Induction of a secretory IgA response in the murine female urogenital tract by immunization of the lungs with liposome-supplemented viral subunit antigen

deHaan, Annemarie; Kb, Renegar; Small, Parker A.; Wilschut, Jan

doi:10.1016/0264-410x(94)00062-r

Cited by 46 publications

(25 citation statements)

References 13 publications

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“…Intranasal (i.n.) immunization with a variety of antigens has induced significant increases in specific immunoglobulin A (IgA) responses at intestinal, pulmonary, and other mucosal surfaces, such as the vagina (1,4,5,11,13,24,28,29,32). In this study, we tested the potential of rNV VLPs as an i.n.…”

mentioning

confidence: 99%

Recombinant Norwalk Virus-Like Particles Administered Intranasally to Mice Induce Systemic and Mucosal (Fecal and Vaginal) Immune Responses

Guerrero

Ball²,

Krater³

et al. 2001

J Virol

109

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mentioning

confidence: 99%

Recombinant Norwalk Virus-Like Particles Administered Intranasally to Mice Induce Systemic and Mucosal (Fecal and Vaginal) Immune Responses

Guerrero

Ball²,

Krater³

et al. 2001

J Virol

109

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“…With the use of radiolabeled protein in solution, it has been shown that pentobarbital anesthesia leads to fluid accumulation in the lungs, whereas the radioactivity was largely confined to the nasal epithelium of nonanesthetized mice (29). It has likewise been demonstrated that intranasal delivery of an influenza subunit vaccine mixed with negatively charged liposomes during light ether or pentobarbital anesthesia increased the amount of fluid in the lungs (10). Presentation of antigens in this way to the upper as well as the lower airways has been referred to as total respiratory tract immunization (10,13,29).…”

mentioning

confidence: 99%

Influence of Intravenous Anesthesia on Mucosal and Systemic Antibody Responses to Nasal Vaccines

et al. 2002

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Inhalation of antigens may stimulate the immune system by way of the upper as well as the lower airways. We have shown that at least 1,000 times more live pneumococci were recovered from pulmonary tissue after being presented as drops of a liquid suspension onto the nares of anesthetized mice compared to the number of bacteria recovered from animals that were not anesthetized in the course of the challenge. Mice that were similarly immunized intranasally by inhalation of three different nonreplicating particulate vaccine formulations, i.e., a meningococcal outer membrane vesicle (OMV) vaccine, a formalin-inactivated whole-virus influenza (INV) vaccine, and the INV vaccine with OMVs as a mucosal adjuvant, during general intravenous anesthesia developed concentrations of vaccine-specific serum immunoglobulin G (IgG) antibodies that were four to nine times higher than in mice that were fully awake during immunizations. The concentrations of IgA antibodies in serum were also higher in anesthetized than in nonanesthetized mice and correlated positively with the corresponding levels of serum IgG antibodies in the anesthetized but not in the nonanesthetized mice. In saliva and feces, however, the concentrations of IgA antibodies were equally high whether or not the animals were dormant during immunizations. The results indicate that intrapulmonary antigen presentation, as a part of an intranasal immunization strategy, is of importance for systemic but not for mucosal antibody responses. A major portion of IgA antibodies in serum may thus be derived from nonmucosal sites.

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“…Stimulation of these IgA-inductive sites by antigens results in dissemination of specific IgA-producing cells to effector sites throughout the mucosal tissues (9,19,25,44), leading to the concept of a common mucosal immune system (20).…”

Section: Introduction Smentioning

confidence: 99%

“…Immunization of the respiratory tract with liposomes supplemented with influenza viral hemagglutinin, for example, stimulates an IgA response in the murine uterus (9,44). There are numerous studies correlating S-IgA production in the female reproductive tract with immunity (1,4,7,10,14-17, 21-23,25,27,36,43); however, a role for S-IgA in protection of the female reproductive tract against viral infection has not been directly demonstrated.…”

Section: Introduction Smentioning

confidence: 99%

Influenza Virus Infection of the Murine Uterus: A New Model for Antiviral Immunity in the Female Reproductive Tract

2006

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Induction of a secretory IgA response in the murine female urogenital tract by immunization of the lungs with liposome-supplemented viral subunit antigen

Cited by 46 publications

References 13 publications

Recombinant Norwalk Virus-Like Particles Administered Intranasally to Mice Induce Systemic and Mucosal (Fecal and Vaginal) Immune Responses

Recombinant Norwalk Virus-Like Particles Administered Intranasally to Mice Induce Systemic and Mucosal (Fecal and Vaginal) Immune Responses

Influence of Intravenous Anesthesia on Mucosal and Systemic Antibody Responses to Nasal Vaccines

Influenza Virus Infection of the Murine Uterus: A New Model for Antiviral Immunity in the Female Reproductive Tract

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