Induction of anti-SARS-CoV-2 immune reactions in immune compromised patients

Pogodina, E. A.; Lobov, A. V.; Ivanova, Patricija; Kazey, V. I.; Шубина, И. Ж.

doi:10.17650/1726-9784-2021-20-4-18-25

Cited by 3 publications

(3 citation statements)

References 29 publications

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“…The system includes the following activities: a health school was opened at each enterprise, within the framework of which educational events were held, meetings with doctors of various specialties, schools of healthy nutrition, training of therapeutic and restorative physical education, and systematic classes on anti-stress therapy with specialized specialists [6][7][8][9][10]. In order to combat physical inactivity, we conducted field health days combining competence enhancement in terms of improving the competence of a healthy lifestyle, combining physical activity, gamification of tasks [11][12][13][14][15][16][17][18][19][20], creating a benevolent atmosphere, and a positive emotional background. These systems of measures were analyzed a year later on November 1, 2022.…”

Section: Terms Usedmentioning

confidence: 99%

"Ecology of Vital Activity as An Element of Antistress Therapy on The Example of The Organization of The Work of a Medical Center with Industrial Enterprises Under the VMI Program"

Komyagina

2022

BJSTR

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The main type of service is the conclusion of large corporate contracts on the health insurance system. Currently, on November 1, 2021, according to these agreements, there are 9,539 people in this center. As of November 1, 2021, all these persons underwent an initial medical examination, as well as an initial analysis of the frequency of requests for sick leave. These data made up the primary data set for assessing the real state of these enterprises. The analysis showed that 9.5% of the working time of employees of these industrial enterprises for the period from January to November 11 months of 2021 was lost due to sick leave.Of these, 3.5% of the sick leave is directly related to .

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Section: Terms Usedmentioning

confidence: 99%

"Ecology of Vital Activity as An Element of Antistress Therapy on The Example of The Organization of The Work of a Medical Center with Industrial Enterprises Under the VMI Program"

Komyagina

2022

BJSTR

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“…In 93.4% of seropositive individuals, the infection was asymptomatic. Markers of long-term immunity have been studied in [ 19 ]. The review [ 19 ] discusses a study that evaluated the humoral and cellular immune response to the BNT162b2 (Pfizer-BioNTech) anti-COVID-19 vaccine in patients receiving methotrexate.…”

Section: Introductionmentioning

confidence: 99%

“…Markers of long-term immunity have been studied in [ 19 ]. The review [ 19 ] discusses a study that evaluated the humoral and cellular immune response to the BNT162b2 (Pfizer-BioNTech) anti-COVID-19 vaccine in patients receiving methotrexate. The rate of antibody production was lower in patients receiving methotrexate, though the level of T cell response was similar in all the groups studied.…”

Section: Introductionmentioning

confidence: 99%

Impact of the New Coronavirus Infection on the Immune System of Children and Adolescents in the Region of the Russian Federation

Kostarev

Komyagina²,

Fayzrakhmanov

et al. 2022

IJERPH

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The emergence of COVID-19 (SARS-CoV-2) has presented public health professionals with new challenges in the diagnosis of the disease and treatment of patients. Nowadays, the epidemiology, clinical features, prevention and treatment of the disease are studied poorly due to continuous mutation of the pathogen. One of the consequences of the new coronavirus infection could be changes in the immune system of the human population. A detailed analysis of the immunological status of different racial groups under the influence of the new coronavirus infection is currently studied insufficiently, making this work of particular relevance. There is also a reluctance among some Russian residents to be vaccinated, including the population of Perm Krai, due to a lack of research on possible deviations in cellular immunity due to SARS-CoV-2 vaccination. At the start of the third wave caused by the new coronavirus infection, only 40% of the Russian population had been vaccinated, which was insufficient to acquire collective immunity. In the autumn of 2021, a QR code measure was introduced for vaccinated residents, which resulted in exceeding the necessary barrier for acquiring collective immunity. Due to the high growth and severity of the disease, we analysed the immunograms of children and adolescents, aged from 5 months to 17 years, in Perm Krai during the pandemic years 2020–2021. The patients’ immunological status results were divided into three categories. Laboratory diagnosis of the human immune system was carried out using serological and flow cytophotometric analyses. A total of 247 samples were analysed. The aim of this work was to investigate changes in the immune system of children and adolescents during the pandemic caused by the new coronavirus infection. The methodology was based on the analysis of immunograms, including biochemical studies, immune status and flow cytophotometric analysis. The immunograms were pre-sorted by IgA, IgM, IgG immunoglobulin status into four categories: absence of disease—k1 in which IgA, IgM, IgG immunoglobulin values were within the reference interval, active disease stage—k2 in which IgA, IgM immunoglobulins had gone beyond the reference interval, passive disease stage—k3 characterised by IgG and IgM immunoglobulin status, and patient recovery process—k4. In the immunograms, three immune status indicators were selected for further investigation: phagocytosis absolute value, phagocytic number and phagocytic index and five flow cytometry indices: leukocytes, lymphocytes, NK cells (CD16+CD56+), T helpers (CD3+CD4+) and CD4+/CD8+ immunoregulation index. A quantitative analysis of the deviations of these indicators from the reference intervals was performed in the three studied age groups of children and adolescents living in Perm Krai of the Russian Federation during the pandemic of 2020–2021.

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Ecology of vital activity as an element of antistress therapy on the example of the organization of the work of a medical center with industrial enterprises under the VMI program

OV¹

2022

J Addict Ther Res

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Induction of anti-SARS-CoV-2 immune reactions in immune compromised patients

Cited by 3 publications

References 29 publications

"Ecology of Vital Activity as An Element of Antistress Therapy on The Example of The Organization of The Work of a Medical Center with Industrial Enterprises Under the VMI Program"

"Ecology of Vital Activity as An Element of Antistress Therapy on The Example of The Organization of The Work of a Medical Center with Industrial Enterprises Under the VMI Program"

Impact of the New Coronavirus Infection on the Immune System of Children and Adolescents in the Region of the Russian Federation

Ecology of vital activity as an element of antistress therapy on the example of the organization of the work of a medical center with industrial enterprises under the VMI program

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