2000
DOI: 10.1002/1097-0169(200011)47:3<236::aid-cm6>3.0.co;2-k
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Induction of Alzheimer-specific tau epitope AT100 in apoptotic human fetal astrocytes

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Cited by 20 publications
(6 citation statements)
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“…These data are consistent with fact that Tau is hyperphosphorylated in cell models using the PP2A inhibitor, okadaic acid (Mailliot et al . 1998; Ksiezak‐Reding et al . 2000).…”
Section: Discussionmentioning
confidence: 99%
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“…These data are consistent with fact that Tau is hyperphosphorylated in cell models using the PP2A inhibitor, okadaic acid (Mailliot et al . 1998; Ksiezak‐Reding et al . 2000).…”
Section: Discussionmentioning
confidence: 99%
“…For instance, the Alzheimer‐like modification of Tau in Xenopus oocyte does not require any drug or inhibitor unlike transfected cell lines that should be treated with the phosphatases inhibitor okadaic acid (Mailliot et al . 1998; Ksiezak‐Reding et al . 2000), nocodazole or taxotere (Illenberger et al .…”
Section: Discussionmentioning
confidence: 99%
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“…These findings are in agreement with previous studies in apoptotic PC12 cells (Nuydens et al, 1997; Davis and Johnson, 1999a,b). In addition, a recent study presented evidence that tau is hyperphosphorylated at the AT100 epitope in apoptotic human fetal astrocytes (Ksiezak‐Reding et al, 2000) indicating that increased tau phosphorylation may be a generalized outcome of apoptotic cascades. Increased tau phosphorylation should result in a decreased association with microtubules.…”
Section: Discussionmentioning
confidence: 99%
“…In these cells, however, there was almost no total tau immunoreactivity, indicating that tau, as well as other proteins, was dephosphorylated and degraded at the end of the apoptotic process. Therefore, tau is hyperphosphorylated during the early stages of the apoptotic process when cytoskeletal rearrangements are occurring (Nuydens et al, 1997; Davis and Johnson, 1999a; Patrick et al, 1999; Ksiezak‐Reding et al, 2000), but in the end stages of apoptosis when the cell is in the final stages of disposing of itself, tau along with most proteins, is degraded. A dephosphorylated 17 kDa fragment of tau was also seen in the later stages of apoptosis in serum and potassium deprived cerebellar granule cells (Canu et al, 1998).…”
Section: Discussionmentioning
confidence: 99%