Abstract:Transforming growth factor alpha (TGFa) is an important epidermal growth factor receptor (EGFR) ligand. Over-expression of both molecules in epithelial tumors has been correlated with poor prognosis and disease progression. Due to the importance of TGFa in tumorigenesis, this molecule has great potential for cancer immunotherapy. We previously designed a TGFa-based vaccine consisting of a fusion protein between human TGFa (hTGFa) and P64k protein from Neisseria meningitidis expressed in Escherichia coli. Howev… Show more
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