Induction of annexin-1 during TRAIL-induced apoptosis in thyroid carcinoma cells

Petrella, Antonello; Festa, Michelina; Ercolino, Simona Francesca; Zerilli, M; Stassi, Giorgio; Solito, Egle; Parente, Luca

doi:10.1038/sj.cdd.4401645

Cited by 34 publications

(31 citation statements)

References 4 publications

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“…ANXA1 plays a role in phospholipase A2 activity (Solito et al 2003), as well as mediating apoptosis (Petrella et al 2005). Therefore, it is logical that ANXA1 was dramatically up-regulated in the regressed CL in comparison with the functional CL (this study).…”

Section: Signal Transduction and Apoptosismentioning

confidence: 89%

Ovine corpus luteum proteins, with functions including oxidative stress and lipid metabolism, show complex alterations during implantation

Arianmanesh¹,

McIntosh²,

Lea³

et al. 2011

Journal of Endocrinology

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Progesterone (P 4 ) secreted by the corpus luteum (CL) is critical for in utero embryo survival and development, although CL proteins are key regulatory factors during the luteal phase. We, therefore, characterised protein expression patterns in ovine CL of pregnancy (days 12, 16 and 20) compared with those of controls, CL of oestrous cycle (days 12 and 16), using two-dimensional gel electrophoresis (2DE) gel-based proteomics. Proteins in 24 significantly altered spots were identified by tandem mass spectroscopy. At the time of embryo implantation (day 16), 77 spots were up-regulated and 101 spots were down-regulated in CL of pregnancy compared with regressed CL. Vimentin, lamin A/C (LMNA), [Mn] superoxide dismutase (SOD2), isocitrate dehydrogenase 1, annexin A1 and elongation factor Tu, mitochondrial (TUFM) altered during CL regression, whereas glutathione S-transferase A1, apolipoprotein A-1, myxovirus resistance protein 1, ornithine aminotransferase and enoyl-CoA hydratase, mitochondrial (ECHS1) tended to be altered during CL maintenance. biliverdin reductase B (BLVRB), FDXR, guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (GNB2) and cytochrome bc1 complex subunit 1, mitochondrial (UQCRC1) showed divergent expression during CL regression and maintenance. The expression of two representative proteins, SOD2 and BLVRB, by western blot increased in CL of non-pregnant ewes on day 16 compared with that on day 12. SOD2 and BLVRB were localised in the large and small luteal cells and endothelial cells of CL over peri-implantation periods. 2DE gel and mass spectrometry have been used, for the first time, to study ovine CL function. We have identified proteins involved in key pathways, including oxidative stress, steroidogenesis, signal transduction and apoptosis, which have not previously been associated with changes occurring in the CL during the peri-implantation period. These proteins are most likely involved with mechanisms allowing the CL to produce P 4 during early pregnancy.

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Section: Signal Transduction and Apoptosismentioning

confidence: 89%

Ovine corpus luteum proteins, with functions including oxidative stress and lipid metabolism, show complex alterations during implantation

Arianmanesh¹,

McIntosh²,

Lea³

et al. 2011

Journal of Endocrinology

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“…Bid, a member of the Bcl2 proapoptotic family, is cleaved to tBid by the initiator caspase-8 upon activation, myristoylated by myristoyl-CoA: protein N-myristoyltransferase before relocalization to mitochondria for the signaling of cytochrome c release (35) from the mitochondria, a characteristic of the intrinsic pathway (36,37). Previous studies have shown that ANXA1 is a proapoptotic protein that can regulate tumor necrosis factor-related apoptosis-inducing ligand-induced cell death in follicular thyroid carcinoma cells through the regulation of Bcl-2/Bcl-X Lassociated death promoter activity and translocation to the mitochondria (38). In addition, neutrophil apoptosis is induced by ANXA1 in a calcium-dependent manner and through the dephosphorylation of Bcl-2/Bcl-X L -associated death promoter (39).…”

Section: Discussionmentioning

confidence: 99%

Quantitative Proteomics Profiling of Murine Mammary Gland Cells Unravels Impact of Annexin-1 on DNA Damage Response, Cell Adhesion, and Migration

Swa

Blackstock

Lim

et al. 2012

Molecular & Cellular Proteomics

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Annexin 1 (ANXA1), the first characterized member of the annexin superfamily, is known to bind or annex to cellular membranes in a calcium-dependent manner. Besides mediating inflammation, ANXA1 has also been reported to be involved in important physiopathological implications including cell proliferation, differentiation, apoptosis, cancer, and metastasis. However, with controversies in ANXA1 expression in breast carcinomas, its role in breast cancer initiation and progression remains unclear. To elucidate how ANXA1 plays a role in breast cancer initiation, we performed stable isotope labeling of amino acids in cell culture analysis on normal mammary gland epithelial cells from ANXA1-heterozygous (ANXA1 ؉/؊ ) and ANXA1-null (ANXA1 ؊/؊ ) mice. Among over 4000 quantified proteins, we observed 214 up-regulated and 169 down-regulated with ANXA1 ؊/؊ . Bioinformatics analysis of the down-regulated proteins revealed that ANXA1 is potentially implicated in DNA damage response, whereas the analysis of up-regulated proteins showed the possible roles of ANXA1 in cell adhesion and migration pathways. These observations were supported by relevant functional assays. The assays for DNA damage response demonstrated an accumulation of more DNA damage with slower recovery on heat stress and an impaired oxidative damage response in ANXA1 ؊/؊ cells in comparison with ANXA1 ؉/؊ cells. Overexpressing Yes-associated protein 1 or Yap1, the most down-regulated protein in DNA damage response pathway cluster, rescued the proliferative response in ANXA1؊/؊ cells exposed to oxidative damage. Both migration and wound healing assays showed that ANXA1 ؉/؊ cells possess higher motility with better wound closure capability than ANXA1 ؊/؊ cells. Knocking down of ␤-parvin, the protein with the highest fold change in the cell adhesion protein cluster, indicated an increased cell migration in ANXA1 ؊/؊ cells. Altogether our quantitative proteomics study on ANXA1 suggests that ANXA1

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“…36 In addition, ANXA1 expression is strongly induced in thyroid carcinoma cells during ''tumor necrosis factor-related apoptosis inducing ligand'' (TRAIL)-induced apoptosis. 37 Preliminary experiments by us to investigate if treatment with peptide Ac2-26 (2 lM) influenced apoptosis in Hep-2 cells revealed that there was no increase in apoptotic cell number as identified by ANXA5 binding (data not shown). Another possible mechanism for the antiproliferative action of ANXA1 could be via activation of the extracellular receptor kinase (ERK) signaling cascade, as previously demonstrated in a variety of cell types.…”

Section: Discussionmentioning

confidence: 99%

Annexin 1: Differential expression in tumor and mast cells in human larynx cancer

Silistino-Souza

Rodrigues-Lisoni

Cury

et al. 2007

Intl Journal of Cancer

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Annexin 1 protein (ANXA1) expression was evaluated in tumor and mast cells in human larynx cancer and control epithelium. The effect of the exogenous ANXA1 (peptide Ac 2-26) was also examined during the cellular growth of the Hep-2 human larynx epidermoid carcinoma cell line. This peptide inhibited the proliferation of the Hep-2 cells within 144 hr. In surgical tissue specimens from 20 patients with larynx cancer, ultrastructural immunocytochemistry analysis showed in vivo down-regulation of ANXA1 expression in the tumor and increased in mast cells and Hep-2 cells treated with peptide Ac2-26. Combined in vivo and in vitro analysis demonstrated that ANXA1 plays a regulatory role in laryngeal cancer cell growth. We believe that a better understanding of the regulatory mechanisms of ANXA1 in tumor and mast cells may lead to future biological targets for the therapeutic intervention of human larynx cancer. ' 2007 Wiley-Liss, Inc.

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Induction of annexin-1 during TRAIL-induced apoptosis in thyroid carcinoma cells

Cited by 34 publications

References 4 publications

Ovine corpus luteum proteins, with functions including oxidative stress and lipid metabolism, show complex alterations during implantation

Ovine corpus luteum proteins, with functions including oxidative stress and lipid metabolism, show complex alterations during implantation

Quantitative Proteomics Profiling of Murine Mammary Gland Cells Unravels Impact of Annexin-1 on DNA Damage Response, Cell Adhesion, and Migration

Annexin 1: Differential expression in tumor and mast cells in human larynx cancer

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