2020
DOI: 10.1007/s13167-020-00227-w
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Induced sputum metabolomic profiles and oxidative stress are associated with chronic obstructive pulmonary disease (COPD) severity: potential use for predictive, preventive, and personalized medicine

Abstract: Chronic obstructive pulmonary disease (COPD) is a highly heterogeneous disease, and metabolomics plays a hub role in predictive, preventive, and personalized medicine (PPPM) related to COPD. This study thus aimed to reveal the role of induced sputum metabolomics in predicting COPD severity. In this pilot study, a total of 20 COPD patients were included. The induced sputum metabolites were assayed using a liquid chromatography-mass spectrometry (LC-MS/MS) system. Five oxidative stress products (myeloperoxidase … Show more

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Cited by 32 publications
(25 citation statements)
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References 74 publications
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“…Similar approaches have already been applied to a comparable sample set in humans 15 , 16 ; namely, induced sputum. Induced sputum in humans provides a non-invasive method to sample airway biofluids that are enriched in proteins and may reveal novel mechanisms in the pathogenesis of respiratory diseases, such as asthma and chronic obstructive pulmonary disease 16 , 17 .…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Similar approaches have already been applied to a comparable sample set in humans 15 , 16 ; namely, induced sputum. Induced sputum in humans provides a non-invasive method to sample airway biofluids that are enriched in proteins and may reveal novel mechanisms in the pathogenesis of respiratory diseases, such as asthma and chronic obstructive pulmonary disease 16 , 17 .…”
Section: Introductionmentioning
confidence: 99%
“…Similar approaches have already been applied to a comparable sample set in humans 15 , 16 ; namely, induced sputum. Induced sputum in humans provides a non-invasive method to sample airway biofluids that are enriched in proteins and may reveal novel mechanisms in the pathogenesis of respiratory diseases, such as asthma and chronic obstructive pulmonary disease 16 , 17 . For equine derived samples, the proteomic approach is novel and follows a recent upsurge of interest in proteomic analysis of human airway secretions as a highly informative non-invasive method of assessing the mechanisms associated with lung disease 15 .…”
Section: Introductionmentioning
confidence: 99%
“…COPD is one of the leading causes of morbidity and mortality worldwide [24,27]. According to the Global Initiative for Chronic Obstructive Lung Disease (GOLD), the prevalence of COPD was 11.7% (95% CI 8.4% to 15.0%), indicating globally about 384 million people suffering from COPD [28].…”
Section: Discussionmentioning
confidence: 99%
“…This would be advantageous as equine tracheal secretions represent a rich source of: (i) cells, (ii) host-derived microbiome, (iii) transcriptome and (iv) local environment-derived proteins; and (v) are relatively simple to collect with minimal discomfort to the horse. Similar approaches have already been applied to a comparable sample set in humans 15,16 ; namely, induced sputum. Induced sputum in humans provides a non-invasive method to sample airway bio uids that are enriched in proteins and may reveal novel mechanisms in the pathogenesis of respiratory diseases, such as asthma and chronic obstructive pulmonary disease 16,17 .For equine derived samples, the proteomic approach is novel and follows a recent upsurge of interest in proteomic analysis of human airway secretions as a highly informative non-invasive method of assessing the mechanisms associated with lung disease 15 .…”
Section: Introductionmentioning
confidence: 99%
“…Similar approaches have already been applied to a comparable sample set in humans 15,16 ; namely, induced sputum. Induced sputum in humans provides a non-invasive method to sample airway bio uids that are enriched in proteins and may reveal novel mechanisms in the pathogenesis of respiratory diseases, such as asthma and chronic obstructive pulmonary disease 16,17 .For equine derived samples, the proteomic approach is novel and follows a recent upsurge of interest in proteomic analysis of human airway secretions as a highly informative non-invasive method of assessing the mechanisms associated with lung disease 15 . Application of both a transcriptomic and proteomic approach to equine TW samples has the potential to reveal novel biomarkers of early disease development or disease associated tissue remodelling.…”
Section: Introductionmentioning
confidence: 99%