Induction de la chondrogen�se de r�paration

Coutelier, L; Delloye, Christian

doi:10.1007/bf00266461

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…First, the periosteum is one essential tissue taking part in natural bone repair. This highly-vascularized bilayer collagen membrane covering the bone surface has an evident and unique osteogenic potential for bone healing through endochondral ossification [6][7][8][9]. Thanks to the presence of periosteal mesenchymal stem cells (PMSCs), it contributes to transverse bone growth and bone remodeling, as well as initiating the fracture callus [6][7][8]10,11].…”

Section: Introductionmentioning

confidence: 99%

“…This highly-vascularized bilayer collagen membrane covering the bone surface has an evident and unique osteogenic potential for bone healing through endochondral ossification [6][7][8][9]. Thanks to the presence of periosteal mesenchymal stem cells (PMSCs), it contributes to transverse bone growth and bone remodeling, as well as initiating the fracture callus [6][7][8]10,11]. The mesenchymal stem cells' (MSCs) differentiation towards the osteogenic pathway is regulated by multiple orchestrated signals coming from the surrounding microenvironment, one of the critical ones being the extra-cellular matrix (ECM)-cell interaction [12].…”

Section: Introductionmentioning

confidence: 99%

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A New Osteogenic Membrane to Enhance Bone Healing: At the Crossroads between the Periosteum, the Induced Membrane, and the Diamond Concept

et al. 2023

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The lack of viability of massive bone allografts for critical-size bone defect treatment remains a challenge in orthopedic surgery. The literature has reviewed the advantages of a multi-combined treatment with the synergy of an osteoconductive extracellular matrix (ECM), osteogenic stem cells, and growth factors (GFs). Questions are still open about the need for ECM components, the influence of the decellularization process on the latter, the related potential loss of function, and the necessity of using pre-differentiated cells. In order to fill in this gap, a bone allograft surrounded by an osteogenic membrane made of a decellularized collagen matrix from human fascia lata and seeded with periosteal mesenchymal stem cells (PMSCs) was analyzed in terms of de-/recellularization, osteogenic properties, PMSC self-differentiation, and angiogenic potential. While the decellularization processes altered the ECM content differently, the main GF content was decreased in soft tissues but relatively increased in hard bone tissues. The spontaneous osteogenic differentiation was necessarily obtained through contact with a mineralized bone matrix. Trying to deepen the knowledge on the complex matrix–cell interplay could further propel these tissue engineering concepts and lead us to provide the biological elements that allow bone integration in vivo.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A New Osteogenic Membrane to Enhance Bone Healing: At the Crossroads between the Periosteum, the Induced Membrane, and the Diamond Concept

et al. 2023

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Morphological Aspects of Bone Regeneration in Cortical Bone Lengthening Using Ilizarov’s Technique

Delloye¹,

Delefortrie²,

Coutelier³

1990

Bone Circulation and Bone Necrosis

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Long‐Term Growth of a Vascularized Auricular Perichondrocutaneous Flap in Laryngotracheal Reconstruction

Hoff

Esclamado

1999

Otolaryngol.--head neck surg.

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This study addresses the potential for ongoing cartilage proliferation after repair of laryngotracheal stenosis with vascularized perichondrium. We randomly assigned 32 New Zealand white rabbits to 1 of 3 groups: group 1 (early cartilage growth, n = 10), group 2 (long-term cartilage growth after pedicle ligation, n = 11), and group 3 (long-term cartilage growth without pedicle ligation, n = 11). Bilateral auricular perichondrocutaneous flaps were elevated and transposed into full-thickness anterior tracheal wall or anterior cricothyroid membrane defects. Six weeks after elevation of the flap, animals were randomly assigned to undergo ligation of either the right or left vascular pedicle (group 2), with the contralateral auricular flap used as a matched control (group 3). Neochondrogenesis was present at 6 weeks in group 1 (0.74 +/- 0.14 mm, n = 12 ears). Cartilage thickness did not differ between groups 2 and 3 one year after ligation of the vascular pedicle: group 2 (0.48 +/- 0.24 mm, n = 18) versus group 3 (0.42 +/- 0.12 mm); P > 0.05. We conclude that in the rabbit model, chondrogenesis did not appear to be ongoing and did not result in late stenosis of the reconstructed airway. Furthermore, delayed ligation of the vascular pedicle neither inhibited nor stimulated cartilage proliferation.

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Induction de la chondrogen�se de r�paration

Cited by 3 publications

References 7 publications

A New Osteogenic Membrane to Enhance Bone Healing: At the Crossroads between the Periosteum, the Induced Membrane, and the Diamond Concept

A New Osteogenic Membrane to Enhance Bone Healing: At the Crossroads between the Periosteum, the Induced Membrane, and the Diamond Concept

Morphological Aspects of Bone Regeneration in Cortical Bone Lengthening Using Ilizarov’s Technique

Long‐Term Growth of a Vascularized Auricular Perichondrocutaneous Flap in Laryngotracheal Reconstruction

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