Induced Synaptotagmin (SYT) Protein Family Binds to Membrane SNAP25 to Facilitate Vesicle Secretion in Murine Granulosa/Cumulus Cells during Ovulation

Anti‐Bacterial Factors Secreted From Cumulus Cells of Ovulated COCs Enhance Sperm Capacitation During In Vitro Fertilization

“…In turn, cumulus cells express specific genes that are distinct from those expressed in granulosa cells. 12,13 During ovulation, IL-6 and other cytokines are secreted and act by paracrine and autocrine mechanisms to induce COC expansion and the maturation oocytes exhibiting high developmental competence. 10 Interestingly, genes thought to be associated with immune cell function and innate immunity are expressed at high levels in cumulus cells prior to and after ovulation.…”

“…10,11 When COCs were cultured in vitro, the expression and secretion of selected cytokines and chemokines were induced by the EGF-like factors and mediated by a regulatory exocytosis system requiring SNAP25. 12,13 During ovulation, IL-6 and other cytokines are secreted and act by paracrine and autocrine mechanisms to induce COC expansion and the maturation oocytes exhibiting high developmental competence. 12,14 The secretion of chemokines by exocytosis was further increased during fertilization.…”