Induction of Ageing and Apoptosis by Sucrose in Penicillium aurantiogriseum

Abstract

This work aims to study the physiological and metabolic responses of P. aurantiogriseum to sucrose-induced stress. Comparative analyses on intra-species (within strains of P. aurantiogriseum), and interspecies (between P. aurantiogriseum and P. camembertii) were conducted to assess the effect of carbon stress on aging phenomena and toxigenesis. Our results revealed a correlation between sucrose concentration and ageing signs. At a sucrose concentration of 500 g/L, the ageing signs of P. aurantiogriseum began to fade, allowing its normal characteristics to resurface. This transformation is believed to be a response to the sucrose and the cells that cannot adapt undergo apoptosis, leaving only the normal cells to thrive. Terrestric acid production was observed during the ageing process and continued even after returning to a normal physiological state, albeit at a reduced level.