathic Symphytum 6C can also enhance bone formation around experimental titanium implants in rats [177].Furthermore, silica NPs also biologically amplify the antineoplastic effects of a traditional snake venom medicine against breast and prostate cancer as well as multiple myeloma [162,178,179]. Extensive nanoscience evidence demonstrates not only biological amplification effects of nanosilica, but also bottom up self-assembly of silica-based nanostructures using biological materials as templates [180].…”

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confidence: 99%

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Nonlinear Response Amplification Mechanisms for Low Doses of Natural Product Nanomedicines: Dynamical Interactions with the Recipient Complex Adaptive System

Bell

Sarter

Koithan

et al. 2013

J Nanomed Nanotechol

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The purpose of the present paper is (a) to outline the self-organized, complex adaptive network nature of the organism as recipient of nanomedicines; (b) to propose several nonlinear endogenous amplification processes by which pulsed low doses of traditional, homeopathically-manufactured natural product nanomedicines may stimulate a return toward healthier function; and (c) to discuss their potential relevance to novel, but safer than conventional dosing strategies for contemporary nanomedicines. Homeopathy is an over 200-year-old system of complementary and alternative medicine (CAM) that uses low doses of natural plant-, mineral-, and animal-sourced nanomedicines. Homeopathic manufacturing is "green", with mechanical grinding in lactose and agitation in ethanol-water as primary reagents. Agitation within glass containers at room temperature may also contribute nanosilica and nanosilicon as drug delivery vehicles and biological amplifiers. The medicine selection is matched to the recipient organism's systemic patterns of dysfunction and pulsed in the timing of the discrete doses. Endogenous amplification processes within the recipient organism may involve hormesis, time-dependent sensitization, and/or stochastic resonance. Effects are adaptive and systemically diffuse, i.e., causally indirect, rather than pharmacological and local, i.e., direct. All of these nonlinear response processes require interaction of the nanoparticle (NP) dose with the organism as a complex adaptive system. The pulsed NP dose serves as a low intensity salient danger signal for the organism to make network-wide adaptive changes that can lead to healing. The historically safe therapeutic approach of homeopathic nanomedicine dosing avoids risks of high, continuous doses and cumulative toxicity that contemporary nanomedicine researchers are now trying to solve while using NPs as if they were conventional bulk drugs. Integrating the insights, technical procedures, and clinical dosing approaches from modern and homeopathic nanomedicine could lead to major advances in the field for more effective and safer translational applications.NPs in homeopathic medicines [3]. NP concentrations are low, but measurable [3]. Like modern manufactured NPs [13], homeopathicallymanufactured medicines in solution also can exhibit aging effects [9,14]. These nanomedicines are delivered either in ethanolic liquids or sprayed and dried onto lactose or lactose/sucrose pellets for oral administration.Homeopathic manufacturing materials and methods are inherently "green" [15,16]. Previous papers have addressed the striking similarities between modern top-down mechanical attrition procedures for making nanoparticles (NPs) [17] and historical homeopathic medicine manufacturing methods and materials [15,[18][19][20][21]. These similarities include mechanically grinding source materials in lactose for hours and repeatedly agitating ethanol-water solutions containing the source Citation: Bell IR, Sarter B, Koithan M, Standish LJ, Banerji P, et al. (2013) Nonlinea...

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“…Similar findings have been reported in a study on growth inhibition of breast cancer cells with snake venom. 37 The phenomenon of cell cycle arrest has been used as a therapeutic tool to inhibit tumor progression in in vitro studies. 38 The mechanism for reduced DNA replication could be attributed to the "shutting down" of some cancer survival trails, including the NF-κB signaling cascade.…”

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confidence: 99%