Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications
Jonas Cerneckis,
Hongxia Cai,
Yanhong Shi
Abstract:The induced pluripotent stem cell (iPSC) technology has transformed in vitro research and holds great promise to advance regenerative medicine. iPSCs have the capacity for an almost unlimited expansion, are amenable to genetic engineering, and can be differentiated into most somatic cell types. iPSCs have been widely applied to model human development and diseases, perform drug screening, and develop cell therapies. In this review, we outline key developments in the iPSC field and highlight the immense versati… Show more
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