Induced urinary crystal formation as an analytical strategy for the prediction and monitoring of urolithiasis and other metabolism-related disorders

Laube, Norbert; Berg, W; Bernsmann, Falk; Gravius, Sascha; Klein, Florian; Latz, Stefan; Mallek, D. von; Porowski, Tadeusz; Randau, Thomas M.; Wasilewska, Anna; Fisang, C.

doi:10.1186/1878-5085-5-13

Cited by 9 publications

(12 citation statements)

References 72 publications

(54 reference statements)

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“…Calcium salt crystals are the primary composition material in pathological nephroliths and uroliths in humans 16 . Urinary calcium salt crystal formation requires that the calciuria (and oxaluria, for calcium oxalate crystals) be sufficient enough to overcome crystallization inhibitors in the urine and induce spontaneous heterogeneous nucleation 6,14,17,18 . While crystalluria can be benign, it can also lead to renal or urinary pathologies.…”

Section: Discussionmentioning

confidence: 99%

Calcium salt crystalluria in a captive chimpanzee (Pan troglodytes) population

Fendrich¹

2023

J of Medical Primatology

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Urinalysis is a standardized method of health monitoring in captive and wild chimpanzees (Pan troglodytes), as urine collection is noninvasive in nature and provides a significant amount of information about an individual's health. [1][2][3][4] Dipstick analysis and refractometry are feasible to perform in the field; however, it is more difficult to perform a urine sediment analysis outside of a hospital setting due to the equipment required and the time limitation on analyzing the sample. For this reason, sediment analysis is often not included in papers investigating primate urine samples.Microscopic crystalluria is identified during the urine sediment analysis portion of a urinalysis. While crystalluria can be benign or normal in herbivores, 5,6 it can also indicate kidney dysfunction, pH imbalance, or various toxicities. [5][6][7] Furthermore, crystalluria can cause disease due to renal mineralization, 6,7 or result in pathological nephrolithiasis or urolithiasis. 6 Renal disease is the second most common cause of morbidity and mortality in captive chimpanzees, 8,9 surpassed only by cardiac disease. 9 Renal disease has also been linked to various cardiac pathologies in humans 9 ; therefore, it is important to note the presence of crystalluria in chimpanzees so that further exploration of renal and cardiac function can be performed.This study explores calcium salt crystalluria in a captive chimpanzee population and analyzes the differences between samples with and without crystalluria. It also discusses the possible effects of diet and various medications on the occurrence of crystalluria.

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Section: Discussionmentioning

confidence: 99%

Calcium salt crystalluria in a captive chimpanzee (Pan troglodytes) population

Fendrich¹

2023

J of Medical Primatology

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“…Для описания патологического процесса, активность или интенсивность которого должны измерять предлагаемые маркеры, авторы публикаций использовали следующие термины: «активность камнеобразования» [7], «активность процесса камнеобразования» [8], «литогенная активность» (ЛА) [9], «литогенный процесс» [10,11], «интенсивность нефролитиаза» [12], «индивидуальный актуальный риск камнеобразования» [13], «индивидуальный литогенный потенциал» [14], «склонность к кристаллизации» [15], «общий кристаллизационный потенциал» [16]. Таким образом, не существует общепринятого термина для обозначения того, что мы в данном обзоре называем «активностью литогенного процесса» или «литогенной активностью».…”

Section: определение (дефиниция) маркера активности литогенного процессаunclassified

“…Доступный и удобный маркер ЛА, применяемый регулярно в домашних условиях, позволит добиться сдвига парадигмы от «лечения болезни» в виде дорогостоящего и рискованного удаления камней в сторону «заботы о здоровье» [13]…”

Section: заключениеunclassified

Markers of lithogenic activity in kidney stone disease

Alfimov

Shaderkina

Korolev

et al. 2023

Androl. genit. hir.

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Литогенный процесс развивается незаметно. Было предложено несколько маркеров для выявления активации литогенного процесса. В данном обзоре мы проанализировали опубликованные данные о принципах действия этих диагностических тестов и описали 6 групп маркеров литогенной активности: 1) концентрация в моче камнеобразующих и ингибирующих ионов, а также производные от них соотношения, индексы и степени перенасыщения камнеобразующими соединениями; 2) макромолекулы и другие молекулы-маркеры, определяемые в моче; 3) физические свойства мочи; 4) маркеры крови; 5) маркеры, определяемые инструментальными методами; 6) тесты индуцированной кристаллизации мочи. Самыми перспективными и наиболее успешными маркерами литогенной активности являются тесты индуцированной кристаллизации мочи, которые могут применяться для выявления периодов повышенной литогенной активности, что может дать возможность предотвратить камнеобразование за счет своевременного усиления терапии. Наличие доступного и удобного маркера литогенной активности, применяемого регулярно в системе дистанционного мониторинга, позволит реализовать персонализированную программу предотвращения рецидивов мочекаменной болезни.

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“…Early diagnosis of renal dysfunction is important for infants born in asphyxia as allows to correct fluid and electrolyte disturbances in time. Diagnosis of renal neonatal asphyxia is difficult because of the lack of specific clinical symptoms and lack of informativeness of traditional survey methods [5,6]. Relevance of the study determined the lack of highly sensitive and at the same time, the available non-invasive diagnostic methods for early detection of kidney damage in newborns.…”

Section: Introductionmentioning

confidence: 99%

Crystallographic Investigation of Urine in Newborn With Renal Disturbance Due to Asphyxia

et al. 2020

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The aim is to increase the efficiency of diagnosis of renal injury in neonates with asphyxia by identifying of structural markers according to research facies of urine in newborns of different gestational ages. Materials and methods: The study involved 150 full-term with signs of kidney damage due to asphyxia: 75 babies with severe asphyxia, and 75 children with moderateasphyxia and 100 preterm infants: 50 children with severe asphyxia and 50 children with moderate. Comparison groups: group 1 consisted of 20 full-term infants, group 2 which included 20 preterm neonates. Material for the study – morning portion of urine, which was collected at 8-10 a.m. on 1-2 and 7-8 days of life. Results: morphological picture of facies of newborns with asphyxia depends on the severity of pathological changes in the urine (proteinuria) and urine output. Structure of facies in babies with renal distorbance due to severe asphyxia indicates a significant loss of organic and mineral substances in the urine. The width of the peripheral zone facies, the amount of solid particles transferred depends on the severity of asphyxia, the difference in morphology facies is maintained even at the end of the early neonatal period. Conclusions: Analysis of dried drops of urine in infants with renal impairment on the background of asphyxia can be used as one of the criteria for assessing kidney function and have prognostic value.

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Induced urinary crystal formation as an analytical strategy for the prediction and monitoring of urolithiasis and other metabolism-related disorders

Cited by 9 publications

References 72 publications

Calcium salt crystalluria in a captive chimpanzee (Pan troglodytes) population

Calcium salt crystalluria in a captive chimpanzee (Pan troglodytes) population

Markers of lithogenic activity in kidney stone disease

Crystallographic Investigation of Urine in Newborn With Renal Disturbance Due to Asphyxia

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