Inducible clindamycin resistance among clinical Staphylococcus aureus strains in Iran: A contemporaneous systematic review and meta-analysis

Memariani, Mojtaba; Memariani, Hamed; Moravvej, Hamideh

doi:10.1016/j.genrep.2021.101104

Cited by 3 publications

(2 citation statements)

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“…Various studies have reported a comparable proportion of inducible clindamycin resistance among S. aureus isolates obtained from human sources such as studies in Odisha state, eastern India, 22.0% [ 7 ]; Nepal, 23.4% [ 34 ]; Malaysia, 22.1% [ 35 ]; and Israel, 20.0% to 25.0% [ 36 ]. This finding is significantly higher than the findings of the iMLSB phenotype from the systematic review and meta-analysis in Iran with 10.4% overall prevalence [ 37 ]. In Indian studies, inducible clindamycin resistance rate was 5.2% in Kashmir valley [ 38 ], 7% in Assam [ 39 ], 15.2% in Chennai [ 40 ], 13.71% in the sub-Himalayan region [ 41 ], and 14.8% in central India [ 42 ].…”

Section: Discussioncontrasting

confidence: 56%

Inducible Clindamycin-Resistant Staphylococcus aureus Strains in Africa: A Systematic Review

Assefa

2022

International Journal of Microbiology

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Introduction. Excessive use of clindamycin enhances the acquisition of inducible clindamycin-resistant S. aureus strains, which is a significant health problem in Africa. The main objective of this review study was to determine the prevalence of inducible clindamycin resistance and related genes among S. aureus isolates in Africa. Methods. A qualitative systematic review was conducted on inducible clindamycin resistance among S. aureus isolates in Africa using electronic databases such as Google Scholar and PubMed. Articles published in English before 2021 were selected, and relevant data were extracted, collected, and analyzed. Results. In our search, 22 articles met the eligibility criteria for this review study. Of 3064 total S. aureus isolates, 605 had iMLSB phenotype. The overall prevalence of inducible clindamycin resistance in S. aureus isolates was 19.8% with a range of 2.9% to 44.0%. A high number of iMLSB phenotypes were observed in MRSA isolates (3.6–77.8%) than MSSA (0–58.8%). The overall prevalence of the iMLSB phenotype in MRSA strains was 26.8% (279/1041). The maximum peak prevalence of inducible clindamycin resistance among S. aureus isolates recorded in the continent was 44.0% in Egypt, followed by 35.8% in Libya and 33.3% in Uganda in 2017, 2007, and 2013, respectively. The highest prevalence of iMLSB phenotype in MRSA strains was reported in Egypt, 77.8%, followed by Nigeria, 75.0%, and Libya, 66.2%. Among the recovered drug-resistance genes, ermA, ermC, and msrA genes were commonly detected in Egypt with 67.9%, 70.0%, and 70.0% prevalence, respectively. Conclusion. This review highlights a higher inducible resistance of S. aureus, including MRSA strains to clindamycin in the continent. Regular screening of these strains, wise use of clindamycin, and molecular detection and genotyping of resistant genes are urgent.

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Section: Discussioncontrasting

confidence: 56%

Inducible Clindamycin-Resistant Staphylococcus aureus Strains in Africa: A Systematic Review

Assefa

2022

International Journal of Microbiology

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“…While all of these isolates were found to be resistant to penicillin, methicillin resistance was not detected in any of them. In a review which analyzed the data of the studies conducted on prevalence of MLS resistance in S. aureus strains isolated from humans in Iran, it was reported that the prevalence of iML resistance was 10% in S. aureus strains isolated from clinical samples taken from humans [46]. Çetin et al [47] reported that iML resistance was found in 15% of S. aureus isolates.…”

Section: Discussionmentioning

confidence: 99%

Phenotypic and Genotypic Characterization of Macrolide-Lincosamide-Streptogramin Resistance in Staphylococcus aureus Isolates from Bovine and Human

et al. 2023

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In this study, penicillin, oxacillin, and macrolide-lincosamide-streptogramin (MLS) resistance in S. aureus strains that were isolated from bovine mastitis cases, and human patients were investigated. Inducible clindamycin resistance (iML) was not found in 30 bovine isolates, while it was detected in 3 (10%) of 30 human isolates. MIC90 values of penicillin, oxacillin and macrolide-lincosamides (ML) were 2, 0.19, >256 µg/ml in bovine isolates and were 3, 3 and 0.19-1.5 µg/ml in human isolates, respectively. Streptogramin resistance was not found in both bovine and human isolates. Although the mecA gene was detected in all of the oxacillin resistant isolates, blaZ gene could not be detected in penicillin resistant isolates. The erm(B) gene was detected in 5 (38.6%) of 13 ML-resistant bovine isolates, and the mph(C) gene was detected in 2 (66.66%) of 3 human isolates. As a result, resistance to penicillin and oxacillin was found to be higher in human S. aureus isolates, while ML resistance was found to be higher in bovine isolates in this investigation. It was concluded that the presence of genes in extra-chromosomal elements associated to penicillin and macrolide resistance should be investigated. The data obtained from this study will contribute to the studies on antimicrobial susceptibility in the field of human and veterinary medicine.

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Staphylococcus aureus Isolated From Traditional Artisanal Raw Milk Cheese from Southern Brazil: Diversity, Virulence, and Antimicrobial Resistance Profile

Aguiar,

Ferreira,

Rubio Cieza

et al. 2024

Journal of Food Protection

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Inducible clindamycin resistance among clinical Staphylococcus aureus strains in Iran: A contemporaneous systematic review and meta-analysis

Cited by 3 publications

References 50 publications

Inducible Clindamycin-Resistant Staphylococcus aureus Strains in Africa: A Systematic Review

Inducible Clindamycin-Resistant Staphylococcus aureus Strains in Africa: A Systematic Review

Phenotypic and Genotypic Characterization of Macrolide-Lincosamide-Streptogramin Resistance in Staphylococcus aureus Isolates from Bovine and Human

Staphylococcus aureus Isolated From Traditional Artisanal Raw Milk Cheese from Southern Brazil: Diversity, Virulence, and Antimicrobial Resistance Profile

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