Induced Pluripotent Stem Cells: Fundamentals and Applications of the Reprogramming Process and its Ramifications on Regenerative Medicine

Walia, Bhavita; Satija, Neeraj Kumar; Tripathi, Renu; Gangenahalli, Gurudutta

doi:10.1007/s12015-011-9279-x

Cited by 56 publications

(39 citation statements)

References 168 publications

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“…IPSCs are produced by in vitro reprogramming of somatic cells, often skin fibroblasts, to revert to an embryonic, pluripotent state . One goal of iPSC research is the potential to use these cells as in vitro models of diseases influenced by genetic risk factors, including PD.…”

Section: Additional Considerationsmentioning

confidence: 99%

Aging and Parkinson's disease: Different sides of the same coin?

2017

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Despite abundant epidemiological evidence in support of aging as the primary risk factor for PD, biological correlates of a connection have been elusive. In this article, we address the following question: does aging represent biology accurately characterized as pre-PD? We present evidence from our work on midbrain dopamine neurons of aging nonhuman primates that demonstrates that markers of known correlates of dopamine neuron degeneration in PD, including impaired proteasome/lysosome function, oxidative/nitrative damage, and inflammation, all increase with advancing age and are exaggerated in the ventral tier substantia nigra dopamine neurons most vulnerable to degeneration in PD. Our findings support the view that aging-related changes in the dopamine system approach the biological threshold for parkinsonism, actively producing a vulnerable pre-parkinsonian state.

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Section: Additional Considerationsmentioning

confidence: 99%

Aging and Parkinson's disease: Different sides of the same coin?

2017

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“…Theoretically, with the transplantation of specific cells created from autologus iPS cells, the cells that lacking can be replenished and replace by cells with the defects corrected, thereby relieving a patient`s symptoms. The mostly use somatic cells are fibroblasts, but different groups generated also iPS cells from other somatic cells providing evidence that is possible to reprogram cells of different origins (Deng, 2010;Ebben et al, 2011;Patel and Yang, 2010;Uemura et al, 2012;Vitale et al, 2011;Walia et al, 2012;Wong and Chiu, 2011;Zeng and Zhou, 2011). Other sources of iPSCs that can be easily reprogrammed are human keratinocytes (Aasent et al, 2008;Petit et al, 2012), oral mucosa fibroblasts (Miyoshi et al, 2010), dermal papilla cells (Tsai et al, 2010), pancreatic beta cells (Stadtfeld et al, 2008), neural stem cells (Kim et al, 2009), mature B lymphocytes (Hanna et al, 2008), liver and stomach cells (Aoi et al, 2008) and cord blood cells (Cai et al, 2010;Takenaka et al, 2009).…”

Section: Applications Of Human Ipscsmentioning

confidence: 99%

Induced Pluripotent Stem Cells and Their Implication for Biomedical Sciences

Csobonyeiová¹

2013

OnLine Journal of Biological Sciences

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The groundbreaking discovery, that somatic mammalian cells can be epigenetically reprogrammed to a pluripotent state through the exogenous expression of the transcription factors Oct4, Sox2, Klf4 and c-myc, has yielded a new cell type for potential application in regenerative medicine, the induced Pluripotent Stem Cells (iPSCs). Since the first demonstration of creating iPSCs in 2006 great efforts have been made into improving iPS cell generation methods and understanding the reprogramming mechanism as well as the nature of iPSCs. The iPSCs technique makes it possible to produce patient-specific pluripotent stem cells for transplantation therapy without immune rejection. However, some restriction still remain, including viral vector integration into the genome, the existence of exogenous oncogenic factors and low induction efficiency. In this review we discuss recent advances in methods of generating safer iPSCs lines and their possible use for biomedical applications.

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“…They can be designed to carry highly specific physicochemical features, making them an excellent option for targeted therapy. The aim of this review is to summarize the recent patents in the nanotechnology field that carry some clinical significance in the treatment of soft tissue, that eventually may change the way we approach some reconstructive procedures [22,23].…”

Section: Introductionmentioning

confidence: 99%

Promising recent regenerative medicine applications in plastic and reconstructive surgery

Eid¹,

Halen²

2015

Glob Surg

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Cosmetic and reconstructive surgery relies extensively on the complex relationship between skin, soft tissue and the underlying bone skeleton. Soft tissue loss and acquired soft tissue deficits are some of the daily challenges faced by the plastic surgeon. Fat grafting has become one of the standard lines of care that has various applications in plastic surgery treatments. The ability of adipose stem cells to rejuvenate by producing trophic factors, and to differentiate into different cell types, has provided promising utilization for a variety of different applications in plastic surgery. Bone disorders, including infection and poor healing, pose vexing problems to the reconstructive surgeon. Vascular surgery is a technique necessary for the reconstruction of the most challenging surgical defects, and has great potential for improvement through technology. Nanoscale refinements of current techniques may offer more efficient and improved surgical and non-surgical approaches for reconstruction. Such refinements will significantly expand our capabilities for innovative reconstructive interventions, with high efficiency, specificity and minimal invasiveness.

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Induced Pluripotent Stem Cells: Fundamentals and Applications of the Reprogramming Process and its Ramifications on Regenerative Medicine

Abstract: To conclude, we will briefly discuss the current problems that hinder bench to bedside translation of iPSC research as well as the possible steps that can bring iPSC therapy and other potential applications closer to fruition.

Cited by 56 publications

References 168 publications

Aging and Parkinson's disease: Different sides of the same coin?

Aging and Parkinson's disease: Different sides of the same coin?

Induced Pluripotent Stem Cells and Their Implication for Biomedical Sciences

Promising recent regenerative medicine applications in plastic and reconstructive surgery

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