Inducing cyclooxygenase-2 expression, prostaglandin E2 and prostaglandin F2α production of human dental pulp cells by activation of toll-like receptor-3, mitogen-activated protein kinase kinase/extracellular signal-regulated kinase and p38 signaling

Chang, Mei-Chi; Wu, Ju-Hui; Chen, Shyuan-Yow; Hsu, Yung-Ting; Yeung, Sin-Yuet; Pan, Yu-Hwa; Jeng, Jiiang-Huei

doi:10.1016/j.jds.2023.11.009

Cited by 1 publication

(2 citation statements)

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“…There are reports in the literature regarding the effect of LPS on the biological characteristics of MSCs. Several studies have explored the impact of bacterial LPS on the adhesion, migration, proliferation, and differentiation of dental stem cells [50][51][52][53].…”

Section: Effect Of Bacterial Lps On the Biological Characteristics Of...mentioning

confidence: 99%

“…Studies have shown that when dental pulp is damaged by bacteria, DPSCs can form reparative dentin as a protective barrier. Various approaches have been utilized to investigate the impact of different bacterial LPS on the adhesion, migration, proliferation, and differentiation of dental stem cells [50][51][52][53].…”

Section: Effect Of Bacterial Lps On the Biological Characteristics Of...mentioning

confidence: 99%

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Dental Stem Cells and Lipopolysaccharides: A Concise Review

Rodas-Junco,

Hernández-Solís,

Serralta-Interian

et al. 2024

IJMS

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Dental tissue stem cells (DTSCs) are well known for their multipotent capacity and regenerative potential. They also play an important role in the immune response of inflammatory processes derived from caries lesions, periodontitis, and gingivitis. These oral diseases are triggered by toxins known as lipopolysaccharides (LPS) produced by gram-negative bacteria. LPS present molecular patterns associated with pathogens and are recognized by Toll-like receptors (TLRs) in dental stem cells. In this review, we describe the effect of LPS on the biological behavior of DTSCs. We also focus on the molecular sensors, signaling pathways, and emerging players participating in the interaction of DTSCs with lipopolysaccharides. Although the scientific advances generated provide an understanding of the immunomodulatory potential of DTSCs, there are still new reflections to explore with regard to their clinical application in the treatment of oral inflammatory diseases.

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Section: Effect Of Bacterial Lps On the Biological Characteristics Of...mentioning

confidence: 99%