Inducible Costimulator (ICOS) and ICOS Ligand Signaling Has Pivotal Roles in Skin Wound Healing via Cytokine Production

Maeda, Satoshi; Fujimoto, Manabu; Matsushita, T.; Hamaguchi, Yasuhito; Takehara, Kazuhiko; Hasegawa, Minoru

doi:10.1016/j.ajpath.2011.07.048

Cited by 35 publications

(47 citation statements)

References 42 publications

(49 reference statements)

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“…Protein expression of IFN-γ showed a different pattern that was decreased after injury. This result was similar to the finding of Maeda et al (2011) in a mouse excisional wound study. IFN-γ is predominantly secreted by NK cells and T lymphocytes (Farrar and Schreiber, 1993).…”

Section: Cb 2 Receptor Activation Attenuates Inflammationsupporting

confidence: 94%

Pharmacological activation of cannabinoid 2 receptor attenuates inflammation, fibrogenesis, and promotes re-epithelialization during skin wound healing

Wang

Zhao

et al. 2016

European Journal of Pharmacology

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Section: Cb 2 Receptor Activation Attenuates Inflammationsupporting

confidence: 94%

Pharmacological activation of cannabinoid 2 receptor attenuates inflammation, fibrogenesis, and promotes re-epithelialization during skin wound healing

Wang

Zhao

et al. 2016

European Journal of Pharmacology

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“…In accordance with this possibility, the repair of excisional wounds was dramatically delayed in mice deficient in either ICOS or B7h; these mice showed decreased keratinocyte migration, angiogenesis, granulation tissue formation, and diminished infiltration of T cells, macrophages, and neutrophils (43). One possibility is that B7h + cells, which are recruited from the blood and the surrounding tissues for tissue defense and repair, are arrested in the injured tissue via B7h interacting with the ICOS that is expressed by the infiltrating T cells.…”

Section: Discussionmentioning

confidence: 68%

B7h Triggering Inhibits the Migration of Tumor Cell Lines

Dianzani

Minelli

Gigliotti

et al. 2014

The Journal of Immunology

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Vascular endothelial cells (ECs) and several cancer cells express B7h, which is the ligand of the ICOS T cell costimulatory molecule. We have previously shown that B7h triggering via a soluble form of ICOS (ICOS-Fc) inhibits the adhesion of polymorphonuclear and tumor cell lines to HUVECs; thus, we suggested that ICOS-Fc may act as an anti-inflammatory and antitumor agent. Because cancer cell migration and angiogenesis are crucial for metastasis dissemination, the aim of this work was to evaluate the effect of ICOS-Fc on the migration of cancer cells and ECs. ICOS-Fc specifically inhibited the migration of HUVECs, human dermal lymphatic ECs, and the HT29, HCT116, PC-3, HepG2, JR8, and M14 tumor cell lines expressing high levels of B7h, whereas it was ineffective in the RPMI7932, PCF-2, LM, and BHT-101 cell lines expressing low levels of B7h. Furthermore, ICOS-Fc downmodulated hepatocyte growth factor facilitated the epithelial-to-mesenchymal transition in HepG2 cells. Moreover, ICOS-Fc downmodulated the phosphorylation of focal adhesion kinase and the expression of β-Pix in both HUVECs and tumor cell lines. Finally, treatment with ICOS-Fc inhibited the development of lung metastases upon injection of NOD-SCID-IL2Rγnull mice with CF-PAC1 cells, as well as C57BL/6 mice with B16-F10 cells. Therefore, the B7h−ICOS interaction may modulate the spread of cancer metastases, which suggests the novel use of ICOS-Fc as an immunomodulatory drug. However, in the B16-F10–metastasized lungs, ICOS-Fc also increased IL-17A/RORc and decreased IL-10/Foxp3 expression, which indicates that it also exerts positive effects on the antitumor immune response.

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“…Total RNAs were extracted from muscle samples using QIAGEN RNeasy spin columns (QIAGEN, Crawley, UK) and real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR) was performed using the TaqMan® system (Applied Biosystems, Foster City, CA) on an ABI Prism 7000 Sequence Detector (Applied Biosystems) [20]. TaqMan probes and primers for IL-1β, IL-6, IL-10, IL-12α, IFN- γ, tumor necrosis factor (TNF)-α, monocyte chemoattractant protein (MCP)-1, and glyceraldehydes-3-phosphate dehydrogenase (GAPDH) were purchased from Applied Biosystems.…”

Section: Methodsmentioning

confidence: 99%

A Crucial Role of L‐Selectin in C Protein–Induced Experimental Polymyositis in Mice

Oishi

Hamaguchi

Matsushita

et al. 2014

Arthritis & Rheumatology

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Objective To investigate the role of adhesion molecules in C protein-induced myositis (CIM), a murine model for polymyositis (PM). Methods CIM was induced in wild type mice, L-selectin-deficient (L-selectin-/-) mice, ICAM-1-deficient (ICAM-1-/-) mice, and both L-selectin- and ICAM-1-deficient (L-selectin-/-ICAM-1-/-) mice. The severity of myositis, inflammatory cell infiltration, and mRNA expression in the inflamed muscles were examined. The effect of dendritic polyglycerol sulfate (dPGS), a synthetic inhibitor that suppresses the function of L-selectin and endothelial P-selectin, was also examined. Results L-selectin-/- mice and L-selectin-/-ICAM-1-/- mice developed significantly less severe myositis compared to wild type mice, while ICAM-1 deficiency did not inhibit the development of myositis. L-selectin-/- mice transferred with wild type T cells developed myositis. Wild type mice treated with dPGS significantly diminished the severity of myositis compared to control-treated wild type mice. Conclusions These data indicate that L-selectin plays a major role in the development of CIM, whereas ICAM-1 plays a lesser, if any, role in the development of CIM. L-selectin-targeted therapy may be a candidate for the treatment of PM.

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Inducible Costimulator (ICOS) and ICOS Ligand Signaling Has Pivotal Roles in Skin Wound Healing via Cytokine Production

Abstract: Skin wound healing is mediated by inflammatory cell in-

Cited by 35 publications

References 42 publications

Pharmacological activation of cannabinoid 2 receptor attenuates inflammation, fibrogenesis, and promotes re-epithelialization during skin wound healing

Pharmacological activation of cannabinoid 2 receptor attenuates inflammation, fibrogenesis, and promotes re-epithelialization during skin wound healing

B7h Triggering Inhibits the Migration of Tumor Cell Lines

A Crucial Role of L‐Selectin in C Protein–Induced Experimental Polymyositis in Mice

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