Inducible Genetic Lineage Tracing of Cortical Hem Derived Cajal-Retzius Cells Reveals Novel Properties

Gu, Xiaofeng; Liu, Bin; Wu, Xiaojing; Yan, Yan; Zhang, Ying; Wei, Yiquan; Pleasure, Samuel J.; Zhao, Chunjie

doi:10.1371/journal.pone.0028653

Cited by 35 publications

(57 citation statements)

References 30 publications

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“…2A-A3). Consistent with previous reports (Englund et al, 2005; Gu et al, 2011), we confirmed that Tbr2 protein was expressed in Cajal-Retzius cells in the cortical hem by examining coexpression of Tbr2 and the Cajal-Retzius cell markers p73 and Reelin. At E14.5, the majority of Tbr2+ cells in the cortical hem coexpressed p73 (Fig.…”

Section: Resultssupporting

confidence: 92%

Tbr2Expression in Cajal-Retzius Cells and Intermediate Neuronal Progenitors Is Required for Morphogenesis of the Dentate Gyrus

Hodge

Garcia²,

Elsen³

et al. 2013

J. Neurosci.

104

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The dentate gyrus (DG) is a unique cortical region whose protracted development spans the embryonic and early postnatal periods. DG development involves large-scale reorganization of progenitor cell populations, ultimately leading to the establishment of the subgranular zone (SGZ) neurogenic niche. In the developing DG, the T-box transcription factor Tbr2 is expressed in both Cajal-Retzius cells derived from the cortical hem that guide migration of progenitors and neurons to the DG, and intermediate neuronal progenitors (INPs) born in the dentate neuroepithelium that give rise to granule neurons. Here we show that in mice Tbr2 is required for proper migration of Cajal-Retzius cells to the DG, and, in the absence of Tbr2, formation of the hippocampal fissure is abnormal, leading to aberrant development of the transhilar radial glial scaffold and impaired migration of progenitors and neuroblasts to the developing DG. Furthermore, loss of Tbr2 results in decreased expression of Cxcr4 in migrating cells, leading to a premature burst of granule neurogenesis during early embryonic development accompanied by increased cell death in mutant animals. Formation of the transient subpial neurogenic zone was abnormal in Tbr2 conditional knockouts, and the stem cell population in the DG was depleted prior to proper establishment of the SGZ. These studies indicate that Tbr2 is explicitly required for morphogenesis of the DG, and participates in multiple aspects of the intricate developmental process of this structure.

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Section: Resultssupporting

confidence: 92%

Tbr2Expression in Cajal-Retzius Cells and Intermediate Neuronal Progenitors Is Required for Morphogenesis of the Dentate Gyrus

Hodge

Garcia²,

Elsen³

et al. 2013

J. Neurosci.

104

View full text Add to dashboard Cite

show abstract

“…transient axonal targets, in reminiscence of neocortical subplate neurons; Supe`r et al, 1998). Hippocampal CRc are also different from neocortical CRc in their development and their origins (Del Rio et al, 1996;Meyer et al, 1999;Meyer, 2010;Gu et al, 2011) reviews on hippocampal CRc are available (Frotscher, 1997;Fo¨rster et al, 2006a,b).…”

Section: Introductionmentioning

confidence: 99%

Cajal–Retzius cells: Update on structural and functional properties of these mystic neurons that bridged the 20th century

2014

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“…CR‐cells are among the earliest generated neurons (E9‐E11) in the brain, arising from various sources (Bielle et al, ; Cabrera‐Socorro, Hernandez‐Acosta, Gonzalez‐Gomez, & Meyer, ; Ceci, Lopez‐Mascaraque, & de Carlos, ; Grove, Tole, Limon, Yip, & Ragsdale, ; Gu et al, ; Hevner, Neogi, Englund, Daza, & Fink, ; Martinez‐Cerdeno & Noctor, ; Meyer, ; Meyer, Perez‐Garcia, Abraham, & Caput, ; Meyer & Wahle, ; Takiguchi‐Hayashi et al, ; Tissir et al, ). Hence, their integration into the hippocampal network underlies conditions, other than those for later‐born, radially migrating neurons (Bayer & Altman, , ; Caviness Jr., ; Soriano, Cobas, & Fairen, ; Super et al, ).…”

Section: Discussionmentioning

confidence: 99%

Integrity of Cajal–Retzius cells in the reeler‐mouse hippocampus

2018

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Cajal–Retzius (CR) cells are early‐born glutamatergic neurons that are primarily known as the early main source of the signal protein Reelin. In the reeler mutant, the absence of Reelin causes severe defects in the radial migration of neurons, resulting in abnormal cortical layering. To date, the exact morphological properties of CR‐cells independent of Reelin are unknown. With this in view, we studied the ontogenesis, density, and distribution of CR‐cells in reeler mice that were cross‐bred with a CXCR4‐EGFP reporter mouse line, thus enabling us to clearly identify CR‐cells positions in the disorganized hippocampus of the reeler mouse. As evidenced by morphological analysis, differences were found regarding CR‐cell distribution and density: generally, we found fewer CR‐cells in the developing and adult reeler hippocampus as compared to the hippocampus of wild‐type animals (WT); however, in reeler mice, CR‐cells were much more closely associated to the hippocampal fissure (HF), resulting in relatively higher local CR‐cell densities. This higher local cell density was accompanied by stronger immunoreactivity of the CXCR4 ligand, stroma‐derived factor‐1 (SDF‐1) that is known to regulate CR‐cell positioning. Importantly, confocal microscopy indicates an integration of CR‐cells into the developing and adult hippocampal network in reeler mice, raising evidence that network integration of CR‐cells might be independent of Reelin.

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Inducible Genetic Lineage Tracing of Cortical Hem Derived Cajal-Retzius Cells Reveals Novel Properties

Cited by 35 publications

References 30 publications

Tbr2Expression in Cajal-Retzius Cells and Intermediate Neuronal Progenitors Is Required for Morphogenesis of the Dentate Gyrus

Tbr2Expression in Cajal-Retzius Cells and Intermediate Neuronal Progenitors Is Required for Morphogenesis of the Dentate Gyrus

Cajal–Retzius cells: Update on structural and functional properties of these mystic neurons that bridged the 20th century

Integrity of Cajal–Retzius cells in the reeler‐mouse hippocampus

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