Induction of adiponectin in skeletal muscle of type 2 diabetic mice: in vivo and in vitro studies

Delaigle, Aurélie; Sènou, Maximin; Guiot, Yves; Many, Marie‐Christine; Brichard, Sonia

doi:10.1007/s00125-006-0210-y

Cited by 142 publications

(164 citation statements)

References 46 publications

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“…In this regard, there are a few possibilities as follows. First, although it has generally been thought that APN is exclusively produced in adipocytes, a recent study suggests that expression of APN is induced in other tissues under the pathological conditions, such as skeletal muscle cells in T2D50 and aortic endothelial cells in cold storage 51. Therefore, it is not surprising that expression of APN is observed in degenerating neurons.…”

Section: Apn May Promote Neurodegeneration In Ad Through Novel Mechanmentioning

confidence: 99%

Importance of adiponectin activity in the pathogenesis of Alzheimer's disease

Waragai

Ho²,

Takamatsu

et al. 2017

Ann Clin Transl Neurol

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A recent study suggested that insulin resistance may play a central role in the pathogenesis of Alzheimer's disease (AD). In this regard, it is of note that upregulation of plasma adiponectin (APN), a benign adipokine that sensitizes the insulin receptor signaling pathway and suppresses inflammation, has recently been associated with the severities of amyloid deposits and cognitive deficits in the elderly, suggesting that APN may enhance the risk of AD. These results are unanticipated because AD has been linked to type II diabetes and other metabolic disorders in which hypoadiponectinemia has been firmly established, and because APN ameliorated neuropathological features in a mouse model of neurodegeneration. Therefore, the objective of this study is to discuss the possible mechanisms underlying the biological actions of APN in the context of AD. Given that insulin receptor signaling is required for normal function of the nervous system, we predict that APN may be upregulated to compensate for compromised activity of the insulin receptor signaling pathway. However, increased APN might be sequestered by tau in the brain, leading to neurotoxic protein aggregation in AD. Alternatively, misfolding of APN may result in downregulation of the insulin/APN signal transduction network, leading to decreased neuroprotective and neurotrophic activities. Thus, it is possible that both ‘gain of function’ and ‘loss of function’ of APN may underlie synaptic dysfunction and neuronal cell death in AD. Such a unique biological mechanism underlying APN function in AD may require a novel therapeutic strategy that is distinct from previous treatment for metabolic disorders.

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Section: Apn May Promote Neurodegeneration In Ad Through Novel Mechanmentioning

confidence: 99%

Importance of adiponectin activity in the pathogenesis of Alzheimer's disease

Waragai

Ho²,

Takamatsu

et al. 2017

Ann Clin Transl Neurol

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show abstract

“…It is important to underline that skeletal muscle is an important site of adiponectin production [64][65][66]. Myotubes produce and secrete functional fAd through a PPARγ-dependent mechanism [67] and the amount of myotube-produced fAd increases in the pro-oxidant/ inflammatory microenvironment related to damage [43,64,65].…”

Section: Adiponectin As a Tissue-regenerating Hormonementioning

confidence: 99%

“…Myotubes produce and secrete functional fAd through a PPARγ-dependent mechanism [67] and the amount of myotube-produced fAd increases in the pro-oxidant/ inflammatory microenvironment related to damage [43,64,65]. A much-debated point is how and in what conditions gAd is produced, since the modalities of its production are still unclear.…”

Section: Adiponectin As a Tissue-regenerating Hormonementioning

confidence: 99%

Adiponectin as a tissue regenerating hormone: more than a metabolic function

Fiaschi

Magherini

Gamberi

et al. 2013

Cell. Mol. Life Sci.

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“…Finally, it remains to be clarified which of the mechanisms of action of spa therapy [11][12][13][14][15][16] may have determined the changes in plasma levels of leptin and, above all, adiponectin that we observed. One possible hypothesis is that local application of heat, by causing an increase in the internal temperature of the knee, may determine a change in serum adipocytokine levels, probably due to localized production thereof [5].…”

mentioning

confidence: 91%

“…Since serum levels of leptin and adiponectin are influenced by temperature [11,12], catecholamines [13], corticosteroids [14] and TNF-α and IL-1 β [15,16], we evaluated whether Spa therapy modify plasma levels of leptin and adiponectin in patients with OA treated with a cycle of a combination of daily locally-applied mud packs and bicarbonate-sulphate mineral bath water.…”

Section: Introductionmentioning

confidence: 99%

Effects of Spa therapy on serum leptin and adiponectin levels in patients with knee osteoarthritis

et al. 2010

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The aim of the present study was to assess whether spa therapy modified plasma levels of leptin and adiponectin in thirty patients with knee OA treated with a cycle of a combination of daily locally-applied mud packs and bicarbonate-sulphate mineral bath water. Leptin and adiponectin plasma levels were assessed at baseline and after two weeks, upon completion of the spa treatment period. The concentrations of leptin and adiponectin were measured by ELISA.At basal time, plasma leptin levels were significantly correlated with body mass index (BMI) and gender, but no significant correlation was found with patient age, duration of disease, radiographic severity of knee OA, VAS score or Lequesne index.There was no correlation between plasma adiponectin level and BMI, gender and age, duration of the disease, radiographic severity of knee OA, and VAS score. A significant correlation of plasma adiponectin levels was found only with the Lequesne index.At the end of the mud-bath therapy cycle, serum leptin levels showed a slight but not significant increase, while a significant decrease (p<0.05) of serum adiponectin levels was found. However, leptin and adiponectin concentrations after treatment were not correlated with other clinical parameters.In conclusion, our data show that spa therapy can modify plasma levels of the adipocytokines leptin and adiponectin, important mediators of cartilage metabolism. Whether this effect may play a potential role in OA needs further investigations.

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Induction of adiponectin in skeletal muscle of type 2 diabetic mice: in vivo and in vitro studies

Abstract: The paradoxical upregulation of adiponectin in muscle of obese and diabetic mice may result from lipotoxicity and related oxidative stress. This unexpected finding could be viewed as a local protection to counteract ectopic fat deposition and oxidative damage.

Cited by 142 publications

References 46 publications

Importance of adiponectin activity in the pathogenesis of Alzheimer's disease

Importance of adiponectin activity in the pathogenesis of Alzheimer's disease

Adiponectin as a tissue regenerating hormone: more than a metabolic function

Effects of Spa therapy on serum leptin and adiponectin levels in patients with knee osteoarthritis

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