Induction chemotherapy followed by radiochemotherapy for locally advanced head and neck cancer as an individual treatment approach—Feasibility, safety and retrospective survival analysis in twenty‐three patients

Busch, Chia‐Jung; Girke, J.; Tribius, Silke; Bußmann, Lara; Knecht, Rainald; Schafhausen, Philippe; Lőrincz, Balázs B.; Münscher, Adrian

doi:10.1111/coa.12890

Cited by 1 publication

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“…Total regression of the HNC after IC‐CCR is not a rare event, and the reported rate for such a result has been >40% . Despite the favorable response to sequential chemoradiotherapy, the patients studied succumbed to local/regional recurrent tumor or distant metastases.…”

Section: Discussionmentioning

confidence: 98%

Outcome in radiographic complete regression of unresectable head and neck cancer with carotid artery encasement from induction chemotherapy followed by concurrent chemoradiotherapy: Case reports

Ampil

Takalkar

Sangster

et al. 2019

Precision Radiation Oncology

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Little is known about the effects of non‐operative treatment for unresectable head and neck cancer with carotid artery encasement. While induction chemotherapy followed by concurrent chemoradiotherapy/sequential chemoradiotherapy is usually recommended for this disease entity, conclusive evidence regarding the benefit achieved from such therapeutic intervention remains sparse. The authors describe two cases of head and neck cancer with carotid artery encasement managed by induction chemotherapy followed by concurrent chemoradiotherapy, and review the literature. Despite the complete disappearance of the locally advanced tumor after the sequential chemoradiotherapy, recurrence and progression of tumor subsequently developed. The untoward event was believed to be due to the prolongation of the overall treatment time and the radiotherapy course. It is surmised that the continued use of sequential chemoradiotherapy in the management of head and neck cancer with carotid artery encasement can be justified, provided it is aggressive, timely, and without undue prolongations.

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Section: Discussionmentioning

confidence: 98%