Induction and modulation of apoptosis in neonatal monocytes by polyunsaturated fatty acids

Impact of Polyunsaturated Fatty Acids on Oxidized Low Density Lipoprotein-Induced U937 Cell Apoptosis

“…Interestingly, in agreement with our results, EPA and ARA were also described as potent apoptosis inducers in human monocytes 36,37) . This raises the hypothesis of a specific effect of PUFA with 20 carbons, independently of the series involved (n-6 or n-3) and supports the role of inflammatory processes since these PUFA are both involved in prostaglandin and leukotriene pathways.…”

The modulatory effect of lipids and glucose on the neonatal immune response induced by Staphylococcus epidermidis

“…Addition of lipids at clinically meaningful concentrations had no significant effect, while 1% of lipids in whole blood cultures induced a pro-inflammatory response in both term and VLBW infants. This confirms previous studies that demonstrated an immunomodulatory effect of lipids on immune cells in adults [11-13, 19, 24], which explained the immunomodulatory effect by enhanced apoptosis of monocytes [24], inhibition of chemotaxis of neutrophils and increased bacterial clearance [25]. In previous studies we noted that the production of pro-inflammatory cytokines in response to S. epidermidis stimulation is dependent on gestational age, while counteracting anti-inflammatory cytokine production seemed individually regulated [20].…”

Effects of Dietary Polyunsaturated Fatty Acids on Mitochondria

“…Recent studies demonstrated that PUFAs affected proliferation and survival of various cell types in vitro and in different tissue in vivo [122][123][124][125][126]. Besides death receptormediated apoptosis the mitochondrial death pathway was also implicated in the effects of PUFAs on proliferation and survival.…”