2020
DOI: 10.3389/fnmol.2020.00061
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Inducing Partner Preference in Mice by Chemogenetic Stimulation of CA2 Hippocampal Subfield

Abstract: Social recognition is fundamental for social decision making and the establishment of long-lasting affiliative behaviors in behaviorally complex social groups. It is a critical step in establishing a selective preference for a social partner or group member. C57BL/6J lab mice do not form monogamous relationships, and typically do not show prolonged social preferences for familiar mice. The CA2 hippocampal subfield plays a crucial role in social memory and optogenetic stimulation of inputs to the dorsal CA2 fie… Show more

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Cited by 11 publications
(7 citation statements)
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“…The formation of selective social relationships is a particular hallmark of both human and prairie vole societies. Such relationships are difficult to study in traditional lab rodents because mice, rats, and other rodents typically do not form preferences for known peers or mates ( Triana-Del Rio et al, 2015 ; Schweinfurth et al, 2017 ; Beery et al, 2018 ; Cymerblit-Sabba et al, 2020 ; Insel et al, 2020 ; Beery and Shambaugh, 2021 ). In species that form specific relationships, selectivity may be based on reward and prosocial motivation toward specific individuals, or on avoidance (fear, aggression) of unfamiliar individuals.…”
Section: Introductionmentioning
confidence: 99%
“…The formation of selective social relationships is a particular hallmark of both human and prairie vole societies. Such relationships are difficult to study in traditional lab rodents because mice, rats, and other rodents typically do not form preferences for known peers or mates ( Triana-Del Rio et al, 2015 ; Schweinfurth et al, 2017 ; Beery et al, 2018 ; Cymerblit-Sabba et al, 2020 ; Insel et al, 2020 ; Beery and Shambaugh, 2021 ). In species that form specific relationships, selectivity may be based on reward and prosocial motivation toward specific individuals, or on avoidance (fear, aggression) of unfamiliar individuals.…”
Section: Introductionmentioning
confidence: 99%
“…Previously, we showed that loss of the Avpr1b from the pyramidal neurons of the CA2 results in inability of mice to recognize a familiar conspecific 67 . We also described an enhancement of social recognition following activation of the paraventricular nucleus (PVN) terminals in CA2, mediated by the Avpr1b 2 and, further, we were able to induce atypical partner preference behavior in mice through similar activation of the same neuronal pathway 8 .…”
Section: Introductionmentioning
confidence: 64%
“…Opposite-sex partner preference has also been assessed across a range of rodents of differing mating systems, including prairie voles, montane voles (Insel & Hulihan, 1995), meadow voles (Parker, Phillips, & Lee, 2001), California mice (Kowalczyk, Davila, & Trainor, 2018), mice (Cymerblit-Sabba et al, 2020), striped mice (Garnier & Schradin, 2019), and three gerbil species (Tchabovsky et al, 2019). Of these, partner preferences were most evident in prairie voles, meadow voles, female striped mice, and male Mongolian gerbils under control conditions.…”
Section: Subject Considerations: Other Speciesmentioning
confidence: 99%
“…Of these, partner preferences were most evident in prairie voles, meadow voles, female striped mice, and male Mongolian gerbils under control conditions. Other species, such as mice, showed partner preferences following specific neural manipulations (Cymerblit‐Sabba et al., 2020). Partner preference for a familiar mate has also been assessed with varied testing setups in other taxonomic groups including birds (zebra finches; Kingsbury & Goodson, 2014; Smiley, Vahaba, & Tomaszycki, 2012) and primates (marmosets; Carp et al., 2016).…”
Section: Commentarymentioning
confidence: 99%