Induced Production, Synthesis, and Immunomodulatory Action of Clostrisulfone, a Diarylsulfone from Clostridium acetobutylicum

Abstract

To ni Neuwirth, [a] Anne-Catrin Letzel, [a] Cedric Ta nk, [b] KeishiI shida, [a] Michael Cyrulies, [b] Lisa Schmçlz, [c] StefanL orkowski, [c] andC hristianH ertweck* [a, d]

Beyond Soil-Dwelling Actinobacteria: Fantastic Antibiotics and Where to Find Them

“…Thus, anaerobes only seem to produce specialized metabolites under the precise conditions in which they are required. Another interesting example of this is clostrisulfone (Figure 9), a diaryl sulfone from Clostridium acetobutylicum whose production is triggered by the addition of supraphysiological concentrations of cysteine to the fermentation medium [201]. Clostrubin A (Figure 9), isolated from the industrially relevant Clostridium beijerinckii, has been the first polyketide discovered from an anaerobe microorganism, and exhibits potent antibiotic activity against important nosocomial pathogens [202].…”

“…Thus, anaerobes only seem to produce specialized metabolites under the precise conditions in which they are required. Another interesting example of this is clostrisulfone ( Figure 9 ), a diaryl sulfone from Clostridium acetobutylicum whose production is triggered by the addition of supraphysiological concentrations of cysteine to the fermentation medium [ 201 ].…”