Inducible nitric oxide synthase expression on a rheumatoid nodule and in rheumatoid papules

Yamamoto,; Matsunaga,; Yokozeki,; Katayama,; Nishioka,

doi:10.1046/j.1365-2133.1998.02479.x

Cited by 5 publications

(3 citation statements)

References 10 publications

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“…In humans, NO productivity in patients with SSc was controversial: most authors reported an elevation [27][28][29][30][31][32] whereas others observed a reduction [33][34][35]. Those discrepancies could be explained by the heterogeneity and overlapping processes in patients.…”

Section: Discussionmentioning

confidence: 99%

Increased exhaled nitric oxide precedes lung fibrosis in two murine models of systemic sclerosis

et al. 2015

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Exhaled nitric oxide (NO) is increased as a result of lung inflammation, which in turn causes subsequent interstitial lung disease in patients with systemic sclerosis (SSc). However, the exact time course of inflammatory and fibrotic changes in the SSc lung has not yet been described. Our objective was to assess the chronological evolution of lung inflammatory and fibrotic processes in mice pre-treated with hypochlorous acid (HOCl) or bleomycin. C57BL/6 mice were randomized into three groups receiving subcutaneous injections of HOCl, bleomycin, or PBS for 2, 4 or 6 weeks. Exhaled NO (eNO) was measured at the end of each injection period and after 2 resting weeks without injection (8 week group). Mice were then sacrificed to obtain skin and lung tissues to measure fibrotic changes and NO synthases (NOS) expression. Increased eNO, inducible NOS and nitrotyrosine expression in bronchial epithelium, lung neutrophils and macrophages were observed at early phases in both HOCl- and bleomycin-treated mice. Conversely, lung vascular endothelial NOS expression decreased significantly at 6th and 8th weeks. Skin fibrosis was significantly increased from the 4th week and lung fibrosis from 6th week. We conclude that lung inflammation occurs early after injury as reflected by increased exhaled NO and inducible NOS expression, and precedes fibrotic changes in skin and lungs of mice pre-treated with bleomycin and HOCl. Early detection and treatment of pulmonary inflammation might be useful in preventing subsequent occurrence of lung fibrosis in SSc patients.

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Section: Discussionmentioning

confidence: 99%

Increased exhaled nitric oxide precedes lung fibrosis in two murine models of systemic sclerosis

et al. 2015

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“…This association is also reported to provide a barrier against the pathogenic attack. [26][27][28] Russula lepida was the highest distributed mushroom in all the regions of Odisha forests especially in the (Site-1,5,6) (76.92 %) followed by (Site-2,4) (Figure 5) (Figure 6). R. rosea was the second highest occurred mushroom (71.79%) in the varied forest divisions.…”

Section: Resultsmentioning

confidence: 96%

Tapping Unexplored Macrofungi: Occurrence and Distribution of Amanita, Russula and Termitomyces Species in the Different Forest Divisions of Odisha, India

Gupta¹

2015

APAR

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A systematic study was done on the wild mushroom species of the forest regions of Odisha with the objective to generate information on macrofungal diversity at different forest divisions of Odisha. Six major forest divisions of Odisha viz. Northern tropical semi evergreen forest (Site-1), Northern tropical dry deciduous forest (Site-2), Secondary moist miscellaneous semi evergreen forest (Site-3), Northern tropical semi evergreen forest (Site-4), Mixed forests having combination of Northern tropical semi evergreen forest and Tropical moist deciduous forest (Site-5), Tropical dry deciduous forest and Northern tropical semi evergreen forest (Site-6) were the sites for experiment emphasizing on Amanita, Russula and Termitomyces species. Nineteen different macrofungal populations were observed where 6 species of Amanita, 8 species of Russula and 5 species of Termitomyces were recorded from different habitats. Russula brevipes, Russula rosea and Russula lepida were very luxuriantly present in (Site-5). The distribution frequency was the highest (53.84%) in Amanita vaginata among all other species of Amanita. TheAmanita craseoderma and Amanita chrysoleuca were observed with the least distribution (2.56%). Termitomyces occurred in many places of Odisha and was considered as a palatable mushroom. Occurrence of T. eurrhizus was the highest (30.76%) in Odisha forests while Termitomyces microcarpus showed the least distribution (2.56%). The findings of the study have concluded that the (Site 1,5,6) can be a potential site for the mushroom hunters.

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“…NO, endogenously produced by lung tissue, has various physiological effects on both the ventilation and lung perfusion [3,4]. NO is a key mediator between endothelial cells, immune cells and fibroblasts [5]. Overproduction of NO, as a result of increased transcription of the gene encoding the inducible NOS, is seen in various lung disorders including acute lung injuries [6], pneumonia [7], cancer [8], sarcoidosis [9], pulmonary fibrosis [10] and asthma [11].…”

Section: Introductionmentioning

confidence: 99%

Measuring exhaled nitric oxide in animal models: methods and clinical implications

Le-Dong¹,

Duong‐Quy²,

Bei³

et al. 2012

J. Breath Res.

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Animal models such as rats and mice are useful for studying the multiple roles of nitric oxide (NO) in various respiratory disorders. The production of NO is catalyzed by the three isoforms of the enzymes (NO synthases; NOS). Indirect assessment of NOS gene or protein expression only provides partial information on the role of NO in health and lung disease. NO can also be measured in exhaled air by invasive or non-invasive approaches as a direct and quantitative marker of NO production in animal models. Whilst addressing the different methods of exhaled NO analysis in small animals (rats and mice), this review also focuses on the possible clinical implications, and discusses the advantages and limitations of these methods.

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Inducible nitric oxide synthase expression on a rheumatoid nodule and in rheumatoid papules

Cited by 5 publications

References 10 publications

Increased exhaled nitric oxide precedes lung fibrosis in two murine models of systemic sclerosis

Increased exhaled nitric oxide precedes lung fibrosis in two murine models of systemic sclerosis

Tapping Unexplored Macrofungi: Occurrence and Distribution of Amanita, Russula and Termitomyces Species in the Different Forest Divisions of Odisha, India

Measuring exhaled nitric oxide in animal models: methods and clinical implications

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