Induction and Regulation of CD4
            <sup>+</sup>
            T Cell Subsets

Liew, F Y

doi:10.1002/9780470514672.ch11

Cited by 5 publications

(2 citation statements)

References 30 publications

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“…Further efforts are required to characterize the immunesuppressive mechanisms of Salmonella, an issue that will contribute to the understanding of pathogenesis as well as to improved vaccines. In addition, although many ethical questions will be associated with environmental spread of genetically modified organisms encoding human cytokines or chemokines, such approaches could also be beneficial to enhance and modulate the immune response, and should be considered to optimize Salmonella-based recombinant vaccines (Dunstan et al, 1996;Al-Ramadi et al, 2001;Liew, 1994;Whittle et al, 1997;Xu et al, 1997).…”

Section: Perspectivesmentioning

confidence: 98%

Rational design of Salmonella recombinant vaccines

Cheminay¹,

Hensel

2008

International Journal of Medical Microbiology

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Section: Perspectivesmentioning

confidence: 98%

Rational design of Salmonella recombinant vaccines

Cheminay¹,

Hensel

2008

International Journal of Medical Microbiology

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“…[1][2][3] CIH-induced lung inflammation is involved in the production of many inflammatory molecules, including tumor necrosis factor α (TNF-α) and interleukins (ILs), such as IL-1β, IL-6, and IL-2. 4 During inflammation, CD4 + T lymphocytes could differentiate into T helper 1 (Th1, pro-inflammatory) cells, which specifically release interferon gamma (IFNγ), 5 while regulatory T (Treg, anti-inflammatory) cells are suppressed, demonstrating reduction in CD4 + transforming growth factor-beta 1 + (TGF-β1) T cells. 6 Therefore, inhibition of lung inflammation is an effective path to prevent lung injury from CIH.…”

Section: Introductionmentioning

confidence: 99%

Long noncoding RNA HOXA-AS2 ameliorates chronic intermittent hypoxia-induced lung inflammation by regulating miR-17-5p/tipe2 axis

Gao

Zhang

et al. 2023

Allergol Immunopathol

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Purpose: The purpose is to confirm whether long noncoding RNA HOXA-AS2 relieves chronic intermittent hypoxia (CIH)-induced lung inflammation. Methods: Male Sprague Dawley rats were used to establisha CIH rat model. Hematoxylin and Eosin staining was used on the lung tissue injury to determine the successful construction of CIH animal model. Arterial partial pressure of oxygen (PaO2) and carbon dioxide (PaCO2) were measured. HOXA-AS2 was overexpressed to evaluate its role in the progression and development of CIH. T cell differentiation and cytokine production were determined using flow cytometry. Cell apoptosis was determined using terminal deoxynucleotidyl transferase dUTP nick end labelling assay kit. The target of HOXA-AS2 and miR-17-5p was predicted by the Encyclopedia of RNA Interactomes (ENCORI) and confirmed using luciferase assay. Results: HOXA-AS2 was downregulated in CIH rat models. Lung tissue injury was observed in CIH rats, and the injury was attenuated by the overexpression of HOXA-AS2. PaO2 was reduced and PaCO2 was induced in CIH rats, which was reversed by the overexpression of HOXA-AS2. The overexpression of HOXA-AS2 inhibited CIH-induced cell apoptosis. It also reversed alterations in the levels of interferon gamma (IFNγ), interleukin (IL)-2, IL-6, IL-1β, tumor necrosis factor alpha (TNF-α), and transforming growth factor beta1 (TGF-β1) in rats caused by CIH. The overexpression of HOXA-AS2 prevented the induction in CD4+ IFN-γ+ T cells and reduction in CD4+TGF-β1+ T cells. The overexpression of HOXA-AS2 upregulated tumor necrosis factor-alpha-induced protein 8-like 2 (tipe2) key regulator through directly targeting miR-17-5p. Further experiments proved that tipe2 was the direct target of miR-17-5p. Conclusion: This study manifested that HOXA-AS2 acted as an anti-inflammatory regulator and protected lung tissue injury from CIH in the rat model; this was mediated by upregulation of tipe2 through directly targeting miR-17-5p. HOXA-AS2 upregulated the expression of tipe2, providing new understanding and therapeutic target for CIH.

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Tumor-Associated Transforming Growth Factor-β and Interleukin-10 Contribute to a Systemic Th2 Immune Phenotype in Pancreatic Carcinoma Patients

Bellone

Turletti

Artusio

et al. 1999

The American Journal of Pathology

213

158

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In this study, we report coexpression of transforming growth factor-beta (TGF-beta) and interleukin-10 (IL-10) in pancreatic carcinoma tissue associated with significantly elevated levels of both cytokines in the sera of pancreatic carcinoma patients. Using conditioned media (CM) of pancreatic carcinoma cells, we further demonstrate that tumor cell-derived TGF-beta and IL-10 inhibited in an additive fashion both proliferation and the development of Th1-like responses in peripheral blood mononuclear cell (PBMC) preparations derived from normal donors. The antiproliferative and Th1-suppressive activities contained in CM of pancreatic carcinoma cells were due primarily to IL-10 and/or TGF-beta, as shown by the capacity of cytokine-specific neutralizing antibodies to reverse these effects. Finally, as compared to normal controls, PBMC derived from pancreatic carcinoma patients displayed a Th2-like cytokine expression pattern upon activation with either anti-CD3 antibody or Staphylococcus aureus strain Cowan I. Taken together, these results suggest that aberrant production of TGF-beta and IL-10 in pancreatic tumor patients skews T-cell cytokine production patterns in favor of a Th2 immunophenotype.

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Induction and Regulation of CD4 ⁺ T Cell Subsets

Cited by 5 publications

References 30 publications

Rational design of Salmonella recombinant vaccines

Rational design of Salmonella recombinant vaccines

Long noncoding RNA HOXA-AS2 ameliorates chronic intermittent hypoxia-induced lung inflammation by regulating miR-17-5p/tipe2 axis

Tumor-Associated Transforming Growth Factor-β and Interleukin-10 Contribute to a Systemic Th2 Immune Phenotype in Pancreatic Carcinoma Patients

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Induction and Regulation of CD4 + T Cell Subsets

Cited by 5 publications

References 30 publications

Rational design of Salmonella recombinant vaccines

Rational design of Salmonella recombinant vaccines

Long noncoding RNA HOXA-AS2 ameliorates chronic intermittent hypoxia-induced lung inflammation by regulating miR-17-5p/tipe2 axis

Tumor-Associated Transforming Growth Factor-β and Interleukin-10 Contribute to a Systemic Th2 Immune Phenotype in Pancreatic Carcinoma Patients

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Induction and Regulation of CD4 ⁺ T Cell Subsets